12.06.2013 - Norway’s cancer radiotherapy specialist Algeta has signed an agreement with Australian antibody developer Avipep Pty Ltd.
Under the terms of the agreement, the Algeta ASA will evaluate a conjugate that couples the Oslo-based company’s alpha-emitter thorium-227 to Avipep’s Avibody, which targets a number of different solid tumour types. The thorium payload, which triggers DNA double-strand breaks that lead to cell death, have been shown to be highly localised, minimising off-target effects. Algeta has coupled the radionuclide to different cancer-targeting molecules such as Her2 and PDGFRβ.
Avipep will provide access to one of its proprietary Avibodies, which the company uses for targeting and labelling tumour cells. Algeta will provide access to chelation and conjugation technologies, as well as to its alpha particle-emitting payload thorium-227. Both companies will contribute financially to the collaboration, which is expected to last for up to one year initially with the option for further cooperation thereafter. No further terms have been disclosed. Algeta runs already collaborations with Genzyme and Affibody AB to develop Targeted Thorium Conjugates (TTC). After having brought its alpha-emitter radium-223 dichloride to the market, the company now seeks to evaluate targeted approaches of its technology. In contrast to cytotoxic payloads, TTC’s offer the advantage of not being subject to drug resistance.
27.04.2016 More revenue, more jobs, more financing, more R&D expenditure – all signs point towards sustainable growth in the German biotech sector. These are the results of the most recent company survey 2016, published by biotechnologie.de. The report was once again conducted alongside the biotech standards defined by the organisation for economic cooperation and development (OECD).
21.04.2016 An expert panel’s final report on the fatal drug trial earlier this year in France states that the death of one of the participants was most likely caused by the drug’s toxicity and not by any violation of the rules.
21.04.2016 For up to US$685m (€606m), Dutch ArgenX has outlicensed its human antibody programme ARGX-115 to AbbVie. The pre-clinical immuno-oncology candidate targets a protein believed to contribute to immunosuppressive effects of T-cells.
19.04.2016 British drug developer Heptares Therapeutics and mAb maker Kymab Ltd have partnered up in yet another immuno-oncology collaboration. The companies plan to discover antibody meds targeting a superfamily of receptors.
15.04.2016 Not every company is put off by the current stock market climate. Swiss biopharma company GeNeuro has gone public at Euronext Paris, raising €33m in the process. Others, meanwhile, have to find different ways to raise money.
13.04.2016 Despite political disturbances, 2015 was a good year for the biotech scene in Switzerland. Net sales increased by 5.1% to CHF5,133m and 400 additional people found jobs in the sector. As usual, the new numbers were presented at the annual Swiss Biotech Day – which set new records as well.
12.04.2016 German-Dutch life science investment specialist Forbion Capital Partners has raised more than €180m for its venture capital fund Forbion Capital Fund III. Once more the money will primarily go to European start-ups.
08.04.2016 Do you win by being innovative?, was the question asked at this year’s DIA Euromeeting in Hamburg. In a relaxed and cooperative atmosphere, regulators, physicians and patients had ample opportunity to interact with the healthcare industry.
07.04.2016 Pfizer and Allergan have called off their merger, cancelling plans to relocate the US pharma giant to Ireland to avoid US taxation. The US government has put a spoke in Pfizer’s wheels - an unfair move, Allergan says.