News

Tasquinimod works, says Phase II study
Enlarge image

BusinessSwedenFrance

Tasquinimod works, says Phase II study

05.06.2012 - Swedish Active Biotech draws new hope from a Phase II result with prostate cancer drug tasquinimod.

Lund – Almost a year ago Swedish Active Biotech AB saw its stock value dwindling away when the oral multiple sclerosis drug laquinimod failed in crucial Phase III testing. Although the price per share has doubled when compared to the start of the year, SEK44 is still far away from its last 12-month-cycle climax roughly a year ago.

On 4 June, Andrew Armstrong from the Duke Cancer Institute in Durham (USA) presented data on a long-term follow-up of a randomised Phase II placebo-controlled trial with Active Biotech's tasquinimod. The talk, given at the 2012 ASCO Annual Meeting in Chicago (USA), focussed on the median overall survival times of patients suffering from castrate resistant prostate cancer (CRPC) which increased from 30.4 months (placebo) to 33.4 months (tasquinimod). Armstrong expressed that these findings surprised him: "Men with metastatic CRPC in this trial were unexpectedly found to have prolonged survival times, despite a high fraction of patients with liver and lung metastases."  

Active Biotech is developing the drug together with Ipsen group, a pharmaceutical company from Paris (France) employing 4,500 people. Ipsen's CSO Claude Betrand was eager to announce he's pleased with the results: "We are thrilled. The results underline the activity of the compound. With its differentiated mechanism of action [not targeting the androgen receptor pathway] we hope to propose an alternative treatment after the ongoing Phase III results have replicated these interesting findings." So far 600 patients have been recruited for the double-blind Phase III study. In the end the study will include 1,200 patients from more than 250 clinics.

http://www.european-biotechnology-news.com/news/news/2012-02/tasquinimod-works-says-phase-ii-study.html

PoliticsEU

15.09.2014 Jean Claude Juncker, the European Commission President-elect revealed his new Commissioners last week, whilst announcing a change in the units dealing with medicines, medical devices and health technology.

BiosimilarsGermanyFrance

12.09.2014 The 2011 collaboration of Boehringer Ingelheim and Eli Lilly is bearing fruit. An insulin biosimilar developed through the partnership has now been approved in Europe - the first-ever generic version of this class.

FinancingNetherlands

11.09.2014 Cystic fibrosis specialist Proqr Therapeutics has set the terms for its upcoming IPO at US-American stock exchange NASDAQ.

Clinical TrialsUKSweden

09.09.2014 In the midst of the hustle and bustle of the European Respiratory Society’s International Congress 2014, Astrazeneca quietly announced the disappointing results of its latest benralizumab study.

BusinessDenmark

04.09.2014 After their arthritis product’s Phase IIb failure, Novo Nordisk A/S is pulling out of all research and development activities within inflammatory disorders.

BusinessBelgiumIrelandSwitzerland

02.09.2014 In the face of declining revenue, Belgian biopharmaceutical company Thrombogenics has decided to spin out its cancer research and development activities.

ResearchUKSwitzerlandItaly

29.08.2014 Just a week ago, Glaxosmithkline defused the WHO’s claim that an Ebola vaccine could be ready by 2015. Now, the British company’s own candidate vaccine is to be rushed to human trials with the help of funding from an international consortium.

BusinessGermany

24.08.2014 Germany's Morphosys is licensing a preclinical bi-specific antibody for the treatment of prostate cancer from Emergent Biosolutions. The US developer will rake in up to €138m for the commercialisation rights to the compound.

BusinessUK

20.08.2014 Biopharmaceutical contract manufacturer Fujifilm Diosynth Biotechnologies is expanding its cell culture manufacturing capacity further with a new 2,000l single-use bioreactor at the company’s site in Billingham, UK.

Events

All Events

Current issue

All issues

Product of the week

Products

Stock list

All quotes

TOP

  • WILEX2.48 EUR3.77%
  • 4SC1.12 EUR2.75%
  • VITA 344.00 EUR2.04%

FLOP

  • ADDEX2.99 CHF-7.14%
  • BIOFRONTERA2.18 EUR-5.22%
  • SARTORIUS94.26 EUR-3.32%

TOP

  • SANTHERA92.00 CHF43.5%
  • CO.DON3.02 EUR26.9%
  • PAION2.98 EUR19.7%

FLOP

  • EVOTEC3.00 EUR-20.0%
  • ADDEX2.99 CHF-18.5%
  • 4SC1.12 EUR-15.8%

TOP

  • SANTHERA92.00 CHF2211.6%
  • CO.DON3.02 EUR247.1%
  • PAION2.98 EUR189.3%

FLOP

  • CYTOS0.24 CHF-94.0%
  • MERCK KGAA67.23 EUR-41.4%
  • THERAMETRICS0.09 CHF-40.0%

No liability assumed, Date: 16.09.2014