03.06.2013 - GlaxoSmithKline’s multi kinase blocker pazopanib has increased progression free survival in women with advanced ovarian cancer by 5.6 months.
At the ASCO meeting, the British drug major reported that the median time to disease progression under the VEGFR, PDGFR, c-KIT blocker post-surgery and chemotherapy was 17.9 months, compared with 12.3 months in patients receiving placebo. GSK announced that it will file an MAA in the US for pazopanib as first-in-class maintenance therapy after surgery and chemotherapy. In contrast to Europe where Roche’s bevacizumab is approved as maintenance therapy, there is no comparable treatment approved by the FDA.
91% of the 940 patients with advanced epithelial ovarian cancer had stage III/IV disease at diagnosis and no residual disease following surgery. While efficacy was shown, more serious adverse drug effects were observed in the pazopanib group (26%) than in the placebo arm (11%) of the study.
29.07.2015 Newly founded Mereo BioPharma has acquired three mid-stage clinical assets from Novartis. In turn, the Swiss pharma concern will hold a stake in the UK company. Other investors are also on board.
24.07.2015 Biotech companies across Europe continue to raise cash on the public markets, generating €3bn in total financing proceedings in the first half of 2015. Compared to 2014, this is almost twice as much.
23.07.2015 US money keeps flowing into Europe's biotechs. As the race for the peanut allergy market heats up, NASDAQ listed French biotech DBV has announced the successful closing of US$281m (€256m) share offering for its allergy products.
16.07.2015 Sanofi has announced plans to restructure its business in five standalone global business units starting in January 2016. The goal is to promote growth and help the company launch a catalogue of new drugs over the next five years.
15.07.2015 GlaxoSmithKline (GSK) has become the first drugmaker to join the Francis Crick Institute. It is a consortium made up of six scientific and academic institutes to conduct research and drug development in the UK. The new institute is set to become a world-leading centre of biomedical research and innovation.
10.07.2015 Karolinska Development has slashed the reported value of its portfolio by almost half by revising its valuation model for early stage companies and divesting its shares in pain med maker Pharmanest.
The BioShake series contains high-speed mixer and thermal mixer for small and very small volumes in microplates and reaction tubes and allows for the first time high precise and efficient mixing in the microliter scale for a wide range of applications. more