News

Shire attacks treatment monopoly of Sanofi
Enlarge image

BusinessFranceIrelandUK

Shire attacks treatment monopoly of Sanofi

29.06.2012 - For over a decade, Sanofi’s Cerezyme has dominated the market of therapies for Gaucher disease. Now, Shire challenges the drug with new results.

Dublin/Paris/ Carmiel/ Cambridge – Results from a head-to-head Phase III clinical study with Sanofi’s Gaucher disease therapy imiglucerase (Cerezyme) suggest that Shire’s enzyme replacement therapy velaglucerase alfa (VPRIV) offers a unique benefit to patients. According to the Irish drugmaker, only patients treated with VPRIV experienced statistically significant improvement in lumbar spine bone mineral density after nine months of treatment. This, together with a 15% lower price than Aventis‘ expensive type 1 Gaucher treatment could give the Irish an advantage in the market for the rare disease, that is narrow but lucrative.

Until VPRIV was approved in 40 countries, Aventis subsidiary Genzyme was able to charge $200,000 per year per patient for its treatment that dates back to 1997, but other players are now trying to get a piece of the cake. Pfizer and its development partner Protalix currently got US market authorisation for its plant-cell based enzyme expression therapy Elelyso (taliglucerase alfa) but it was rebuffed at the end of June by the EMA. VPRIV is made in a human cell line using Shire’s gene activation technology.

Type 1 Gaucher disease is caused by a lack of the enzyme β-glucocerebrosidase, which normally breaks down a fatty waste product called glucosylceramide. Without the enzyme, glucosylceramide builds up in the body, typically in the liver, spleen and bone marrow, which produces the symptoms of the disease: anaemia (low red blood cell counts), tiredness, easy bruising and a tendency to bleed, an enlarged spleen and liver, and bone pain and breaks. The latter symptoms are now addressed by Shires enzyme replacement therapy, according to surrogate marker data presented at the European Working Group on Gaucher Disease (EWGGD) meeting in Paris.

http://www.european-biotechnology-news.com/news/news/2012-02/shire-attacks-treatment-monopoly-of-sanofi.html

Clinical TrialsFrance

26.08.2016 Adocia said it would discontinue its diabetic foot ulcer programme after its lead product BioChaperone PDGF disappointed in Phase III. The French company will turn the focus on its earlier-stage products.

M&AUKSweden

24.08.2016 Pharma major Pfizer is putting the cherry on top of its multi-billion-dollar takeover of Medivation with the acquisition of AstraZeneca’s antibiotics for a cool US$1.5bn. With the divestment, AZ aims to further sharpen its focus.

FinancingUK

23.08.2016 Cambridge University-allied investor Cambridge Innovation Capital has raised £75m (€87m) to reinvest in technology and healthcare companies. Among the backers were Woodford Investment and Winton Ventures.

R&DDenmark

19.08.2016 Together with partner Johnson & Johnson, Danish biotech Genmab is now one step closer to FDA approval with its combination treatment for multiple myeloma after its submission of a supplemental Biologics License Application. In July, Genmab was granted a Breakthrough Therapy Designation (BTD) for its blood cancer therapy.

ResearchUKEU

17.08.2016 Philip Hammond, the UK’S chancellor has announced the government will guarantee funding for EU-backed "structural and investment fund" projects whose timelines extend beyond the UK’s departure from the EU, provided the projects are signed prior to this year's Autumn Statement on the UK budget. The decision ensures continued funding for farmers, companies and institutions involved in the EU’s Horizon 2020 project. The move could cost the UK government up to £6bn (€6.9bn).

Stock marketsGermany

15.08.2016 Back in April, the American FDA gave the green light for the colorectal cancer-screening test Epi procolon. Now Berlin-based diagnostics specialist Epigenomics is considering a secondary listing in the US. A draft of the required registration document was confidentially submitted to the US Securities and Exchange Commission (SEC).

LicensingDenmark

11.08.2016 Danish Genmab AS has granted Gilead Sciences license to use its DuoBody technology platform to develop bispecific antibodies for the treatment of HIV. The deal is worth up to €252m.

Clinical developmentHungaryIreland

09.08.2016 Hungarian Gedeon Richter and Irish Allergan are staying on course in the face of dissappointing Phase III results for depression drug cariprazine. The partners will now begin another Phase III study needed for approval.

ImmunotherapySpain

08.08.2016 Araclon Biotech’s Alzheimer’s vaccine ABvac40 is going forward into Phase II after showing a good safety profile in Phase I. The promising trial results were presented at the Alzheimer’s Association International Conference.

ApprovalEU

04.08.2016 After a two-year pilot period, the EMA has published its report on its adaptive pathways approach. The agency plans to “explore the concept further” and will continue to accept proposals.

Quick news provided by GlobeNewswire

View more stock news

Events

All Events

Partner-Events

Current issue

All issues

Product of the week

Products

Stock list

All quotes

TOP

  • NORDIC NANOVECTOR (N)31.90 NOK12.72%
  • VITA 34 (D)4.46 EUR5.69%
  • SAREUM HOLDINGS (UK)0.78 GBP5.41%

FLOP

  • MOLOGEN (D)1.80 EUR-6.74%
  • GW PHARMACEUTICALS (UK)518.00 GBP-5.39%
  • DIAXONHIT (F)0.38 EUR-5.00%

TOP

  • DIAMYD MEDICAL -B- (S)7.20 SEK66.7%
  • KARO BIO (S)41.60 SEK35.1%
  • NORDIC NANOVECTOR (N)31.90 NOK30.7%

FLOP

  • BIONOR PHARMA (N)0.44 NOK-25.4%
  • MOLOGEN (D)1.80 EUR-21.7%
  • WILEX (D)1.50 EUR-13.3%

TOP

  • NICOX (F)10.18 EUR435.8%
  • SAREUM HOLDINGS (UK)0.78 GBP254.5%
  • GENMAB (DK)1103.00 DKK80.8%

FLOP

  • BB BIOTECH (D)45.05 EUR-83.2%
  • EVOCUTIS (UK)0.04 GBP-80.0%
  • CIRCASSIA LIMITED (L)92.75 GBP-71.7%

No liability assumed, Date: 26.08.2016