Immune factor prevents AMD onset
Enlarge image

ResearchIreland

Immune factor prevents AMD onset

10.04.2012 - Controlling the level of the immune factor IL-18 could prevent the development of age-related macular degeneration.

Dublin – Researchers at Trinity College Dublin have discovered that an immune factor secreted by the NLRP3 inflammosome controls the progression of age-related macular degeneration (AMD), one of the most common forms of blindness. When the research team, headed by Sarah Doyle and Matthew Campbell, examined so-called drusen – yellow deposits in the retinas of patients and animals with AMD – they found that they expressed the two immune factors IL-1beta and IL-18 (Nature Medicine, doi:10.1038/nm.2717). Further analyses demonstrated that IL-18 was required for the disease to progress from its dry form to the wet form, where blood vessels underneath the retina begin to grow, leading to central blindness. Thus, activation of the NLRP3 inflammosome which leads to expression of IL-18 seems a promising therapeutic approach to preventing the onset of wet AMD. Dr. Campbell commented, "Traditionally, inflammation in the retina or indeed the eye in general is not beneficial and is a pathological hallmark of many eye diseases, including AMD. However, we have identified that one inflammatory component termed IL-18 acts as a so-called anti-angiogenic factor, preventing the progression of wet AMD." Dr Doyle stressed, "Our results directly suggest that controlling the levels of IL-18 in the retinas of patients with dry AMD could prevent the development of the wet form of disease, which leads us to an exciting new prospect for a novel therapy for AMD."

.

http://www.european-biotechnology-news.com/news/news/2012-02/immune-factor-prevents-amd-onset.html

GenericsEUUKHungaryGermanyItalyGreeceAustriaLuxembourgFranceSpain

26.02.2015 It is the first biosimilar monoclonal antibody in many European markets: Mundipharma and Hospira are launching Celltrion’s Remicade generic.

M&AUK

23.02.2015 British drug developer Heptares has been acquired by Japanese biopharma play Sosei for US$400m (€352m).

bioethanolGermanyUKBelgiumFrance

19.02.2015 The price of oil has been sliding for months, and the European bioethanol market is taking it hard. CropEnergies AG has now stopped production at its British unit Ensus UK.

BusinessFranceGermany

17.02.2015 After Christopher Viehbacher’s unceremonious ousting last year, Sanofi has been on the look out for a new CEO. Now, sources say Bayer’s Olivier Brandicourt is set to fill the position.

BusinessUKSwitzerland

12.02.2015 Glaxosmithkline is intent on bolstering its vaccine portfolio further and has bought all shares of Swiss development partner Glycovaxyn.

InvestmentsUKEU

10.02.2015 Interest in biotechnology is on the rise among British investors. Not just one, but two major financiers are planning investment funds in the field.

IVFUKEU

04.02.2015 In a historic move, the UK is set to become the first country to allow the creation of babies with the genetic material of three people – a mother, a father and a female mitochondrial donor.

Events

All Events

Current issue

All issues

Product of the week

Products

Stock list

All quotes

TOP

  • SARTORIUS128.00 EUR3.85%
  • CO.DON2.29 EUR3.15%
  • WILEX3.03 EUR2.71%

FLOP

  • SANTHERA96.50 CHF-3.40%
  • PAION2.03 EUR-2.87%
  • ADDEX3.16 CHF-2.47%

TOP

  • WILEX3.03 EUR52.3%
  • SARTORIUS128.00 EUR17.9%
  • FORMYCON16.15 EUR16.2%

FLOP

  • ADDEX3.16 CHF-8.1%
  • SANTHERA96.50 CHF-6.3%
  • BIOFRONTERA1.90 EUR-5.9%

TOP

  • SANTHERA96.50 CHF2387.1%
  • WILEX3.03 EUR413.6%
  • FORMYCON16.15 EUR99.9%

FLOP

  • CYTOS0.33 CHF-89.0%
  • MOLOGEN5.65 EUR-53.5%
  • PAION2.03 EUR-53.0%

No liability assumed, Date: 26.02.2015