News

Enlarge image

BusinessUK

Cubist bags GPCR drug

08.01.2013 - US-based Cubist Pharmaceuticals and British Heptares sealed a €7.2m license deal. Cubist pays to snatch a drug candidate for an undisclosed GPCR target.

The small spin-off Heptares Therapeutics from Welwyn Garden City north of London has landed a license deal with US biopharma Cubist Pharmaceuticals, Inc. Heptares’ area of expertise are G-protein coupled receptors (GPCR). Cubist will pay €4.2m up front and €3.1m in research funding plus undisclosed milestone payments and royalties. Heptares, in return, uses its proprietary platform technology to screen for drug candidates targeting an unnamed GPCR specified by Cubist. The deal also includes an option for a second target. Financial details covering that part of the collaboration have been predetermined – but will not be made public. Both parties agreed that the preclinical development will be carried out solely by Cubist.

Heptares was spun off from the Medical Research Council in 2007. The company engineers stabilised GPCRs (so-called STaRs), circumventing the problematic handling of the otherwise labile receptors. The UK firm entered biopharma main stage only last spring when it became eligible to receive payments potentially equalling €145m. Back then Irish Shire plc licensed a Heptares-discovered preclinical antagonist of the GPCR A2A (see photo) which could turn to a new CNS disorders medicine. Also AstraZeneca and Novartis belong to Heptares’ customers.

© eurobiotechnews.eu/ml

http://www.european-biotechnology-news.com/news/news/2013-01/cubist-wants-gpcr-drug-by-heptares.html

CommercialisationEU

10.02.2016 In future, meds will come in packages sporting a unique barcode and an anti-tampering device. These measures are part of the EU’s new regulation to safeguard against falsified medicines.

Clinical ResearchFrancePortugalEU

05.02.2016 It is not yet clear why a man died during a first-in-man clinical trial in January. A preliminary report found several “major shortcomings” by responsible CRO Biotrial. However, all regulations were complied with.

M&ASwitzerland

04.02.2016 After having dodged multiple takeover attempts by Monsanto last year, agrobusiness giant Syngenta has now agreed to be acquired by chemical corporation ChemChina. The Swiss company also announced plans to go public within a few years.

FinancingEUUKBelgium

01.02.2016 Newly formed Medicxi Ventures, a life sciences-dedicated VC firm based in London, Geneva and Jersey, has closed a €210m investment fund to reinvest in European early-stage assets.

ResearchUKEU

01.02.2016 Altering human DNA with the efficient gene editing method CRISPR/Cas9, especially germline modifications, was long considered a taboo. Now, however, UK scientists have received official approval to tinker with embryo DNA.

M&ASwedenIceland

28.01.2016 Swedish infectious disease specialist Enzymatica has bagged Icelandic company Zymetech, who produces the patent-protected enzyme used in Enzymatica’s own common cold blocker ColdZyme.

R&DUK

27.01.2016 Three UK universities have teamed up with three pharma companies to create the Apollo Therapeutics Fund. With the tech transfer fund, the consortium aims to develop scientific research into medicines.

Clinical TrialsGermany

25.01.2016 Affimed means to put a promising drug combination to the test. With support from MSD, the German biopharma will carry out clinical trials for an immunotherapy combining treatments of both companies.

AMREU

21.01.2016 Stop squandering antibiotics and make research profitable again: at the World Economic Forum in Swiss Davos, 83 pharmaceutical companies have called for a unified approach towards the threat of antimicrobial resistance.

M&AFinland

19.01.2016 Biotie Therapies has long been expanding its business in the US. Now, the Finnish company is set to be taken over by US company Acorda Therapeutics, which is paying €321m for the shares.

Events

All Events

Current issue

All issues

Product of the week

Products

Stock list

All quotes

TOP

  • THERAMETRICS (CH)0.05 CHF25.00%
  • ZEALAND PHARMA (DK)105.50 DKK14.05%
  • SARTORIUS (D)244.45 EUR12.88%

FLOP

  • PAION (D)1.25 EUR-36.55%
  • SWEDISH ORPHAN BIOVITRUM (S)12.45 USD-23.38%
  • BIOTIE THERAPEUTICS (FI)0.14 EUR-22.22%

TOP

  • VERONA PHARMA (UK)3.30 GBP24.5%
  • IXICO (UK)35.75 GBP21.2%
  • SAREUM HOLDINGS (UK)0.30 GBP15.4%

FLOP

  • BIONOR PHARMA (N)0.81 NOK-52.9%
  • PAION (D)1.25 EUR-48.6%
  • CYTOS (CH)0.25 CHF-34.2%

TOP

  • CHRONTECH PHARMA (S)0.34 SEK3300.0%
  • KARO BIO (S)24.50 SEK3081.8%
  • NICOX (F)6.80 EUR245.2%

FLOP

  • NEUROVIVE PHARMACEUTICAL AB (S)8.65 SEK-85.8%
  • BIOTEST (D)13.40 EUR-85.5%
  • EVOCUTIS (UK)0.08 GBP-71.4%

No liability assumed, Date: 10.02.2016