News

Merck Serono bags MS licence option
Enlarge image

BusinessGermany

Merck Serono bags MS licence option

06.02.2013 - Merck Serono has secured an exclusive licence option for Opexa Therapeutics’ autologous T cell-based Multiple Sclerosis therapy imilecleucel-T.

Opexa’s Tcelna (imilecleucel-T) therapy currently is tested in a Phase IIb study on patients with Secondary Progressive MS (SPMS), which is less common than relapsing forms of MS that are targeted by Merck’s blockbuster Rebif® (interferon beta-1a)  In case of market entry and successful commercialisation, the US firm could gain US$225m in total from the option and license agreement.

Under the terms of the contract, Opexa will receive an upfront payment of $5 million for granting an option to Merck Serono for the exclusive license of the Tcelna (imilecleucel-T) programme as a treatment of MS. The option may be exercised prior to, or upon completion of, Opexa’s proof-of-concept trial. If Merck Serono opts for the programme, Opexa is eligible for $25m or $15m upfront depending on fulfilment of certain undisclosed conditions. The Germans, in return, would receive worldwide development and commercial rights in MS, excluding Japan. When exercising the option, Merck Serono would have to pay all clinical development, as well as the cost for regulatory authorisation and marketing of the MS programme. Milestone payments to Opexa could sum up to $195m plus a tiered royalty rate from the high single digits to the mid-teens based on net sales.

Under the agreement, Opexa will have an option right to co-fund development, under which the company would participate in economic support for future clinical development of the programme in exchange for additional royalty consideration. In addition to retaining all rights outside of MS as well as retaining the ability to commercialise imilecleucel-T in Japan, Opexa also retains certain manufacturing rights related to the programme. 

Tcelna (imilecleucel-T) is an autologous T cell therapy. After collection of peripheral blood mononuclear cells, myelin-reactive T-cells (MRTCs) raised against selected peptides from myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG) and proteolipid protein (PLP) are expanded, irradiated and given back to the patient subcutaneously to trigger a therapeutic immune response.

© eurobiotechnews.eu/tg 

http://www.european-biotechnology-news.com/news/news/2013-01/merck-serono-bags-ms-licence-option.html

BusinessUK

20.08.2014 Biopharmaceutical contract manufacturer Fujifilm Diosynth Biotechnologies is expanding its cell culture manufacturing capacity further with a new 2,000l single-use bioreactor at the company’s site in Billingham, UK.

BusinessEUGermanyUK

15.08.2014 Some of Europe’s biggest pharma companies are competing in a bidding war for US biotech Intermune Inc., Bloomberg reports, citing insider reports as the source.

ResearchEUGermanyUK

13.08.2014 The Ebola epidemic is still raging on in West Africa and thus far there is

neither vaccine nor cure for the viral disease. The only flickers of hope:

an experimental antibody serum and an early-stage vaccine.

BusinessFrance

11.08.2014 Will Sanofi succeed where Pfizer failed? The French pharmaceutical company has taken on the commercialisation of Mannkind Corporation’s inhaled insulin product Afrezza.

ResearchSwedenGermany

08.08.2014 Boehringer Ingelheim is walking away from Swedish Orexo's prostaglandin inhibition project OX-MPI. Germany's largest researching pharmaceutical company had been responsible for the project's research and development since 2005.

ResearchSwitzerlandDenmark

06.08.2014 Roche is re-expanding its involvement in RNAi technologies. The Swiss pharmaceutical company will pay up to €335m for the acquisition of the Danish company Santaris Pharma A/S.

ResearchUKSwitzerland

03.08.2014 In its efforts to become the leading country in genetic research, the UK has attracted investments worth more than £300m (€376m) to map 100,000 human genomes by 2017.

BusinessSpainUKSweden

31.07.2014 Astrazeneca is buying the rights to Almirall’s respiratory drugs in a deal worth up to €1.56bn.

BusinessFranceGermanySwitzerlandUK

30.07.2014 Rumours have it that French Danone wants to sell its medical nutrition business to US drugmaker Hospira for US$5bn in yet another tax inversion deal.

Events

All Events

Current issue

All issues

Product of the week

Products

Stock list

All quotes

TOP

  • 4SC1.23 EUR6.03%
  • VITA 343.96 EUR4.49%
  • WILEX2.36 EUR4.42%

FLOP

  • CYTOS0.26 CHF-3.70%
  • MOLOGEN7.10 EUR-2.74%
  • ADDEX4.00 CHF-1.72%

TOP

  • SANTHERA82.95 CHF19.7%
  • MAGFORCE6.50 EUR10.2%
  • LONZA101.10 CHF7.1%

FLOP

  • MOLOGEN7.10 EUR-24.5%
  • WILEX2.36 EUR-24.4%
  • 4SC1.23 EUR-15.2%

TOP

  • SANTHERA82.95 CHF3850.0%
  • CO.DON2.50 EUR228.9%
  • PAION2.48 EUR198.8%

FLOP

  • CYTOS0.26 CHF-93.5%
  • MEDIGENE4.65 EUR-67.7%
  • MERCK KGAA64.40 EUR-45.7%

No liability assumed, Date: 21.08.2014