News

AstraZeneca buys miRNA know how
Enlarge image

BusinessUKSweden

AstraZeneca buys miRNA know how

16.08.2012 - British-Swedish pharma giant AstraZeneca has inlicenced three miRNA targets from Regulus Therapeutics.

AstraZeneca said it will make an US$28m upfront payment and equity investment for the exclusive commercialisation rights for compounds directed against three miRNA targets identified by the US joint venture of Alnylam and Isis Pharmaceuticals. The deal includes Regulus’ lead programme that targets miRNA33 in atherosclerosis. Three other programmes will be focused on cardiovascular (miRNA24) and metabolic diseases as well as cancer. Under the terms of the agreement, Regulus will lead preclinical development, whereas AstraZeneca will be responsible for clinical development and commercialisation. In case of success, Regulus will receive preclinical and clinical milestones and royalties.

Atherosclerosis is the build-up of plaque that occurs when cholesterol and inflammatory cells accumulate in blood vessels. These plaques can rupture, leading to slowing or blockage of blood flow and ultimately resulting in a heart attack or stroke. Scientific research has shown a strong correlation between high cholesterol levels and cardiovascular disease which, according to the Centers for Disease Control, is the leading cause of death in the United States.

Regulus’ lead program for atherosclerosis targets microRNA-33, which has a unique mechanism of action for the management of cholesterol levels. The inhibition of microRNA-33 with our anti-miRs promotes reverse cholesterol transport, or RCT, which is the efflux of cholesterol from specific cholesterol-laden inflammatory cells called macrophages in atherosclerotic plaques. Treatment with anti-microRNA-33 in an atherosclerotic mouse model led to reduction in arterial plaque size by 35% (Rayner et al., J Clin Invest. 2011) and treatment in non-human primates increased circulating levels of HDL-C by 50%. By enhancing RCT, anti-miR-33 differs from other emerging therapeutic strategies that focus only on raising HDL-C in circulation.

http://www.european-biotechnology-news.com/news/news/2012-03/astrazeneca-buys-mirna-know-how.html

Swiss Biotech DaySwitzerland

16.04.2015 The Swiss biotech industry can look back on 2014 as a good year, but political uncertainties do remain. This was one of the topics discussed during the Swiss Biotech Day in Basel, which attracted more than 400 participants.

EventEUFrance

16.04.2015 The changing landscape in healthcare was just one of the hotly discussed topics of the 27th Annual EuroMeeting of the international association DIA.

R&DBelgium

14.04.2015 Belgian Thrombogenics NV has launched a new oncology company with Gent-based life sciences institute VIB. The new venture will develop an antibody for the treatment of a fast-growing brain tumour that affects children and adolescents.

Stock MarketsEUFranceUKNorwaySweden

09.04.2015 The European public markets remain highly attractive for biotech companies. Twice as many companies went public in the first quarter of 2015 than during the same period last year.

FinancingAustriaUKSwitzerlandGermany

08.04.2015 To bring its lead product of a new class of antimicrobials to phase 3 trials, Nabriva Therapeutics has completed a US$120m Series B financing.

Research & DevelopmentNetherlands

07.04.2015 Gene therapy is attracting more and more big pharma companies. Now, Bristol-Myers Squibb has forged a US$1bn collaboration with Dutch uniQure, also picking up a 4.9% share in the company.

Stock MarketsFrance

02.04.2015 Sensorion is the latest French biotech to go public, following a spate of IPOs on Paris Euronext. The biopharma plans for a €12m IPO to finance its pipeline of inner ear disease drugs.

M&AIreland

31.03.2015 In its aim to expand its drug portfolio in orphan disease products, Horizon Pharma has acquired US company Hyperion Therapeutics for US$1.1bn in cash. The takeover entitles the UK biopharma to all of Hyperion’s common stock.

BusinessGermany

31.03.2015 Merck Serono has forged a US$941m (€876m) deal with US Intrexon for the development and commercialisation of CAR-T therapies. The new CAR-T projects are set to strengthen their R&D technology portfolio in immuno-oncology.

Stock MarketsFranceEU

27.03.2015 Europe is once more proving that it can be a good bet for biotech companies going public. A newly established EU-wide lobbying initiative could help the IPO boom on its way.

Events

All Events

Partner-Events

München

BioVaria 2015

Current issue

All issues

Product of the week

Products

Stock list

All quotes

TOP

  • MORPHOSYS64.50 EUR6.19%
  • CO.DON3.10 EUR4.38%
  • 4SC1.23 EUR4.24%

FLOP

  • THERAMETRICS0.07 CHF-12.50%
  • CYTOS1.24 CHF-3.12%
  • SANTHERA97.60 CHF-2.16%

TOP

  • 4SC1.23 EUR78.3%
  • MEDIGENE13.14 EUR67.0%
  • FORMYCON31.20 EUR31.9%

FLOP

  • THERAMETRICS0.07 CHF-12.5%
  • EPIGENOMICS5.32 EUR-10.4%
  • BB BIOTECH290.10 EUR-8.4%

TOP

  • SANTHERA97.60 CHF2649.3%
  • CYTOS1.24 CHF629.4%
  • FORMYCON31.20 EUR339.4%

FLOP

  • MOLOGEN5.11 EUR-52.7%
  • THERAMETRICS0.07 CHF-30.0%
  • BIOFRONTERA2.58 EUR-20.9%

No liability assumed, Date: 20.04.2015