The ImagEM X2, a completely redesigned camera featuring a back-thinned EM-CCD sensor, offers maximum speed and precision performance for low-light imaging.
The ImagEM X2 makes superfast exposures possible and has the sensitivity to provide visually pleasing and quantitatively meaningful images in a photon-starved environment. It delivers 70 frames/s at the full resolution of 512 x 512 pixels with a high signal-to-noise ratio, enabling quantitative high-speed, low-light imaging. When binning or a region of interest is selected, this new camera produces images at even higher frame rates (up to 1076 frames/s).
Additional features allow for optimized camera triggering and streamlined connectivity through IEEE 1394b. The ImagEM X2 also has improved overall signal-to-noise ratio, increased non-EM dynamic range, and built-in EM gain measurement and calibration functions. It also features a software-controllable shutter that prevents EM gain degradation and image lag. To prevent EM gain degradation, the shutter is closed when the built-in EM gain protection feature is enabled. In addition, closing the shutter when a user replaces a lens, for example, can prevent image lag.
Cytation 3 is an automated digital microscope that provides high quality cellular imaging up to 60x in slides, microplates, Petri dishes and cell culture flasks.
Cytation™ 3 cell imaging multi-mode system combines automated digital microscopy and conventional multi-mode microplate detection in one instrument. This unique patent pending design provides rich phenotypic cellular information with well-based quantitative data, bringing cell biology research to a new level.
Fully integrated solution for automated fluorescence and brightfield microscopy of slides, microplates and flasksTemperature control to 45°C, CO2/O2 gas control and orbital shakingPowerful yet easy to use software for efficient image capture and analysisEliminates inconveniences commonly associated with conventional microscopy
The modular platform can easily upgrade to add conventional multi-mode microplate detection, to provide well-based intensity data along with phenotypic information from the microscope.
To fulfill its responsibility towards the consumer, BIOTECON Diagnostics decided to develop high-quality detection kits for food allergens.
To fulfill its responsibility towards the consumer, BIOTECON Diagnostics decided to develop high-quality detection kits for food allergens. Therewith, the well-known and respected spectrum offoodproof® real-time PCR kits is extended by another interesting product division.
The first allergen kits that will be launched by the company from Potsdam, Germany, are the foodproof® Celery Detection Kit and the foodproof® Gluten Detection Kit. More allergen kits for the detection of soy, peanut and hazelnut will follow soon. In combination with the foodproof® Sample Preparation Kit III for theextraction of plant DNA, this kits allows simple and safe detection of allergens in all kind of foods. Depending on the source of literature the prevalence of food allergies is between 2 – 4 % for adults and 4 -8% for children.
The foodproof® Sample Preparation Kit III allows the extraction of highly purified DNA even from complex foods or processed matrices. To validate the foodproof® Allergen Detection Kits final products, raw materials and swab samples have been successfully tested. The kit cannot be only used for foods, finished products and raw materials, but also for cleaning validations. In addition, BIOTECON Diagnostics has developed a standardized reference material, Allergen RM 800, to create a standard curve for exact quantification.
More allergen kits for the detection of mustard, sesame, lupine and crustacean will be developed next year. Also it is planned to develop multiplex kits, to detect up to three different allergen-parameters within one reaction.
Food allergens became more important, because the frequency in the population has grown in the last decades. The reasons are still not totally clear; often it is credited to changing environmental influences and diets. Even the smallest amounts of allergens can cause severe allergic reactions up to life-threatening symptoms. For the consumer, the only protection is avoidance. According to EU-regulation 2007/68/EG 14, different allergenic ingredients have to be labeled in Europe on the products. Until now there is no threshold value in Europe or elsewhere. Therefore, the zero tolerance rule applies, even foods that only contain traces of allergens have to be labeled accordingly.
Dr. Kornelia Berghof-Jäger, Chief Executive Officer (CEO) of the Germany-based corporation BIOTECON Diagnostics therefore announced that „the expansion of our product portfolio by test kits for the detection of food allergens is a consequent continuation of our strategy to cover all aspects of food safety diagnostics bymolecular methods.“
„The new product line allows the users of our foodproof® system to enter new markets with the existing laboratory equipment without any additional financial investments.” emphasizes Alois Schneiderbauer, Chief Business Officer (CBO) of BIOTECON Diagnostics stated.
Labfors with LabCIP, the world’s first self-cleaning, self-sterilising bench-top bioreactor, is revolutionising the biotechnology industry.
Now the LabCIP is available in a new design: the smaller housing can be stowed away to save space, yet retains its full functionality. It means that INFORS HT offers the modern researcher not only significant time savings, but also more space in the lab.
The Labfors with LabCIP bench-top bioreactor is revolutionising the biotechnology industry. As the world’s first self-cleaning, self-sterilising bench-top bioreactor, it not only saves users the tiresome job of cleaning and sterilising the bioreactor but also doubles the throughput rate. The LabCIP can perform its work overnight, making the Labfors ready to use again first thing the next day. This reduces the down time of the bioreactor to a minimum, allowing users to concentrate on their research.
And now the LabCIP is available in a new design: the reduction in overall height, allowing it to be stowed away to save more space, while retaining full functionality. It means that INFORS HT offers 21st Century capability in two key areas - saving time AND space.
Product, performance and packaging: The New Eppendorf cell culture consumables deliver quality in all and offer a new dimension of safe, reproducible and reliable cell culture work.
Scientists and technical personnel in the field of cell culture have a strong need for easy, safe and reliable products with improved handling that help prevent contamination. The latest products from Eppendorf deliver exceptional levels of product purity and security, as well as improved, ergonomic and safe handling of cell cultures and advanced protection against contamination. The new, easy resealable packaging concept complements the products’ unique features and performance.
Eppendorf Cell Culture Consumables are made from ultraclear virgin polystyrene, which complies with USP class VI for highest purity. Cell Culture Consumables have a ISO class /GMP class C clean room production standard and a sterility assurance level (SAL) of 10-6 as well as batch specific 3rd party quality testing ensuring exceptional product and sample safety.
Innovative technologies in Eppendorf Cell Culture Consumables deliver ultimate ease of use. New high efficiency air filter technology in Eppendorf flasks provides improved contamination protection, while ConvexAccess™ neck geometry allows more ergonomic handling and facilitated entry into flasks. Meanwhile, a corrugated handling ring and new SplashProtect™ ring in dishes deliver safe, confident handling and better protection against contamination. Finally, Eppendorf’s new chimney well design in plates minimizes the “edge effect” and leads to more reproducible assay results.
Many cell culture applications require the constant use of a sterile safety cabinet, which often has a limited amount of space available. Eppendorf’s new packaging concept addresses this limitation through easy opening, truly resealable and shrinkable design, allowing safe storage and requiring less space, while an innovative tray allows easy removal of the products from the box and safe workflows.
For convenient and secure sterile connection of flexible tubing in large volume operations.
Kleenpak II sterile connectors allow for the dry connection of two separate fluid pathways, while maintaining the sterile integrity of both, even in an uncontrolled environment. The connector consists of a male and a female connector, each covered by an aluminum peel-away strip that protects the port and maintains the sterility of the sterile fluid pathway prior to connection.
The Kleenpak II sterile connector has been designed to allow for the connection of large processing equipment in order to obtain fast, safe and reliable sterile transfer of large volumes.With this sterile connector, large single-use systems ( > 100 L), such as the AllegroTM systems, will be operated at much faster speeds. There will be minimal fluid restriction in thetubing lines.
Different connector options are available to allow for the connection of 19 mm (3⁄4 in.) and 25.4 mm (1 in.) ID nominal tubing including a 25.4 - 38.1 mm (1 - 11⁄2 in.) sanitary flange compatible fitting for maximum operational flexibility. Kleenpak II sterile connectors can be either gamma irradiated to a maximum of 50 kGy or autoclaved up to 130°C to suit different processing requirements.
The µDAWN™ Multi-Angle static Light Scattering (MALS) detector performs absolute characterization of macromolecules eluting from UHPLC, determining molar mass and size independently of retention time and molecular reference standards.
The µDAWN™ Multi-Angle static Light Scattering (MALS) detector performs absolute characterization of macromolecules eluting from UHPLC, determining molar mass and size independently of retention time and molecular reference standards. This instrument offers superb sensitivity over a wide range of molar mass, size and concentrations. In most respects the µDAWN is similar to the well-established miniDAWN™ TREOS™, a workhorse MALS instrument used in hundreds of labs around the world for characterizing proteins and other molecules smaller than 50 nm in radius.
Distinctly from the miniDAWN, the µDAWN is uniquely suitable for use in conjunction with UHPLC Size Exclusion Chromatography (µSEC-MALS) thanks to its small interdetector dispersion. In some cases it may be used with ion-exchange or other types of chromatography. Regardless of the specifics, the µDAWN produces minimal band broadening in order to maintain the narrow peaks typical of UHPLC.
The µDAWN may also be used in microbatch (off-line) mode or in conjunction with a Calypso IICG-MALS system for characterization of macromolecular interactions: affinity and absolute stoichiometry, label-free and immobilization-free, as well as second virial coefficients, cross virial coefficients, average molar masses and sizes.
GE Healthcare launches Cytell™ Cell Imaging System for compact, app-driven, automated imaging - Streamlines data acquisition, analysis and visualisation
Cytell™ Cell Imaging System is an intuitive benchtop instrument equipped with on-board data analysis and visualisation tools. It streamlines and simplifies routine assays such as cell cycle and cell viability and efficiently delivers high quality, quantitative results.
Key to the simplification are the on-board Bioapps; pre-configured, easy to use software modules that automate all the steps from imaging and data acquisition through data analysis, visualisation and report generation. The Cytell cell imaging system is compact and small enough to sit on a benchtop.
Cytell can image a wide variety of sample formats including slides, petri dishes, T-flasks and microplates. Compatible GE Healthcare Life Sciences reagents and kits are available, although Cytell is an open system and therefore provides the flexibility to create customized protocols based on other suppliers’ reagents.
BioApps currently available include:
Digital Imaging BioApp: Acquire fluorescence and transmitted light images of samples in plates, flasks, Petri dishes, or slides.
Automated Imaging BioApp: Automatically acquire high-quality fluorescence and transmitted light images from an entire multiwell plate in minutes.
Quick Count BioApp: Obtain accurate cell counts and viability and concentration estimations based on fluorescence intensity using a disposable hemocytometer.
Cell Cycle BioApp: Analyze cell cycle phase distribution in multi-well format using a DNA-binding fluorophore.
Cell Viability BioApp: Run two- or three-color assays in multiwell formats with subpopulation gating to determine the percentages of live, dead, and non-viable cells.
With improvements to the product and above all with enhanced documentation, the new minilab presents a huge number of new research opportunities for any user.
A new edition of the "lab in a suitcase"
For many years the Zinsser minilab has been an important component as a teaching aid in chemistry lessons in schools and universities. Now, with improvements to the product and above all with enhanced documentation, the new minilab presents a huge number of new research opportunities for any user.
Even though in the modern fine chemical industry and in pharmaceutical research and development where the smallest possible sample and reagent volumes are used (from a few mls and µls), for practical teaching, the experimentation often takes place in the front of the whole lesson with the use of larger volumes - up to 100mls - in schools and universities.
Containing an innovative set of glass equipment, the Mini Lab „lab in a suitcase“ is now used in many schools in different countries. There is now a new manual available for Mini Lab which includes more than 40 experiments - from basic operations such as distillation, filtration etc to complex syntheses such as colorants as designed by Prof. Michael Schallies. The instructions for the equipment configuration are easy to understand and are explained by simple drawings. General tips for the implementation of single experiments, material notes as well as danger symbols for the reagents are also included in the test description. The expected experimental results are also described in detail and partly documented with pictures or graphics. In the appendix of the manual there are detailed explanations of the potential dangers and also safety tips.
Current Owners of the Mini Lab can have a new updated manual for a small nominal charge.
Zinsser Analytic GmbH develops and manufactures in Germany and supplies customized automation technology and laboratory accessories for the global market. The company has specialized in the supply of high end technological products and systems for automated analysis in the fine chemical industry and also biological research and development. The company has grown over the years reaching a turnover in the range of double-digit millions and has about 60 employees to date.
Sartorius Stedim Biotech, a leading global supplier of the biopharmaceutical industry, is introducing a brand-new, scalable range of single-use bags.
Its completely new developed product family Flexsafe enables theimplementation of single-use bioprocessing throughout all steps of drug manufacture, fromprocess development to production, in upstream and downstream – all using just the oneinnovative polyethylene film. The innovative concept of the Flexsafe family addresses key industryrequirements for future-proof single-use manufacturing of commercial vaccines and drugs.
Flexsafe is based on a multilayer, proprietary polyethylene (PE) film, called S80, and has beendeveloped in close collaboration with resin and film suppliers. A standardized cell growthassay has been used to optimize film formulation, determine the operating ranges for extrusion,welding and gamma-irradiation processes and to establish specifications and process controls.
Flexsafe ensures excellent and reproducible cell growth behavior of the most sensitive celllines. The optimization of the resin formulation, the complete control of raw materials, theextrusion process and the bag assembly guarantee lot-to-lot consistent cell growthperformance. With its robust 400 μm thick PE film, Flexsafe is the strongest and most flexiblebag currently on the market. The bags enable safe and easy-to-use operation, even in themost demanding applications such as liquid shipping and large-scale stirred bioreactors.
Furthermore, batch-to-batch consistent extractables and leachables profiles support drugmanufacturers throughout the entire lifecycle of modern biological treatments from clinicaldevelopment to commercial supply many years after launch. Users can gain assurance thattheir initial extractable and leachable qualification work and data remain valid every timethey operate their single-use Flexsafe bioprocess.
Assurance of supply, one of the most important aspects for manufacturers, is guaranteed as aresult of long-term contracts with suppliers and business continuity plans with defined safetystocks and global manufacturing capabilities including resin manufacturing.
„Flexsafe represents a completely new generation of single-use bags. They offer our customersconsistent cell growth as well as extraordinary robustness and flexibility. In addition asustainable supply chain and consistent film throughout the entire manufacturing process isguaranteed. Every single one of these benefits sets a new benchmark. Being unique in all ofthem makes us very proud”, stated Stefan Schlack, Senior Vice President Marketing andProduct Management at Sartorius Stedim Biotech.
Sartorius Stedim Biotech is launching Flexsafe RM bags (1L-200L) and small bags for validationpurposes first. Bags for single use bioreactors BIOSTAT STR (50-2000L) and additional applications such as storage, mixing, shipping freeze and thaw will be rolled out step by step.
AquaSpec mid-infrared spectroscopy creates digital metabolomic fingerprints of biological samples – in less than two minutes.
In contrast to conventional in-vitro diagnostic methods, AquaSpec technology does not require sample preparation or consumables. It uses less than 100 microliters of sample volume and provides physicians with quantitative as well as qualitative information on important blood parameters – immediately and without time-consuming transport to diagnostic laboratories.
The core element of AquaSpec technology is the patented, ultrafine and high-precision flow cell especially developed for the measurement of aqueous biological samples. The flow cell is less than 10 µm thick, with a precision in the nanometer range, thus providing previously unrivalled measuring accuracy and reproducibility to exploit the full potential of modern mid-infrared spectroscopy. The high information content and digital archiving of the spectra open up completely new paths in analysis and diagnostics – also for retrospective studies, metabolomics studies, investigations, and the monitoring of disease and therapy processes.