FILTRODISC™ BIO SD is a filtration system which removes particles (e.g. cells, bacteria, yeast), impurities (e.g. HCP, DNA) and other turbid matter from process liquids (e.g. fermentation broths). This system is completely disposable; all material that comes in contact with the product is meant for single-use and can be disposed of after the filtration is completed. This “disposability” or “single-use” reduces cross contamination risks, cleaning validation efforts and downtime during filter changes, making this method the ideal choice for contract manufacturers (CMO) and other operations with a high frequency of product change. All sizes can be ordered gamma sterilized (upon request).
This is a highly advanced programmable pneumatic digital dispenser. It can store eight programmes and it can partially compensate for viscosity variation.
The dispenser features new digital controller technology with a clear digital display for a simultaneous overview of all parameters.
The Drifton 206-DF dispenser can store eight programmes in the controller’s memory and when it is programmed, it will adjust the pneumatic pressure automatically as the liquid becomes thicker or thinner.
The dispenser can partially compensate for variation in the dispensed medium.
Remember to order an air fitting to go with this one-component dispenser.
The new Bioreactor Cultivation Video Guide from INFORS HT illustrates the operational steps using the Minifors and Labfors bench-top bioreactors as examples.
E-Learning: Bioreactors Made Easy!
The video instructions allow students and newcomers to fermentation to run laboratory experiments on their own. These instructions were compiled in co-operation with the University of Applied Sciences, Esslingen, (Germany) and are now available from INFORS HT.
The Cultivation Video Guide takes the user through the bioprocess step-by-step through short video clips and numerous photographs and diagrams. The guide accompanies the user through the entire bioprocess from the preparation of the pre-culture and steps to get the bioreactor ready to the actual fermentation process.
The idea was conceived by Prof. Dr. Richard Biener, University of Applied Sciences, Esslingen (Germany), since bioreactors can be damaged easily if handled inappropriately. "The operation of a bioreactor requires comprehensive training," according to Dr. Biener. "The students are excited about the instructions since complex operating steps can be shown much more comprehensibly in a video sequence". The instructions make the students more confident in the operation of the bioreactor allowing them to work more on their own and independently in the laboratory.
Dr. Burkhard Feigel (Managing Director Infors GmbH), confirms: "Younger users especially get detailed instructions without any preliminary training which allows them to perform their tasks more easily and without external help. The advisers see the special benefit in the fact that students and pupils make fewer operating errors and there are fewer defects. Basically, the instructions are very well-tried and proven in educational settings and are a type of support that is welcomed by advanced users as well."
The Cultivation Video Guide for Minifors and Labfors bioreactors is now available from INFORS HT.
Product, performance and packaging: The New Eppendorf cell culture consumables deliver quality in all and offer a new dimension of safe, reproducible and reliable cell culture work.
Scientists and technical personnel in the field of cell culture have a strong need for easy, safe and reliable products with improved handling that help prevent contamination. The latest products from Eppendorf deliver exceptional levels of product purity and security, as well as improved, ergonomic and safe handling of cell cultures and advanced protection against contamination. The new, easy resealable packaging concept complements the products’ unique features and performance.
Eppendorf Cell Culture Consumables are made from ultraclear virgin polystyrene, which complies with USP class VI for highest purity. Cell Culture Consumables have a ISO class /GMP class C clean room production standard and a sterility assurance level (SAL) of 10-6 as well as batch specific 3rd party quality testing ensuring exceptional product and sample safety.
Innovative technologies in Eppendorf Cell Culture Consumables deliver ultimate ease of use. New high efficiency air filter technology in Eppendorf flasks provides improved contamination protection, while ConvexAccess™ neck geometry allows more ergonomic handling and facilitated entry into flasks. Meanwhile, a corrugated handling ring and new SplashProtect™ ring in dishes deliver safe, confident handling and better protection against contamination. Finally, Eppendorf’s new chimney well design in plates minimizes the “edge effect” and leads to more reproducible assay results.
Many cell culture applications require the constant use of a sterile safety cabinet, which often has a limited amount of space available. Eppendorf’s new packaging concept addresses this limitation through easy opening, truly resealable and shrinkable design, allowing safe storage and requiring less space, while an innovative tray allows easy removal of the products from the box and safe workflows.
From basic label design and printing to advanced import and editing options, LabelMark software improves the label-making experience for the electrical, industrial, aerospace, laboratory and telecom industries.
New LabelMark™ 6 software takes the hassle out of designing and printing labels. With an improved user interface and app-based navigation combined with Brady’s proven interactive label creation and single-click importing and serialization, you have high performance label printing that has never been easier.
Label Printing with an improved user interface:
Easy-to-use apps for creating wire harness, control panel and laboratory labels
Insert and edit AutoCAD layers, area of interests or entire files
Automatically repeat text on multiple lines of a label with LabelMark wire marker tool
Multi-label view for true representation of label formats
Adjust each individual label’s length in your print file
Quickly import data onto a label from an external data source
One-step serialization of data
“Check error” function to locate any import errors in prior to printing
Assign label materials to a specific printer for dedicated printing
Manage multiple files in a single job by grouping wire markers, push buttons, rating plates, and terminal block labels into one job file
Bi-directional communication with the IP, BMP®41, BMP®51,BMP®53, BMP®71 and BBP®33 printer series for automatic label format loading
The Development Microlute™ from Porvair Sciences is a Solid Phase Extraction (SPE) microplate which provides a wide assortment of phase chemistries and sorbent loadings in a single plate making it ideally suited for method development.
Offering scientists a choice of up to 12 different phases and sorbent loadings (10 -100mg) in a standard format 96-well plate the Development Microlute™ allows you to simply and rapidly screen for the optimal retention and selectivity required to achieve your sample preparation objectives. By providing a complete SPE methods development solution that does not need to be constructed by the user, the Development Microlute™ delivers considerable savings in valuable laboratory time.
The Development Microlute™ has been designed to provide all the advantages of automated and high throughput SPE sample preparation in a convenient microplate format capable of rapidly processing 96 samples in one go repeatedly and precisely. Constructed from a single piece of molded high quality polypropylene, a Development Microlute™ plate will not bend or distort because individual SPE cartridges do not have to be repeatedly plugged in and out. Using a proprietary sorbent slurry loading technique, Porvair has eliminated the channeling effects often limiting the performance of dry powder loaded SPE columns. Each well on a Development Microlute™ plate has an individual drain spout ensuring 100% sample transfer and zero crossover contamination.
Working closely with the leading automated liquid handling companies has ensured that Porvair Development Microlute™ plates deliver high productivity, trouble-free operation with all robotic sample handling and preparation systems.
The Octet platform includes instruments, biosensors, reagents and assay kits for analysis of biomolecular interactions in 96- and 384-well microplates.
Octet systems enable real-time, label-free analysis for determination of affinity, kinetics and concentration. Significantly easier, faster and better characterization of drug candidates is possible, providing greater value in drug development applications where existing methods have limitations in throughput, performance and cost.
Label-Free, Real-Time Results. Our proprietary Bio-Layer Interferometry (BLI) technology monitors the binding of proteins and other biomolecules to their partners directly in real time.
Higher Throughput. Octet systems perform sample analysis in 96- and 384-well microplates, processing up to 96 samples in parallel. Protein quantitation of 96 samples can be completed in as little as two minutes — a task that can take from 4 hours to overnight using traditional ELISA. Rapid kinetics, screening and epitope binning assays are enabled by the multiplexed biosensor formats.
High Quality Data at an Affordable Price. Octet systems provide definitive analysis of kinetic binding constants at a fraction of the price of traditional SPR systems.
Crude Sample Compatibility. Proteins can be assayed in crude mixtures such as cell lysates or hybridoma supernatants, glycerol, or in up to 10% DMSO, which drastically reduces sample preparation.
Today, embryonic stem cells (ESC) and induced pluripotent stem cells (iPS) represent the most significant types of pluripotent stem cells (PSC).
In the beginning, ESC were cultured on feeder cell layers, primarily murine embryonic fibroblasts (MEF), in non-defined culture media containing fetal calf serum (FCS). Later on, FCS would be replaced by somewhat more defined serum replacements and the introduction of extracellular matrix (ECM) coatings supporting self-renewal of ESC allowed for feeder-free culture using feeder-cell conditioned medium. However, the culture process remained time-consuming, laborious and poorly defined.
In recent years PSC-culture has experienced significant technical progress. Chemically defined media compositions became a standard, followed by the first xeno-free defined formulations. However, all these culture systems still depended on non-defined, xenogenic and poorly standardized ECM preparations – a contradiction in terms when using defined / xeno-free media. Importantly, research recently overcame this hurdle, identifying natural as well as synthetic ECM molecules and peptides that support undifferentiated PSC-expansion. Scientists are now capable of completely defined / humanized derivation and culture of hPSC.
Despite these recent technical advancements, the established hPSC culture systems still share unfavourable properties. Most of them use supra-physiologically high amounts of growth factors and / or contain substances purified from human or animal origin. In addition animal-derived and / or non-defined ECM is used. The PromoCell hPSC Growth Medium DXF consequently eliminates these disadvantages:
Chemically defined / xeno-free complete culture system
No human / animal derived components
Physiologically low in growth factors
This optimal culture environment allows for a well-controlled culture process, consistent and reproducible performance, robust support of pluripotency and improved cloning efficiency.
In combination with the extracellular matrix hPSC-ECM DXF and the hPSC Dissociation Buffer DXF, PromoCell provides a defined and xeno-free complete culture system for human pluripotent stem cells.
Cytation 3 is an automated digital microscope that provides high quality cellular imaging up to 60x in slides, microplates, Petri dishes and cell culture flasks.
Cytation™ 3 cell imaging multi-mode system combines automated digital microscopy and conventional multi-mode microplate detection in one instrument. This unique patent pending design provides rich phenotypic cellular information with well-based quantitative data, bringing cell biology research to a new level.
Fully integrated solution for automated fluorescence and brightfield microscopy of slides, microplates and flasksTemperature control to 45°C, CO2/O2 gas control and orbital shakingPowerful yet easy to use software for efficient image capture and analysisEliminates inconveniences commonly associated with conventional microscopy
The modular platform can easily upgrade to add conventional multi-mode microplate detection, to provide well-based intensity data along with phenotypic information from the microscope.
To fulfill its responsibility towards the consumer, BIOTECON Diagnostics decided to develop high-quality detection kits for food allergens.
To fulfill its responsibility towards the consumer, BIOTECON Diagnostics decided to develop high-quality detection kits for food allergens. Therewith, the well-known and respected spectrum offoodproof® real-time PCR kits is extended by another interesting product division.
The first allergen kits that will be launched by the company from Potsdam, Germany, are the foodproof® Celery Detection Kit and the foodproof® Gluten Detection Kit. More allergen kits for the detection of soy, peanut and hazelnut will follow soon. In combination with the foodproof® Sample Preparation Kit III for theextraction of plant DNA, this kits allows simple and safe detection of allergens in all kind of foods. Depending on the source of literature the prevalence of food allergies is between 2 – 4 % for adults and 4 -8% for children.
The foodproof® Sample Preparation Kit III allows the extraction of highly purified DNA even from complex foods or processed matrices. To validate the foodproof® Allergen Detection Kits final products, raw materials and swab samples have been successfully tested. The kit cannot be only used for foods, finished products and raw materials, but also for cleaning validations. In addition, BIOTECON Diagnostics has developed a standardized reference material, Allergen RM 800, to create a standard curve for exact quantification.
More allergen kits for the detection of mustard, sesame, lupine and crustacean will be developed next year. Also it is planned to develop multiplex kits, to detect up to three different allergen-parameters within one reaction.
Food allergens became more important, because the frequency in the population has grown in the last decades. The reasons are still not totally clear; often it is credited to changing environmental influences and diets. Even the smallest amounts of allergens can cause severe allergic reactions up to life-threatening symptoms. For the consumer, the only protection is avoidance. According to EU-regulation 2007/68/EG 14, different allergenic ingredients have to be labeled in Europe on the products. Until now there is no threshold value in Europe or elsewhere. Therefore, the zero tolerance rule applies, even foods that only contain traces of allergens have to be labeled accordingly.
Dr. Kornelia Berghof-Jäger, Chief Executive Officer (CEO) of the Germany-based corporation BIOTECON Diagnostics therefore announced that „the expansion of our product portfolio by test kits for the detection of food allergens is a consequent continuation of our strategy to cover all aspects of food safety diagnostics bymolecular methods.“
„The new product line allows the users of our foodproof® system to enter new markets with the existing laboratory equipment without any additional financial investments.” emphasizes Alois Schneiderbauer, Chief Business Officer (CBO) of BIOTECON Diagnostics stated.
Humanized NSG and NSG-SGM3 mice as a new preclinical bridge for immune-oncology therapies.
Humanized mice are a proven host for engraftment of human tumors or establishment of human immunity following hematopoietic stem cell transplantation. Understanding the interactions between human immune cells and tumors is paramount when devising treatment strategies that prevent tumor evasion of immune cells and improve cytotoxic responses.
FILTRODISC™ BIO SD is a filtration system which removes particles (e.g. cells, bacteria, yeast), impurities (e.g. HCP, DNA) and other turbid matter from process liquids (e.g. fermentation broths). more