FILTRODISC™ BIO SD is a filtration system which removes particles (e.g. cells, bacteria, yeast), impurities (e.g. HCP, DNA) and other turbid matter from process liquids (e.g. fermentation broths). This system is completely disposable; all material that comes in contact with the product is meant for single-use and can be disposed of after the filtration is completed. This “disposability” or “single-use” reduces cross contamination risks, cleaning validation efforts and downtime during filter changes, making this method the ideal choice for contract manufacturers (CMO) and other operations with a high frequency of product change. All sizes can be ordered gamma sterilized (upon request).
The LabChip® GXII Touch System offers researchers an automated alternative to traditional methods by streamlining the multiple, manual steps of slab gel electrophoresis, while also providing the throughput and data quality essential in
the biotherapeutics workflow.
The platform supports multiple assays for characterizing proteins in reduced and non-reduced samples including: • Purity • Titre • Glycan screening • mAb charge heterogeneity • Fragmentation Analysis can be performed in as few as forty seconds per sample delivering comparable data to traditional capillary electrophoresis with as much as a 70X increase in throughput. Choose 96-well or up to 384-well platforms depending upon throughput needs. Using an easy to use touch screen interface, even occasional users get up and running samples quickly. TIBCO SpotFire® data visualization further enhances data output.
PerkinElmer offers solutions to ensure the consistent, reproducible results your biotherapeutics research and patient safety considerations demand. GLP-compliant processes in the world’s leading pharmaceutical, biotechnology and contract research organizations include our portfolio of assays and reagents, plate readers, liquid handling and technical expertise across the biotherapeutics workflow.
Sarstedt offers an extensive range of certified and geometrically optimised pipette tips with and without filters for all common pipettes.
The hydrophobic filter material prevents the aerosol, which is formed when pipetting, from contaminating the pipette. Our pipette tips are characterised by their high transparency and accuracy. Compliance according to DIN EN ISO 8655 is tested with the most common pipettes. The pipette tips are available in a bag, box or economical refill system, in three purity grades and as a low retention version.
Tailor-made solutions to suit virtually any drug discovery or advanced life science research application.
Empower your research with Tecan’s Spark® 20M multimode reader
Tecan has launched the Spark® 20M multimode microplate reader*, offering tailor-made solutions to suit virtually any drug discovery or advanced life science research application. This freely configurable system gives researchers access to new techniques and features intended to enhance and streamline biochemical and cell-based workflows. At the heart of the instrument are Spark’s unique Fusion Optics and a powerful, high frequency xenon flash lamp, which can be combined with your choice of high performance detection modules to ensure a perfect match for your workflow. Options include an enhanced fluorescence module designed to improve sensitivity and increase the speed of high throughput screening, and the newly developed Te-Cool™ cooling module that uniquely allows the measurement chamber temperature to be set below the ambient room temperature for more accurate and reliable results.
The Spark 20M’s cell handling capabilities have also been extended, with a new automated cell imaging and confluence measurement feature. This allows incubation and monitoring of cell culture microplates within the measurement chamber, enabling the user to define the confluence at which the assay starts/ends or the substrate is injected, for optimal assay results and greater walkaway operation. These new options – combined with the ability to read 6- to 1,536-well microplates – ensure there is a Spark 20M configuration to increase the productivity of your lab, both today and in the future.
Designed for efficient, small-scale purification and screening of histidine-tagged proteins from different sources.
His Mag Sepharose Ni products are magnetic beads designed for efficient, small-scale purification/screening of histidine-tagged proteins from different sources. Histidine-tagged proteins are captured using immobilized nickel ions followed by collection of the beads using a magnetic device. You can use magnetic beads to simplify sample handling during small-scale purification.
His Mag Sepharose Ni delivers:
High-capacity small-scale purification of histidine-tagged proteins from different sources
High purity and yield
Easy parallel screening of histidine-tagged proteins with high repeatability
Scalability—Simple capture of histidine-tagged proteins from small or large sample volumes (low microliter to milliliter scale)
The beads are available in three pack sizes: 2 × 1 ml 5% medium slurry, 5 × 1 ml 5% medium slurry, and 10 × 1 ml 5% medium slurry—a 1 ml 5% medium slurry is the same as 50 μl sedimented medium. A 1 ml medium slurry is sufficient for 5 purification runs according to the recommended protocol.
Together with MagRack 6, a separation tool for handling the beads in microcentrifuge tubes, up to six samples can be processed in parallel. You can easily screen a larger number of samples in parallel with high throughput on a robotic device.
The magnetic bead format has excellent properties for small-scale experiments. The high density of the beads allows rapid capture by magnetic devices while the visibility of the beads ensures reliable collection of the bound histidine-tagged proteins in the purification procedure. The characteristics of the media are summarized in Table 1. All the products are provided with protocols optimized for purification of histidine-tagged proteins.
Tabel 1. Characteristics of His Mag Sepharose Ni
Matrix: Highly crosslinked spherical agarose (Sepharose) including magnetite
Metal icon capacity: 21µmol Ni2+/ml medium
Binding capacity: approx. 50mg histidine-tagged protein/ml medium (approx. 500µg/purification run)
Particle size: 37 to 100µm
Working temperature: Room temperature and + 4ºC
Storage solution: 20% ethanol, 5% medium slurry
Storage temperature: Room temperature
GE Healthcare Europe GmbH
Dr. Michael Walther EMEA Marketing Manager Electrophoresis
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Flexible automation efficient titrations - Increase testing throughput in your lab with the single row InMotion Flex Autosampler.
Advanced Cleaning Sequences Ensure clean components and no carry over with the PowerShower™ rinse and dedicated conditioning beakers. Your sensors will be properly stored and ready for analysis with the automated Park function.
Efficient Operation Optimize efficiency in your laboratory using the LED status lights on the top of the InMotion towers. One quick look from across the lab lets you know if your autosampler is still running samples, is ready for more samples or needs your attention.
Compact and Modular The Flex is only 42 cm wide minimizing the bench space needed to automate your titrations. Add stacking magnetic pumps on the side of the InMotion Autosampler or the insert able option boards in the back of the autosampler. Expansion requires no more space.
Gel-free. Blot-free. Hands-free. A Simple Western is the Western you know well, only simplified.
Gel-free. Blot-free. Hands-free.
A Simple Western is the Western you know well, only simplified. It is not a workaround to the existing process, a Western-like substitute, or a partial solution. It's the real thing, completely reinvented. We at ProteinSimple think that's something to get excited about!
Get your time back. Load your samples in Simon, Sally or Peggy, press start and go enjoy your new hands-free time. Come back a few hours later to fully analyzed results. Get more consistency. People introduce variability—we arehuman after all. Simple Westerns are fully automated, so they just give you more reproducible data. Get truly quantitative. Since blot transfer of proteins isn't needed, you can get straight to real, quantitative results. Get more efficient. Sometimes you can only squeeze out enough sample for one experiment. Simple Westerns require a lot less protein and antibody so you have enough for those replicates.
• Learn about Simple Westerns • Learn about Peggy • Learn about Sally • Learn about Simon • Learn about NanoPro 1000 • Learn about Compass Software 21 CFR Part 11 Compliance • Simple Western Systems Comparison Chart
With 100g samples, the Peptone Starter Paks allow for you to identify the correct supplements for your specific cell line faster.
BD is helping you rethink supplementation. For more than 100 years, leading pharmaceutical companies have trusted BD peptones and supplements to help improve cell culture performance with higher cell titers and yield.
The new BD Peptone Starter Paks provide samples of our most widely used peptones tailored for specific applications, including monoclonal antibodies, recombinant proteins, and vaccines, for use in both mammalian cell culture and microbial fermentation.
With 100g samples conveniently packed in one box, you can identify the correct supplements for your specific cell line faster.
The BioShake series contains high-speed mixer and thermal mixer for small and very small volumes in microplates and reaction tubes and allows for the first time high precise and efficient mixing in the microliter scale for a wide range of applications.
Assays in microplates or reaction vessels can be realized fast and safe with using adjustable speed of 200 up to 3,000 rpm. The BioShake mixing-technology is obviously more robust, vibration free and needs less maintenance compared to classical mixers.
Programming the BioShake XP and BioShake iQ works via direct touch buttons. In addition two buttons for start and storage of time and mixing modes enable the instrument to run complex applications. This opens new points of view on the daily laboratory work and optimizes routine application enormously.
The short mix button allows short and fast mixing in between.
The two line LCD display guarantees simultaneous and safe reading of all programmed and measured parameters as time, mixing frequency and for BioShake iQ additional temperature.
The BioShake iQ is the high end thermal mixer of the BioShake series. In addition to the technical specifications of the model BioShake XP, the BioShake iQ comes with an very accurate heating technology. This allows highly reproducible results. The temperature range from RT to 99 °C is adjustable in 0.1 °C steps.
The temperature accuracy is ±0.1 °C, the temperature uniformity through all samples is better than ±1 °C.
The BioShake series is characterized by minor space requirement.
The BioShake series comes with a variety of standardized and specific adapter plates. The adapters allow an optimal fit for standard tubes, lysis tubes, microplates, glass vials and other sample vessels. An excellent temperature uniformity and homogeneity is guaranteed by using these adapters.
The GeneArt® CRISPR Nuclease mRNA is wild type Cas9 as mRNA, for genome editing using CRISPR-Cas9 technology.
High-efficiency CRISPR genome-editing tools for multiplex editing
The GeneArt® CRISPR Nuclease mRNA is wild type Cas9 as mRNA, for genome editing using CRISPR-Cas9 technology. Ready-to-transfect Cas9 mRNA circumvents the need for time-consuming cloning steps required when using CRISPR vector systems. Cas9 mRNA can be co-transfected with in vitro transcribed guide RNA (IVT gRNA) or a synthetic gRNA expression cassette containing U6 promoter. The gRNA expressing cassette and IVT gRNA template can be ordered as GeneArt® CRISPR Strings™ DNA, a 500 bp DNA fragment. Following transfection, the Cas9 protein is directed by gRNA to target specific genomic locus. This system allows multiplex genome editing, where multiple target gene sequences can be edited simultaneously in a single transfection reaction with the addition of multiple gRNAs. The system is versatile and simple to use, and changing target specificity only requires a change in the design of the GeneArt® CRISPR Strings™ DNA.
Humanized NSG and NSG-SGM3 mice as a new preclinical bridge for immune-oncology therapies.
Humanized mice are a proven host for engraftment of human tumors or establishment of human immunity following hematopoietic stem cell transplantation. Understanding the interactions between human immune cells and tumors is paramount when devising treatment strategies that prevent tumor evasion of immune cells and improve cytotoxic responses.
FILTRODISC™ BIO SD is a filtration system which removes particles (e.g. cells, bacteria, yeast), impurities (e.g. HCP, DNA) and other turbid matter from process liquids (e.g. fermentation broths). more