04.04.2012 - After signing a broad licensing deal with Amgen Inc. that involves five experimental compounds, AstraZeneca is looking for partnerships with industry peers.
London/Stockholm – Martin Mackay, head of research at the London-headquartered drugmaker, which conducts its R&D in Sweden, said he was also considering smaller acquisitions, product licensing deals and more partnerships with big biotech and big pharma. The deal with Amgen buys rights to jointly develop and sell five of the US biotech major's experimental autoimmune drugs, and follows a similar tie-up in diabetes five years ago with Bristol-Myers Squibb. Amgen and AstraZeneca decided to jointly develop and commercialise five of Amgen's mAbs in the field of inflammation. The deal includes the anti-IL17R mAb brodalumab which will begin phase III testing this year in psoriasis. The monoclonal antibody is also being tested in phase II to treat psoriatic arthritis and asthma. The shared portfolio also includes: AMG 139, an undisclosed mAb in Phase Ib testing for Crohn's disease, AMG 157, a mAb in phase Ib testing for asthma and atopic dermatitis, AMG 181, an undisclosed mAb in Phase Ib testing for ulcerative colitis and Crohn's disease and finally AMG 557, a mAb in phase I for systemic lupus erythematosus (SLE). Amgen receives $50m upfront. The partners and will share costs and profits. The British-Swedish company will fund two thirds of costs until 2014, after which the partners will split costs equally. Amgen and AstraZeneca will share profits equally. AstraZeneca is in the lead for the development and commercialisation of AMG 139, AMG 157 and AMG 181, while its US partner is responsible for brodalumab and AMG 557. Analysts expect that AstraZeneca alone will invest about $250m in 2013 and 2014. However, the company declined to comment those numbers. The drugmaker is suffering from recent product failure and shrinking revenues. Mackay announced the intention to close other similar deals by the end of the year.
05.02.2016 It is not yet clear why a man died during a first-in-man clinical trial in January. A preliminary report found several “major shortcomings” by responsible CRO Biotrial. However, all regulations were complied with.
04.02.2016 After having dodged multiple takeover attempts by Monsanto last year, agrobusiness giant Syngenta has now agreed to be acquired by chemical corporation ChemChina. The Swiss company also announced plans to go public within a few years.
01.02.2016 Altering human DNA with the efficient gene editing method CRISPR/Cas9, especially germline modifications, was long considered a taboo. Now, however, UK scientists have received official approval to tinker with embryo DNA.
27.01.2016 Three UK universities have teamed up with three pharma companies to create the Apollo Therapeutics Fund. With the tech transfer fund, the consortium aims to develop scientific research into medicines.
25.01.2016 Affimed means to put a promising drug combination to the test. With support from MSD, the German biopharma will carry out clinical trials for an immunotherapy combining treatments of both companies.
21.01.2016 Stop squandering antibiotics and make research profitable again: at the World Economic Forum in Swiss Davos, 83 pharmaceutical companies have called for a unified approach towards the threat of antimicrobial resistance.