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MEDLINE SINGLE CHANNEL FIXED OR VARIABLE VOLUME MICROPIPETTES
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Medline

MEDLINE SINGLE CHANNEL FIXED OR VARIABLE VOLUME MICROPIPETTES

Laboratory equipment specialists MEDLINE SCIENTIFIC has introduced a range of micropipettes which are designed to provide optimal ease of use and assure a high level of user comfort during operation, minimising the risk of repetitive strain injury (RSI).

The Medline micropipette is manufactured in Germany, is CE-marked for IVD use and factory calibrated to dispense accurately under normal European ambient conditions (20° C, 50% humidity and 101Kpa barometric pressure).  Individual micropipettes are supplied with a calibration and test certificate and they are tested twice and calibrated to conform to EN ISO 8655 and DIN 12650 standards.

Integral to the design of the variable volume pipette is an innovative soft grip and safety device on the thumb-controlled plunger. This feature prevents accidental volume changes during use facilitating maximum precision and accuracy.  The universal two-step plunger allows reverse pipette techniques to be performed and enables last drop dispensing. This further contributes to a high level of accuracy in use.

Medline micropipettes may be safely autoclaved at 120°C and 1.05bar/15Psi for 15 minutes.  Maintenance and adjustment are simple procedures as the user can readily re-calibrate the micropipette with the adjustment tool supplied.  An operating manual is included with each instrument.

There are eight variable models covering volume ranges from 0.1 to 5000µl.  A further fourteen fixed volume models compliment the range covering 5 to 10,000µl and 4 or 6 position bench racks are available for easy storage.             


More details on these new pipettors are available from:

Lee or Emma at: 

Medline Scientific Ltd

Chalgrove

Oxfordshire, OX44 7XZ

UK.

Tel: +44(0) 1865 892 987

mail@medlinescientific.com

http://www.medlinescientific.com/en/New-Products/Pipettors/View-all-products.html

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Advanced Analytical Technologies

The Fragment Analyzer™ by Advanced Analytical is a fluorescence-based capillary electrophoresis instrument for both sizing and quantifying nucleic acids (DNA and RNA).

Advanced Analytical Technologies

By using a sensitive intercalating dye coupled with a powerful LED light source, Fragment Analyzer™ Automated CE System obviates the need for fluorescent labeled primers and can be used to separate dsDNA fragments and RNA (mRNA and total RNA). The Fragment Analyzer™ Automated CE System is the most flexible system on the market today, with the greatest sensitivity, the highest separation resolution over a wide range, the widest dynamic range and the fastest separation times.

This instrument comes available for customers who wish to run either 12 samples or 96 samples at a time.

Currently kits are available to:

• quantify and qualify NGS fragments.
• quantify and qualify RNA.
• quantify and qualify genomic DNA.
• do Mutation Detection, also known as TILLiNG, a reverse genetics technique.

The application kits help laboratories to streamline workflow and avoid bottlenecks typically found with competitive lab-on-a-chip methods. Gels formulated to provide high resolution separation are also available for general fragment analysis, such as SSR/microsatellites, small and large PCR fragments (amplicons) and resolve fragments sized between 10 bp and 40,000 bp with resolution down to 2bp.

Each and every kit is performance-tested prior to shipment to ensure quality, accuracy and ease of use for customers. Most kits require a single pipetting step before placement of the sample plate onto the instrument.

An analytical software package, PROSize™, greatly reduces post-separation analysis time. Put them all together — the instrument itself, the QC-tested application kits, and the analytical software — and the combination makes the Fragment Analyzer™ Automated CE System a powerful package for reducing labor and improving lab workflow and throughput.

Contact:

Advanced Analytical Technologies GmbH

Lutz Büchner

Im Neuenheimer Feld 583

69120 Heidelberg

Tel.: +49-(0)-6221-868058-20

lbuechner@aati-de.com

www.aati-de.com 

GE Healthcare

His Mag- and Ni Sepharose excel are immobilized metal ion affinity chromatography (IMAC) media (resins) designed for capture and purification of histidine-tagged proteins secreted into eukaryotic cell culture supernatants.

GE Healthcare

Nickel ions are very strongly bound to both media, enabling direct loading of large sample volumes without removing agents that normally would cause metal ion stripping. Both media significantly simplify and speed up the workflow and are excellent choices when working with purification of histidine-tagged proteins secreted from eukaryotic cells. 

Key features:

  • Load eukaryotic cell culture samples containing secreted histidine-tagged proteins directly with retained binding capacity
  • Increase target protein yield and decrease degradation through reduced and simplified sample handling
  • Choose between several different formats for screening and preparative purification of histidine-tagged proteins 

Background:

IMAC purification of histidine-tagged proteins secreted into eukaryotic cell culture supernatants has traditionally been challenging because of incompatibility between the IMAC medium and the cell culture medium. The cell culture medium strips the immobilized metal ions from the IMAC medium during sample loading, resulting in low or no binding of the target protein. The purification has been further complicated by the fact that the target protein concentration is often low. This requires the use of large sample volumes, which in turn might lead to increased metal ion stripping. Considerable sample pretreatment has been required to overcome these problems, an example being buffer exchange by diafiltration in combination with concentration procedures. Such pretreatment is time consuming, potentially harmful to sensitive proteins, and can cause unnecessary loss of target protein.


Contact Information:

GE Healthcare Europe GmbH

Life Sciences

Andrea Löhndorf, PhD, MBA

Regional Marketing Manager

Mobil: +49 (0)174 92 36 400

andrea.loehndorf@ge.com

www.gelifesciences.com

CETICS

AquaSpec mid-infrared spectroscopy creates digital metabolomic fingerprints of biological samples – in less than two minutes.

CETICS Healthcare Technologies GmbH

In contrast to conventional in-vitro diagnostic methods,  AquaSpec technology does not require sample preparation or consumables. It uses less than 100 microliters of sample volume and provides physicians with quantitative as well as qualitative information on important blood parameters – immediately and without time-consuming transport to diagnostic laboratories.

The core element of AquaSpec technology is the patented, ultrafine and high-precision flow cell especially developed for the measurement of aqueous biological samples. The flow cell is less than 10 µm thick, with a precision in the nanometer range, thus providing previously unrivalled measuring accuracy and reproducibility to exploit the full potential of modern mid-infrared spectroscopy. The high information content and digital archiving of the spectra open up completely new paths in analysis and diagnostics – also for retrospective studies, metabolomics studies, investigations, and the monitoring of disease and therapy processes.

Fields of application:

  • Toxicology
  • Cell Culture Quality Control
  • Pharmaceutical Development


Ask us for additional information:  

CETICS Healthcare Technologies GmbH

Schelztorstr. 54-56

73728 Esslingen am Neckar

Germany

Phone:+49 (0)711 300 655-0

Fax:+49 (0)711 300 655-29

e-mail: info@cetics-ht.com

BioTek

Cytation 3 is an automated digital microscope that provides high quality cellular imaging up to 60x in slides, microplates, Petri dishes and cell culture flasks.

BioTek

Cytation™ 3 cell imaging multi-mode system combines automated digital microscopy and conventional multi-mode microplate detection in one instrument. This unique patent pending design provides rich phenotypic cellular information with well-based quantitative data, bringing cell biology research to a new level.

Fully integrated solution for automated fluorescence and brightfield microscopy of slides, microplates and flasksTemperature control to 45°C, CO2/O2 gas control and orbital shakingPowerful yet easy to use software for efficient image capture and analysisEliminates inconveniences commonly associated with conventional microscopy

The modular platform can easily upgrade to add conventional multi-mode microplate detection, to provide well-based intensity data along with phenotypic information from the microscope.

DRIFTON

This is a highly advanced programmable pneumatic digital dispenser. It can store eight programmes and it can partially compensate for viscosity variation.

Drifton

The dispenser features new digital controller technology with a clear digital display for a simultaneous overview of all parameters.

The Drifton 206-DF dispenser can store eight programmes in the controller’s memory and when it is programmed, it will adjust the pneumatic pressure automatically as the liquid becomes thicker or thinner.

The dispenser can partially compensate for variation in the dispensed medium.

Remember to order an air fitting to go with this one-component dispenser.

Contact:

Drifton A/S
Avedøreholmen 84
DK-2650 Hvidovre
Tel.: +45 3679 0000
E-mail: info@drifton.dk 

Porvair Sciences Ltd

Porvair Sciences will present its complete range of automation friendly microplates and equipment at European Lab Automation 2012 in Hamburg, Germany in partnership with long-term collaborator, KBiosystems.

Porvair Sciences Ltd

Visitors to the Porvair / KBio stand at ELA 2012 will be able to see the Universal Robotic Manifold plus a growing range of high quality reagent reservoirs. The Universal Robotic Manifold is designed to be easily assembled and disassembled by robotic manipulators, thus enabling productive automation of SPE or DNA clean-up procedures. Able to accommodate collection plates from 14mm - 44mm in height and adaptable for working with short, medium and long skirts and drip directors, the Universal Robotic Manifold can operate with many different brands of filter plate and collection trays. Supplied with an integral vacuum gauge, the Manifold provides complete control of vacuum pressure ensuring plates can be processed with high reproducibility.

Combining uncompromising high quality with an affordable price - Porvair Sciences will display its extensive range of deep well, shallow well, storage, assay, SPE, protein precipitation and filtration microplates precisely manufactured to comply with ANSI/SBS dimensions ensuring complete compatibility with all automated sample handling systems, microplate readers and washers. 

Also on display will be the Ultravap RC - Porvair's all new robot-compatible nitrogen blow down station. For many years, Porvair Sciences has led the field in nitrogen blow down evaporation. This new version of Porvair's most popular sample concentrator makes it even easier to integrate an automatic dry down step into your automated liquid handling protocol.

Contact:

Porvair Sciences Ltd

Dorset House, Regent Park

Kingston Road, Leatherhead

Surrey KT22 7PL  UK

Tel: +44-1372-824290

Fax: +44-1372-824271

int.sales@porvair-sciences.com

www.porvair-sciences.com

GE Healthcare

rProtein A/Protein G GraviTrap includes ten ready-to-use columns prepacked with 1 ml of a mixture of 50% rProtein A Sepharose Fast Flow and 50% Protein G Sepharose 4 Fast Flow.

GE Healthcare

rProtein A/Protein G GraviTrap includes ten ready-to-use columns prepacked with 1 ml of a mixture of 50% rProtein A Sepharose Fast Flow and 50% Protein G Sepharose 4 Fast Flow.

•Prepacked gravity-flow columns provide convenience, save time, and increase the reliability of your results. 

•Purification of antibodies in 30 min allows you to quickly obtain and store your target protein in order to avoid the inherent dangers of protein instability and degradation associated with slow and long purification runs. 

•High purity and recovery with purity > 95% in one step and recovery typically 70% to 80%. 

•High binding capacity such as Protein A/Protein G GraviTrap ~ 35 mg human IgG/column. 

rProtein A/Protein G GraviTrap are prepacked gravity-flow columns designed for fast and efficient manual purification of monoclonal and polyclonal antibodies, antibody fragments from cell culture supernatant, and biological fluids. The antibodies are simply captured with high specificity on protein A and protein G ligands in gravity-flow columns. You do not need any other instrument with this protocol because the entire process relies on the flow of gravity. The yield varies from 20 to 50 mg of purified antibodies depending on the ligand you use. The columns are reusable up to five times.

Contact Information:

GE Healthcare Europe GmbH
Life Sciences
Andrea Löhndorf, PhD, MBA
Regional Marketing Manager
cell: +49 (0)174 92 36 400
andrea.loehndorf@ge.com
www.gelifesciences.com

Solentim

Solentim has announced the release of Cell Metric™ rapid, a high speed imaging and analysis system for cell line development.

Solentim

Solentim, the developer of tools for shortening the upstream cell line development workflow, has announced the release of Cell Metric™ rapid, a high speed imaging and analysis system for cell line development. The new product can be used to quickly and reliably screen hundreds of plates from limited dilutions via automated image capture and analysis. By offering unmatched speed, Cell Metric™ rapid is ideal for large-scale projects investigating the optimal conditions for cell growth, processing many thousands of clones per day with walk-away ease of use. It will be launched and displayed at the 2nd Annual Cell Culture and Bioprocessing Conference in London (4-5 November), while more details can also be found on the Solentim website.

Using Cell Metric™ rapid, images from an entire 96-well plate can be captured in just 45 seconds, offering a more than three-fold improvement over the standard Cell Metric™. Clear, high resolution images are captured right up to the well edge to generate accurate, comprehensive and reproducible results. This makes it ideal for a wide range of analyses including confluence determination, clone selection and colony growth formation. The Cell Metric™ rapid can also integrate with Solentim’s well-proven, temperature-controlled microplate stacker and loader. This space-saving system holds a batch of 10 plates and has been designed to increase throughput as part of a workflow that reduces user intervention, maximising the use of resources and time. To achieve the highest levels of automation, the Cell Metric™ rapid can integrate with a wide variety of third-party robot arms, to form a completely automated robotic work cell.

Cell Metric™ rapid joins a growing product portfolio that offers market-leading clone imaging with significantly better optics and automated detection capabilities than previous generation products.  Existing users have reported shaving up to three months off the development of a new cell line when using the Cell Metric™, while the accuracy provided by the system’s high resolution, whole-well imaging maximises the number of single cells that can be positively identified as clonal.

Aaron Figg, Managing Director of Solentim commented, “Automated analysis systems have the potential to significantly improve commercial cell line development at every stage of the process, from calibration of the cell dispensing methods and liquid handling steps, to the clone selection and right through to the optimisation of growth conditions and scale-up ready for manufacture. Our customers continue to report significant improvements in their process quality, time and cost savings from incorporating Cell Metric™ into their workflows.”

For further details about Cell Metric™ rapid, visit the Solentim website.


Contact details:

Commercial Enquiries:

Solentim Ltd.
Dr. Ian Taylor
Sales
Tel.: +44 (0) 7554 446 185

ian.taylor@solentim.com
www.solentim.com


Media Enquiries:

Chempetitive Group (UK office)

Dr Nicole Liska
Science Writer
Tel.: +44 (0) 1223 828 205

nliska@chempetitive.com
www.chempetitive.com

WYATT

Revolutionise your performance by transforming your conventional, batch dynamic light scattering system into the stable, automated DynaPro Plate Reader.

Wyatt Technology Europe GmbH

Automated, high-throughput, temperature-controlled Dynamic Light Scattering

Revolutionise your performance by transforming your conventional, batch dynamic light scattering system into the stable, automated DynaPro™ Plate Reader. The DynaPro Plate Reader incorporates state of the art technology, providing superior filter-free high throughput dynamic light scattering (DLS or QELS) performance. The non-invasive technology measures samples directly from industry-standard microplates (96, 384, or 1536 well plates) using as little as 4 microliters of sample per well. After the plate is loaded into the DynaPro, the data are collected automatically, in an unattended manner, by the easy-to-use DYNAMICS® software, which supports full integration with industry leading liquid handling robotics. Once the data are collected the samples can be recovered and the plates discarded – no cleaning required!

Save valuable time and increase your productivity by factor 10 or more!

All in all, the DynaPro DLS Plate Reader will help you increase your productivity by a factor of 10 or more when sizing biomolecules and other nanoparticles compared to conventional batch DLS systems. With the DynaPro Plate Reader, you can perform the classic DLS applications but with more confidence. Samples can be loaded in duplicate or triplicate, and scanned several times by the Plate Reader, providing you with data that are a true measure of sample repeatability and reproducibility. Due to the low sample volumes and automated capability, these experiments can be performed in less time and without the hassles of conventional batch DLS. Moreover, because the DynaPro Plate Reader can operate in an unattended fashion, there is no additional ‘cost’ – your valuable time – associated with exploring a much larger number of solution conditions or protein or other nanoparticle constructs. The DynaPro can perform accelerated stability, thermal melting, and temperature studies of multiple samples in parallel.

New: The DynaPro Plate Reader is now available with Extended Temperature Control and On-board Camera! The onboard camera in the DynaPro Plate Reader II can automatically acquire and store images of each well, giving scientists a new dimension of data acquisition, and instant insight into the behavior of their samples.

For further information please click here.

Contact information:

Wyatt Technology Europe GmbH

Hochstrasse 18

56307 Dernbach

Germany

Telephone: +49-(0)2689-925-0

E-Mail: info@wyatt.eu

Beckman Coulter Life Sciences

Beckman Coulter Life Sciences Introduces a 561 nm Laser Option for New Gallios Flow Cytometers at CYTO 2012 - Range of Detected Dyes and Fluorescent Proteins Expands

Beckman Coulter Life Sciences

A 561 nm laser option, available for new 561 nm-laser ready Gallios* flow cytometers from Beckman Coulter Life Sciences, will be on view at CYTO 2012, June 23-27 in booth 319 at the Congress Center in Leipzig, Germany. The 561 nm laser option provides researchers with the ability to analyze a greater range of fluorescent proteins and to more efficiently excite PE/PE tandems. Optimal excitation is offered for red fluorescent proteins such as mCherry and DsRed, which are being increasingly used in research labs.

Yellow-green excitation provided at 561 nm produces less autofluorescence in cells, increasing the signal-to-noise ratio for PE and DsRed detection.  Since 561 nm excitation is well separated from fluorescein and GFP emission, there is virtually no crossover contamination in the green detection channel, allowing simultaneous fluorescein, or GFP detection, without blocking optics.

The new laser is externally coupled through an optical fiber and can be field installed on new Gallios 561 nm-laser ready analyzers.  The 561 nm laser will be passed to the flow cell collinearly with the 488 nm laser during acquisition.

Available configurations for the Beckman Coulter Life Sciences’ Gallios flow cytometers are: 6 colour/2 laser, 8 colour/2 laser, 10 colour/3 laser and 10 colour/4 laser – the last configuration reflecting the 561 nm option. Six fluorescence detectors provide simultaneous acquisition of up to six fluorescence signals. Concurrent measurements of integral, peak and width are available for all parameters, including scatter and fluorescence signals.

“Expanding the colour options on the Gallios cytometer will extend the applications of the instrument for research scientists,” said Mario Koksch, director of project management and strategy at Beckman Coulter Life Sciences.  “Researchers will be able to further refine their studies using the full capabilities of the cytometer.”

Gallios cytometers feature an innovative forward-scatter detector that provides up to three measurements of cell size and visualization of particles down to 0.404 mm in diameter.  A side-scatter detector incorporates an independently focused, high-performance photodiode with electronic attenuation. A selection of up to 62 parameters can be processed per analysis, at acquisition rates of 25,000 events-per-second, with high yield.  Easily interchanged optical filters facilitate detection of a variety of dyes and wavelengths.


For more information: 

Beckman Coulter Life Sciences

Hillary Hunter, Public Relations

Tel: +1 714 961 5620

hillaryhunter@beckman.com

www.beckmancoulter.com

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