News

Nanobodies, megapayoff
Enlarge image

BusinessBelgium

Nanobodies, megapayoff

04.10.2012 - Belgian Ablynx secures €8.5m upfront from Merck Inc. for the development of Nanobodies against two targets, one of them yet unknown.

Camelidae antibody developer Ablynx NV (Ghent) has inked a collaboration with US pharma major Merck & Co. Inc (MSD). The companies collaborate primarily to develop and commercialise Nanobody® candidates directed towards a certain voltage-gated ion channel. Merck also acquired the option to do the same for a second, as yet unknown, target. The deal includes a €6.5m upfront payment and another €2m compensation for research funding. With successfully passed regulatory and commercial milestones in addition to secured royalties, Ablynx will be eligible to receive up to €448 million in total. While Ablynx is in charge of the discovery of the Nanobodies, Merck gains the exclusive global rights to market them and is responsible for research, development, manufacturing and commercialisation of any Nanobody® product resulting from the collaboration. 

After Ablynx showed the proof-of-principle in 2011, things are going well for the company despite the withdrawal of US pharma giant Pfizer almost a year ago. Edwin Moses, Chairman and CEO of Ablynx commented on the new deal: "We are delighted to initiate this collaboration with Merck in the area of ion channels, where to date, monoclonal antibodies have demonstrated little success. Due to the formatting flexibility of Nanobodies, we are able to combine antibody-like selectivity and multi-specificity in one molecule, making them ideal candidates for ion channel modulators." Nanobodies® are a novel class of therapeutic proteins based on single-domain, heavy-chain antibody fragments. They link conventional monoclonal antibody advantages like high specificity with the benefits of small molecule drugs like low sensitivity to temperature and pH changes. So far, Ablynx has approximately 25 programmes in the pipeline, and seven Nanobodies at clinical development stage, including partnerships with pharma and biotech companies like Boehringer Ingelheim (cancer, Alzheimer’s), former Merck Serono (osteoarthritis), Novartis, and Merck & Co.

© eurobiotechnews.eu/ml

http://www.european-biotechnology-news.com/news/news/2012-04/nanobodies-megapayoff.html

M&AUKSweden

24.08.2016 Pharma major Pfizer is putting the cherry on top of its multi-billion-dollar takeover of Medivation with the acquisition of AstraZeneca’s antibiotics for a cool US$1.5bn. With the divestment, AZ aims to further sharpen its focus.

FinancingUK

23.08.2016 Cambridge University-allied investor Cambridge Innovation Capital has raised £75m (€87m) to reinvest in technology and healthcare companies. Among the backers were Woodford Investment and Winton Ventures.

R&DDenmark

19.08.2016 Together with partner Johnson & Johnson, Danish biotech Genmab is now one step closer to FDA approval with its combination treatment for multiple myeloma after its submission of a supplemental Biologics License Application. In July, Genmab was granted a Breakthrough Therapy Designation (BTD) for its blood cancer therapy.

ResearchUKEU

17.08.2016 Philip Hammond, the UK’S chancellor has announced the government will guarantee funding for EU-backed "structural and investment fund" projects whose timelines extend beyond the UK’s departure from the EU, provided the projects are signed prior to this year's Autumn Statement on the UK budget. The decision ensures continued funding for farmers, companies and institutions involved in the EU’s Horizon 2020 project. The move could cost the UK government up to £6bn (€6.9bn).

Stock marketsGermany

15.08.2016 Back in April, the American FDA gave the green light for the colorectal cancer-screening test Epi procolon. Now Berlin-based diagnostics specialist Epigenomics is considering a secondary listing in the US. A draft of the required registration document was confidentially submitted to the US Securities and Exchange Commission (SEC).

LicensingDenmark

11.08.2016 Danish Genmab AS has granted Gilead Sciences license to use its DuoBody technology platform to develop bispecific antibodies for the treatment of HIV. The deal is worth up to €252m.

Clinical developmentHungaryIreland

09.08.2016 Hungarian Gedeon Richter and Irish Allergan are staying on course in the face of dissappointing Phase III results for depression drug cariprazine. The partners will now begin another Phase III study needed for approval.

ImmunotherapySpain

08.08.2016 Araclon Biotech’s Alzheimer’s vaccine ABvac40 is going forward into Phase II after showing a good safety profile in Phase I. The promising trial results were presented at the Alzheimer’s Association International Conference.

ApprovalEU

04.08.2016 After a two-year pilot period, the EMA has published its report on its adaptive pathways approach. The agency plans to “explore the concept further” and will continue to accept proposals.

BusinessPolandUK

01.08.2016 Life science venture capital group Epidarex has launched Nodthera Ltd, a biotech based on research by Poland-based drug discovery company Selvita. The start-up aims to develop novel inhibitors of the NLRP3 inflammasome.

Quick news provided by GlobeNewswire

View more stock news

Events

All Events

Partner-Events

Current issue

All issues

Product of the week

Products

Stock list

All quotes

TOP

  • NEWRON (CH)22.65 CHF9.69%
  • VERNALIS (UK)45.00 GBP4.65%
  • KARO BIO (S)40.00 SEK4.44%

FLOP

  • PROTHENA PLC (IE)50.02 USD-7.70%
  • FLAMEL TECHNOLOGIES (F)13.85 USD-6.98%
  • BIONOR PHARMA (N)0.44 NOK-6.38%

TOP

  • DIAMYD MEDICAL -B- (S)7.25 SEK68.6%
  • KARO BIO (S)40.00 SEK34.2%
  • NEWRON (CH)22.65 CHF33.6%

FLOP

  • BIONOR PHARMA (N)0.44 NOK-27.9%
  • NOVOZYMES (DK)284.40 DKK-14.0%
  • RENEURON (UK)2.75 GBP-12.7%

TOP

  • KARO BIO (S)40.00 SEK2497.4%
  • NICOX (F)10.26 EUR451.6%
  • SAREUM HOLDINGS (UK)0.74 GBP252.4%

FLOP

  • BB BIOTECH (D)46.74 EUR-81.7%
  • EVOCUTIS (UK)0.04 GBP-78.9%
  • NEUROVIVE PHARMACEUTICAL AB (S)5.50 SEK-71.4%

No liability assumed, Date: 24.08.2016