FlexAct® - The new benchmark for operational flexibility
FlexAct® is a new system that enables you to custom- configure single-use solutions for entire biomanufacturing steps. The FlexAct® system consists of the central opera- ting module that offers the widest variety of configuration options so you can take complete control of practically any steps in upstream and downstream processing.
Sartorius Stedim Biotech presents the FlexAct® BP for buffer preparation. Next in line are media preparation (MP), cell harvest (CH), UF | DF crossflow (UD), virus removal (Vr), virus inactivation (VI), polishing (PO), form | fill (FF) and form | transfer (FT).
The core of FlexAct®, the central operating module (COM), has been designed to be used in any application. This means you can quickly reconfigure FlexAct® in just a few easy steps. For example, take the FlexAct® BP for buffer preparation and effortlessly convert it into FlexAct® VR for virus removal.
And it goes without saying that the technologies and products used in FlexAct® are scalable. This makes FlexAct® a future-proof system in every respect; one that gives you the greatest possible flexibility.
From basic label design and printing to advanced import and editing options, LabelMark software improves the label-making experience for the electrical, industrial, aerospace, laboratory and telecom industries.
New LabelMark™ 6 software takes the hassle out of designing and printing labels. With an improved user interface and app-based navigation combined with Brady’s proven interactive label creation and single-click importing and serialization, you have high performance label printing that has never been easier.
Label Printing with an improved user interface:
Easy-to-use apps for creating wire harness, control panel and laboratory labels
Insert and edit AutoCAD layers, area of interests or entire files
Automatically repeat text on multiple lines of a label with LabelMark wire marker tool
Multi-label view for true representation of label formats
Adjust each individual label’s length in your print file
Quickly import data onto a label from an external data source
One-step serialization of data
“Check error” function to locate any import errors in prior to printing
Assign label materials to a specific printer for dedicated printing
Manage multiple files in a single job by grouping wire markers, push buttons, rating plates, and terminal block labels into one job file
Bi-directional communication with the IP, BMP®41, BMP®51,BMP®53, BMP®71 and BBP®33 printer series for automatic label format loading
The Development Microlute™ from Porvair Sciences is a Solid Phase Extraction (SPE) microplate which provides a wide assortment of phase chemistries and sorbent loadings in a single plate making it ideally suited for method development.
Offering scientists a choice of up to 12 different phases and sorbent loadings (10 -100mg) in a standard format 96-well plate the Development Microlute™ allows you to simply and rapidly screen for the optimal retention and selectivity required to achieve your sample preparation objectives. By providing a complete SPE methods development solution that does not need to be constructed by the user, the Development Microlute™ delivers considerable savings in valuable laboratory time.
The Development Microlute™ has been designed to provide all the advantages of automated and high throughput SPE sample preparation in a convenient microplate format capable of rapidly processing 96 samples in one go repeatedly and precisely. Constructed from a single piece of molded high quality polypropylene, a Development Microlute™ plate will not bend or distort because individual SPE cartridges do not have to be repeatedly plugged in and out. Using a proprietary sorbent slurry loading technique, Porvair has eliminated the channeling effects often limiting the performance of dry powder loaded SPE columns. Each well on a Development Microlute™ plate has an individual drain spout ensuring 100% sample transfer and zero crossover contamination.
Working closely with the leading automated liquid handling companies has ensured that Porvair Development Microlute™ plates deliver high productivity, trouble-free operation with all robotic sample handling and preparation systems.
The Octet platform includes instruments, biosensors, reagents and assay kits for analysis of biomolecular interactions in 96- and 384-well microplates.
Octet systems enable real-time, label-free analysis for determination of affinity, kinetics and concentration. Significantly easier, faster and better characterization of drug candidates is possible, providing greater value in drug development applications where existing methods have limitations in throughput, performance and cost.
Label-Free, Real-Time Results. Our proprietary Bio-Layer Interferometry (BLI) technology monitors the binding of proteins and other biomolecules to their partners directly in real time.
Higher Throughput. Octet systems perform sample analysis in 96- and 384-well microplates, processing up to 96 samples in parallel. Protein quantitation of 96 samples can be completed in as little as two minutes — a task that can take from 4 hours to overnight using traditional ELISA. Rapid kinetics, screening and epitope binning assays are enabled by the multiplexed biosensor formats.
High Quality Data at an Affordable Price. Octet systems provide definitive analysis of kinetic binding constants at a fraction of the price of traditional SPR systems.
Crude Sample Compatibility. Proteins can be assayed in crude mixtures such as cell lysates or hybridoma supernatants, glycerol, or in up to 10% DMSO, which drastically reduces sample preparation.
Cytation 3 is an automated digital microscope that provides high quality cellular imaging up to 60x in slides, microplates, Petri dishes and cell culture flasks.
Cytation™ 3 cell imaging multi-mode system combines automated digital microscopy and conventional multi-mode microplate detection in one instrument. This unique patent pending design provides rich phenotypic cellular information with well-based quantitative data, bringing cell biology research to a new level.
Fully integrated solution for automated fluorescence and brightfield microscopy of slides, microplates and flasksTemperature control to 45°C, CO2/O2 gas control and orbital shakingPowerful yet easy to use software for efficient image capture and analysisEliminates inconveniences commonly associated with conventional microscopy
The modular platform can easily upgrade to add conventional multi-mode microplate detection, to provide well-based intensity data along with phenotypic information from the microscope.
To fulfill its responsibility towards the consumer, BIOTECON Diagnostics decided to develop high-quality detection kits for food allergens.
To fulfill its responsibility towards the consumer, BIOTECON Diagnostics decided to develop high-quality detection kits for food allergens. Therewith, the well-known and respected spectrum offoodproof® real-time PCR kits is extended by another interesting product division.
The first allergen kits that will be launched by the company from Potsdam, Germany, are the foodproof® Celery Detection Kit and the foodproof® Gluten Detection Kit. More allergen kits for the detection of soy, peanut and hazelnut will follow soon. In combination with the foodproof® Sample Preparation Kit III for theextraction of plant DNA, this kits allows simple and safe detection of allergens in all kind of foods. Depending on the source of literature the prevalence of food allergies is between 2 – 4 % for adults and 4 -8% for children.
The foodproof® Sample Preparation Kit III allows the extraction of highly purified DNA even from complex foods or processed matrices. To validate the foodproof® Allergen Detection Kits final products, raw materials and swab samples have been successfully tested. The kit cannot be only used for foods, finished products and raw materials, but also for cleaning validations. In addition, BIOTECON Diagnostics has developed a standardized reference material, Allergen RM 800, to create a standard curve for exact quantification.
More allergen kits for the detection of mustard, sesame, lupine and crustacean will be developed next year. Also it is planned to develop multiplex kits, to detect up to three different allergen-parameters within one reaction.
Food allergens became more important, because the frequency in the population has grown in the last decades. The reasons are still not totally clear; often it is credited to changing environmental influences and diets. Even the smallest amounts of allergens can cause severe allergic reactions up to life-threatening symptoms. For the consumer, the only protection is avoidance. According to EU-regulation 2007/68/EG 14, different allergenic ingredients have to be labeled in Europe on the products. Until now there is no threshold value in Europe or elsewhere. Therefore, the zero tolerance rule applies, even foods that only contain traces of allergens have to be labeled accordingly.
Dr. Kornelia Berghof-Jäger, Chief Executive Officer (CEO) of the Germany-based corporation BIOTECON Diagnostics therefore announced that „the expansion of our product portfolio by test kits for the detection of food allergens is a consequent continuation of our strategy to cover all aspects of food safety diagnostics bymolecular methods.“
„The new product line allows the users of our foodproof® system to enter new markets with the existing laboratory equipment without any additional financial investments.” emphasizes Alois Schneiderbauer, Chief Business Officer (CBO) of BIOTECON Diagnostics stated.
Labfors with LabCIP, the world’s first self-cleaning, self-sterilising bench-top bioreactor, is revolutionising the biotechnology industry.
Now the LabCIP is available in a new design: the smaller housing can be stowed away to save space, yet retains its full functionality. It means that INFORS HT offers the modern researcher not only significant time savings, but also more space in the lab.
The Labfors with LabCIP bench-top bioreactor is revolutionising the biotechnology industry. As the world’s first self-cleaning, self-sterilising bench-top bioreactor, it not only saves users the tiresome job of cleaning and sterilising the bioreactor but also doubles the throughput rate. The LabCIP can perform its work overnight, making the Labfors ready to use again first thing the next day. This reduces the down time of the bioreactor to a minimum, allowing users to concentrate on their research.
And now the LabCIP is available in a new design: the reduction in overall height, allowing it to be stowed away to save more space, while retaining full functionality. It means that INFORS HT offers 21st Century capability in two key areas - saving time AND space.
Product, performance and packaging: The New Eppendorf cell culture consumables deliver quality in all and offer a new dimension of safe, reproducible and reliable cell culture work.
Scientists and technical personnel in the field of cell culture have a strong need for easy, safe and reliable products with improved handling that help prevent contamination. The latest products from Eppendorf deliver exceptional levels of product purity and security, as well as improved, ergonomic and safe handling of cell cultures and advanced protection against contamination. The new, easy resealable packaging concept complements the products’ unique features and performance.
Eppendorf Cell Culture Consumables are made from ultraclear virgin polystyrene, which complies with USP class VI for highest purity. Cell Culture Consumables have a ISO class /GMP class C clean room production standard and a sterility assurance level (SAL) of 10-6 as well as batch specific 3rd party quality testing ensuring exceptional product and sample safety.
Innovative technologies in Eppendorf Cell Culture Consumables deliver ultimate ease of use. New high efficiency air filter technology in Eppendorf flasks provides improved contamination protection, while ConvexAccess™ neck geometry allows more ergonomic handling and facilitated entry into flasks. Meanwhile, a corrugated handling ring and new SplashProtect™ ring in dishes deliver safe, confident handling and better protection against contamination. Finally, Eppendorf’s new chimney well design in plates minimizes the “edge effect” and leads to more reproducible assay results.
Many cell culture applications require the constant use of a sterile safety cabinet, which often has a limited amount of space available. Eppendorf’s new packaging concept addresses this limitation through easy opening, truly resealable and shrinkable design, allowing safe storage and requiring less space, while an innovative tray allows easy removal of the products from the box and safe workflows.
For convenient and secure sterile connection of flexible tubing in large volume operations.
Kleenpak II sterile connectors allow for the dry connection of two separate fluid pathways, while maintaining the sterile integrity of both, even in an uncontrolled environment. The connector consists of a male and a female connector, each covered by an aluminum peel-away strip that protects the port and maintains the sterility of the sterile fluid pathway prior to connection.
The Kleenpak II sterile connector has been designed to allow for the connection of large processing equipment in order to obtain fast, safe and reliable sterile transfer of large volumes.With this sterile connector, large single-use systems ( > 100 L), such as the AllegroTM systems, will be operated at much faster speeds. There will be minimal fluid restriction in thetubing lines.
Different connector options are available to allow for the connection of 19 mm (3⁄4 in.) and 25.4 mm (1 in.) ID nominal tubing including a 25.4 - 38.1 mm (1 - 11⁄2 in.) sanitary flange compatible fitting for maximum operational flexibility. Kleenpak II sterile connectors can be either gamma irradiated to a maximum of 50 kGy or autoclaved up to 130°C to suit different processing requirements.
The µDAWN™ Multi-Angle static Light Scattering (MALS) detector performs absolute characterization of macromolecules eluting from UHPLC, determining molar mass and size independently of retention time and molecular reference standards.
The µDAWN™ Multi-Angle static Light Scattering (MALS) detector performs absolute characterization of macromolecules eluting from UHPLC, determining molar mass and size independently of retention time and molecular reference standards. This instrument offers superb sensitivity over a wide range of molar mass, size and concentrations. In most respects the µDAWN is similar to the well-established miniDAWN™ TREOS™, a workhorse MALS instrument used in hundreds of labs around the world for characterizing proteins and other molecules smaller than 50 nm in radius.
Distinctly from the miniDAWN, the µDAWN is uniquely suitable for use in conjunction with UHPLC Size Exclusion Chromatography (µSEC-MALS) thanks to its small interdetector dispersion. In some cases it may be used with ion-exchange or other types of chromatography. Regardless of the specifics, the µDAWN produces minimal band broadening in order to maintain the narrow peaks typical of UHPLC.
The µDAWN may also be used in microbatch (off-line) mode or in conjunction with a Calypso IICG-MALS system for characterization of macromolecular interactions: affinity and absolute stoichiometry, label-free and immobilization-free, as well as second virial coefficients, cross virial coefficients, average molar masses and sizes.
More background reports, more interviews and as always, news from all the European regions: Discover our newly relaunched 2014 Autumn Issue, with in-depth reports on cancer immune therapy, biorefineries, biosimilars. more