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Nothing but Pure Pluripotency
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PromoCell

Nothing but Pure Pluripotency

In the beginning, ESC were cultured on feeder cell layers, primarily murine embryonic fibroblasts (MEF), in non-defined culture media containing fetal calf serum (FCS). Later on, FCS would be replaced by somewhat more defined serum replacements and the introduction of extracellular matrix (ECM) coatings supporting self-renewal of ESC allowed for feeder-free culture using feeder-cell conditioned medium. However, the culture process remained time-consuming, laborious and poorly defined.

In recent years PSC-culture has experienced significant technical progress. Chemically defined media compositions became a standard, followed by the first xeno-free defined formulations. However, all these culture systems still depended on non-defined, xenogenic and poorly standardized ECM preparations – a contradiction in terms when using defined / xeno-free media. Importantly, research recently overcame this hurdle, identifying natural as well as synthetic ECM molecules and peptides that support undifferentiated PSC-expansion. Scientists are now capable of completely defined / humanized derivation and culture of hPSC.

Despite these recent technical advancements, the established hPSC culture systems still share unfavourable properties. Most of them use supra-physiologically high amounts of growth factors and / or contain substances purified from human or animal origin. In addition animal-derived and / or non-defined ECM is used. The PromoCell hPSC Growth Medium DXF consequently eliminates these disadvantages:

  • Chemically defined / xeno-free complete culture system
  • No human / animal derived components
  • Physiologically low in growth factors

This optimal culture environment allows for a well-controlled culture process, consistent and reproducible performance, robust support of pluripotency and improved cloning efficiency.

In combination with the extracellular matrix hPSC-ECM DXF and the hPSC Dissociation Buffer DXF, PromoCell provides a defined and xeno-free complete culture system for human pluripotent stem cells.

Contact:

PromoCell GmbH

Sickingenstrasse 63/65

69126 Heidelberg

Germany

+49 6221 649 34 0

www.promokine.info

info@promokine.info

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Products

Life Technologies

This tool outlines the best products and services for your research needs, which can help save you weeks of hands-on time.

Life Technologies

From creating your gene to expressing your protein, Life Technologies offers a wide range of tools and expression systems that are easy to use, help enable rapid results, and offer high protein yields for every downstream application. This tool outlines the best products and services for your research needs, which can help save you weeks of hands-on time compared to using traditional methods. We even offer a complete service for the entire gene-to-protein workflow.

Request a copy of the Gene to Protein Brochure today by filling out the form here!

Or download the PDF version here!


Contactinformation for GeneArt® products and services:

Email: geneartsupport@lifetech.com

Europe: Tel: +49 (0)941 942 76100 Fax: +49 (0)941 942 76780

America and Asia: Tel: 800 955 6288 option 4/4/1

Advanced Analytical

The Oligo PRO™ 96XT system provides fast, automated and economical size-based purity analysis of single stranded DNA and RNA oligonucleotides, and double stranded RNA interference (RNAi) products.

Advanced Analytical

This dedicated analyzer is capable of analyzing 96 different samples simultaneously by parallel capillary gel electrophoresis with on-line, fixed wavelength UV absorbance detection. Preloaded and optimized separation and capillary conditioning methods simplify and streamline operation. The system can perform unattended analysis of up to 288 samples at once. Application-specific data analysis software provides automated or manual peak integration. The Oligo PRO™ is a proven technology used every day worldwide in production and research labs.


Key Features of the Oligo PRO™ System Include:

  • Low cost per sample.Unsurpassed throughput for oligo purity analysis!
  • Size-based, single nucleotide resolution from 10-mer to 80-mer lengths.
  • Easy to use and maintain with a low cost of ownership.
  • Minimal sample preparation and consumption.
  • DNA oligonucleotide and RNA oligonucleotide analysis.
  • New, native gel analysis for measuring purity and annealing efficiency of dsRNAi products.
  • A full line of available reagents for "turn-key" operation.


For further information please click here.

Eppendorf

The Reference 2 is the successor to the highly successful Reference pipette, and enhances the range’s already high standards with a new design, reduced weight and operating forces and multi-channel versions.

Eppendorf

As the premium product in Eppendorf’s pipette portfolio, the Reference 2 provides the most accurate results possible alongside robust, reliable handling and optimum user safety. These levels of security make the Reference 2 ideal for use with precious liquids, or in any application requiring extremely high levels of accuracy. When there can be no compromise on quality and reproducability, Eppendorf’s new Reference 2 is an ideal instrument for these liquid handling applications.

Applications:

  • Hide applications
  • Pipetting liquids
  • Volume determination
  • Mixing liquids
  • Filling of plates, gels, and reaction vessels
  • Phase extraction and removal of supernatants

Features:

  • The unique one-button operation offers a fast and ergonomic handling with reduced operating effort and active aerosol reduction. To avoid an accidential tip ejection a clear haptic feedback is provided.
  • The spring loaded tip cone improves user to user reproducibility and improved ergonomics by lowering tip attachment force
  • The Reference 2 multi channel offers a high flexibility incl a spring-loaded tip cone which can be switched on/off optionally
  • The secondary adjustment supports the easy adjustment of your Reference 2 for the most accurate pipetting of different liquids or other external conditions without the need for a full calibration.

For further information please click here.

Sartorius

BioPAT® SIMCA-online is a highly efficient software release for real-time multivariate statistical process monitoring and control of previously established Design Spaces.

Sartorius

Continuous real-time quality control and assurance is a highly desired state in biopharmaceutical manufacturing, which can be achieved by sophisticated process control strategies that use multivariate monitoring techniques to prevent or mitigate the risk of producing a poor quality product. Multivariate monitoring is based on models representing the relationship between parameters, whereas traditional process monitoring is based on univariate rules incapable of revealing correlation patterns and sometimes resulting in misleading conclusions.

BioPAT® SIMCA-online is a highly efficient software release for real-time multivariate statistical process monitoring and control of previously established Design Spaces based on current process parameters and (spectro) analytical data.

The software permits early detection of process deviations and provides user guidance for identifying potential root causes by displaying easy-to-understand graphics. This not only results in improved health, safety and environmental (HSE) performance, but also in enhanced control and assurance of the overall process and product quality.

Demo Versions you can find here!

Sartorius Stedim Biotech GmbH

August-Spindler-Strasse 11

37079 Göttingen, Germany

Phone: +49.551.308.0

Fax: +49.551.308.3289

info@sartorius-stedim.com

www.sartorius.de


Eppendorf

The electronic pipettes were specially designed for high professional standards to provide optimal support for you in your work.

Eppendorf

Simply better pipetting!


People who give 100 % every day deserve the best tool and the best equipment. You work on demanding problems, and important decisions depend on the results of your work. Your standard is extremely high and your performance is professional.

The electronic pipettes Eppendorf Xplorer and Eppendorf Xplorer plus were specially designed for high professional standards to provide optimal support for you in your work, with a new intuitive operating concept and design based on the proven Eppendorf PhysioCare Concept®.

These features set new standards for simplicity, precision andreproducibility, which means no more delays due to complicated programming or inflexible processes. Instead, you get precisely adjustable parameters, maximum reproducible results, fatigue-free work and consistent, full control over the pipetting processes.


For more information, please click here.

Tosoh Bioscience

The Immunoassay Analyser from Tosoh Bioscience offers the automation powers and performance of a large analyser in a bench top format.

Tosoh Bioscience

Random access allows any combination of tests, in any order at any time and a throughput of 36 results per hour with the first result in 20 minutes ensures a fast reliable service.


  • Will accept a variety of primary tubes with positive patient identification as well as positive test cup ID to eliminate errors.
  • Sample level sensing, to alert operator to short samples
  • Dual clot detection to maintain result integrity
  • Extremely simple operation
  • Unidirectional interface
  • Just 40 x 40 x 50cm and 30kg
  • Results are consistent and interchangeable between other Tosoh AIA analysers


The touchscreen, intuitive menus and onboard 'wizards' make the AIA-360 our easiest to use analyser to date.


Contact:

Tosoh Bioscience GmbH

Zettachring 6

70567 Stuttgart

Germany

Tel: +49-711-132570

Fax: +49-711-1325789

info.tbg@tosoh.com

www.tosohbioscience.com 

INFORS HT

With Iris 6 INFORS HT releases a new SCADA software package for parallel bioprocess control, which brings a fresh new look and a whole raft of new features.

INFORS HT

With Iris 6 INFORS HT releases a new SCADA software package forparallel bioprocess control. Iris 6 brings a fresh new look and a whole raft of new features to one of themost flexible and user friendly bioprocess control software programs available today. A special versionfor use with Multitron incubation shakers allows comprehensive process validation.

“Beginners will love the modern design and the easy navigation”, says Dr. Tony Allman, productmanager INFORS HT. A new ribbon menu provides quick access to the bioreactor and parametersettings. A variety of graphical displays such as correlation and bar graphs allow an easy interpretationof process data. The new version allows the user to annotate on-line graphics while a fermentation isin progress and to time-stamp samples for easy reference.

Advanced features such as the feedback control using sequences allow the experienced user toexplore all possibilities of bioprocess control. The seamless integration of both analysed and calculatedprocess parameters gives the users the possibility to achieve a combined record of all process data.“The implementation of off-line analysed parameters like OD or protein yield in the batch record file isgreat, now I can record all data in one single file”, says Dr. Michael Kaempf, Project Leader BioprocessDevelopment, EMPA (Switzerland). An enhanced reporter module makes creation of batch tickets, data export and printing both comprehensive and simple.

The Iris Parallel Bioprocess Control Software is available in 3 different packages depending on the type of equipment. The same software provides high quality data acquisition and sophisticated controlstrategies from shake flask up to pilot production.

All software packages can be qualified for validation purposes relating to FDA CFR Part 11, 21.


Contact:

Dr. Tony Allman, Product Manager Fermentation

Infors AG

Rittergasse 27

4103 Bottmingen

Switzerland

Phone: +41 (0)61 425 77 00

Fax: +41 (0)61 425 77 01

e-Mail: t.allman@infors-ht.com

Web: www.infors-ht.com

PromoCell

PromoKine’s plant-derived cytokines and growth factors are free of animal components, serum traces, and antibiotics.

PromoCell

Growing importance of fields like stem cell research require cytokines and growth factors produced in a safe host organism that prevent the occurrence of unwanted cellular responses caused by high endotoxin levels and other bacterial or mammalian impurities. Many commercially available cytokines and growth factors have endotoxin levels and other impurities high enough to seriously affect cellular processes like proliferation or differentiation.


PromoKine’s plant-derived cytokines and growth factors are free of animal components, serum traces, and antibiotics. They are also free of human, animal or bacterial infectious agents and have an endotoxin content typically 20-times lower than proteins produced in E. coli. Thus, they avoid problems caused by too high endotoxin levels and improve critical applications, e.g. in stem cell research.


Contact: 

PromoCell GmbH

Phone: +49 6221 649 34 0

www.promokine.info

info@promokine.info

Medicyte

The patented vericyte® technology allows an optimization of medium for primary cells based on the use of various combinations of specific proliferation factors.

Medicyte

Our patented vericyte® technology allows an optimization of medium for primary cells based on the use of various combinations of specific proliferation factors. At the moment we offer two unique vericyte® Growth Media: one for natural killer cells (NK cells) and one for endothelial cells (ECs).

vericyte® NK Cell Growth Medium

  • animal component free medium 
  • addition of vericyte® proliferation factors to basal medium resulted in an induction of NK cell proliferation with an expansion rate of over 50-fold
  • tested in ADCC (antibody-dependent cell-mediated cytotoxicity), Cytokine release assays and Natural Killing assays
  • cells can be cultured for 12 weeks

vericyte® EC Growth Medium 

  • enables up to 7 additional PDs compared to standard EC Growth Medium (up to 16 fold more cells)
  • EC cultured in vericyte® EC Growth Medium retain primary cell markers CD31 and van Willebrand factor and express those during expansion
  • 90% of the endothelial cells grown in vericyte® EC Medium are negative for senescence markers, regardless of the PD.
  • Also available as chemically defined medium

For more information about our vericyte® products visit: www.medicyte.com or send an email to sales@medicyte.com


Contact:

Medicyte GmbH

Im Neuenheimer Feld 581

69120 Heidelberg

Germany
 
sales@medicyte.com

www.medicyte.com

Medorex

"MedoClav" is a small media autoclave with 7 liter working volumes, an integrated stirring-system for the sterilization of different media under the pressure of 1 up to 3 bars.

Medorex

"MedoClav" is a small media autoclave with 7 liter working volumes, an integrated stirring-system for the sterilization of different media under the pressure of 1 up to 3 bars. medoClav has adjustable temperatures up to 143°C, integrated media sensor and a hold temperature of 60°C for the direct and sterile bottling of media. The stirrer of medoClav provides a homogeneous mixing of the liquids under predefined conditions and optimal strerilization. MedoClav can be supplemented with our tube pumps for semi-automated filling of sterile petri dishes and culture bottles and is best suitable for:

  • Sterilization of nutrient media
  • Sterilization of solid substances
  • Sterilization of liquids
  • Sterilization of media in oil bath

For further information please click here.

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