Immune factor prevents AMD onset
Enlarge image

ResearchIreland

Immune factor prevents AMD onset

10.04.2012 - Controlling the level of the immune factor IL-18 could prevent the development of age-related macular degeneration.

Dublin – Researchers at Trinity College Dublin have discovered that an immune factor secreted by the NLRP3 inflammosome controls the progression of age-related macular degeneration (AMD), one of the most common forms of blindness. When the research team, headed by Sarah Doyle and Matthew Campbell, examined so-called drusen – yellow deposits in the retinas of patients and animals with AMD – they found that they expressed the two immune factors IL-1beta and IL-18 (Nature Medicine, doi:10.1038/nm.2717). Further analyses demonstrated that IL-18 was required for the disease to progress from its dry form to the wet form, where blood vessels underneath the retina begin to grow, leading to central blindness. Thus, activation of the NLRP3 inflammosome which leads to expression of IL-18 seems a promising therapeutic approach to preventing the onset of wet AMD. Dr. Campbell commented, "Traditionally, inflammation in the retina or indeed the eye in general is not beneficial and is a pathological hallmark of many eye diseases, including AMD. However, we have identified that one inflammatory component termed IL-18 acts as a so-called anti-angiogenic factor, preventing the progression of wet AMD." Dr Doyle stressed, "Our results directly suggest that controlling the levels of IL-18 in the retinas of patients with dry AMD could prevent the development of the wet form of disease, which leads us to an exciting new prospect for a novel therapy for AMD."

.

http://www.european-biotechnology-news.com/news/news/2012-02/immune-factor-prevents-amd-onset.html

M&AIreland

19.11.2014 It’s not every day that a company is pushed into the top ten of its sector, but that day has come for Actavis. Christmas came early for the new pharma giant after completing a US$66bn (€53bn) takeover battle for the Botox manufacturer Allergan.

Drug DevelopmentGermany

18.11.2014 Merck KGaA and US rival Pfizer have signed a immuno-oncology alliance worth billions: Merck will share the development and commercialisation of its cancer antibody with its US partner – for €2.3bn.

FinanceFrance

14.11.2014 Cosily coinciding with World Diabetes Day on 14th November, French biopharma Les Laboratories Servier has struck a US$1bn deal with US pharma Intarcia Therapeutics for the exclusive rights to Intarcia’s unprecedented therapy for type 2 diabetes.

AwardsFranceGermanySweden

12.11.2014 Glitz and glamour are not words often used to describe science and mathematics. But once a year, celebrities from the science and showbiz world come together at the Breakthough Prizes, a glitzy television bash that honours scientists for their achievements. French life scientist Emmanuelle Charpentier was among this year’s winners.

ResearchEU

10.11.2014 EFPIA’s specialised group Vaccines Europe and the Innovative Medicines Initiative (IMI) have launched a €280m Call for proposals aimed to address the Ebola crisis.

Trade fairGermanyEU

07.11.2014 3,200 participants from 54 countries attended the 20th issue of BIO-Europe. The overall mood of the European biotech sector was modestly optimistic.

AcquisitionGermanyUKSweden

05.11.2014 German Definiens AG has a new owner: Astrazeneca’s biologics R&D arm Medimmune has taken over all the shares of the imaging specialist for US$150m.

AcquisitionSwedenDenmarkUK

04.11.2014 Galecto Biotech has entered an agreement with Bristol-Myers Squibb for the acquisition of the company and its lead drug, providing the Swedish company with the potential of reaching over US$400m.

FinancingSwedenNorway

31.10.2014 Another biotech is leaving the European market place in favour of a US IPO. Swedish Cortendo is now planning to go public in the US after raising €8.8m in bridge financing.

FinancingUK

29.10.2014 British VC fundraiser Advent Life Sciences has raised €184m with its second fund. The money will help seed and build life sciences companies in the UK, Europe and the US, the company said.

Events

All Events

Partner-Events

Current issue

All issues

Product of the week

Products

Stock list

All quotes

TOP

  • THERAMETRICS0.08 CHF14.29%
  • BIOFRONTERA2.52 EUR2.44%
  • SYNGENTA319.30 CHF2.34%

FLOP

  • SARTORIUS97.00 EUR-3.67%
  • CO.DON2.51 EUR-2.33%
  • EVOLVA1.28 CHF-2.29%

TOP

  • CYTOS0.28 CHF86.7%
  • EPIGENOMICS5.15 EUR50.6%
  • STRATEC BIOMEDICAL48.50 EUR29.3%

FLOP

  • BIOFRONTERA2.52 EUR-13.4%
  • CO.DON2.51 EUR-11.0%
  • ADDEX3.07 CHF-10.8%

TOP

  • SANTHERA91.30 CHF2585.3%
  • CO.DON2.51 EUR139.0%
  • BB BIOTECH181.25 EUR63.4%

FLOP

  • CYTOS0.28 CHF-91.8%
  • 4SC0.94 EUR-46.0%
  • MOLOGEN7.35 EUR-41.4%

No liability assumed, Date: 20.11.2014