17.04.2013 - Danish Santaris Pharma A/S has entered a global strategic R&D collaboration with BristolMyers Squibb in the field of RNA drugs.
Santaris said it will use its Locked Nucleic Acid (LNA) platform to discover and develop new mRNA or microRNA drug candidates. Under the terms of the agreement, the Horsholm-based company will get US$10 upfront and up to US$90m of milestone payments. Furthermore, the drug developer will be eliglible to receive royalties on worldwide sales araising from the alliance.
In successful cases, BMS will gain the exclusive global marketing rights. Further financial details were not disclosed by the companies. Santaris Pharma's LNA platform A/S combines the company's proprietary LNA chemistry with its highly specialised and targeted drug development capabilities to rapidly deliver LNA-based drug candidates against RNA targets, both mRNA and microRNA, for a range of diseases including infectious and inflammatory diseases, cardiometabolic disorders, cancer and rare genetic disorders.
RNA-based drugs are a promising new class of therapeutics that are enabling scientists to develop drug candidates that target previously inaccessible clinical pathways. The LNA Drug Platform overcomes the limitations of earlier antisense and siRNA technologies to deliver potent single-stranded LNA-based drug candidates across a multitude of disease states
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