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AstraZeneca and Isis in Antisense deal
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AstraZeneca and Isis in Antisense deal

04.08.2015 - In a deal worth US$65m upfront, AstraZeneca is again teaming up with long-time partner Isis Pharmaceuticals Inc., this time to discover and develop RNA antisense drugs for cardiovascular, metabolic and renal diseases.

As part of the strategic collaboration, the British pharma major with Swedish roots will pay US-based Isis, a specialist in RNA-targeted technology, US$65m (€59.3m) upfront as well as milestone payments for each programme brought to clinical development and royalties.

The two companies first partnered up in 2012 in order to develop RNA therapeutics for cancer in a deal that netted Isis US$31m (€28.3m) upfront. Now, they are expanding the antisense collaboration to cardiovascular, metabolic and renal disease drug discovery and development – among the key therapeutic areas of AstraZeneca in which the company has broad expertise. “Antisense drugs are short, chemically-modified, single-stranded nucleic acids with the ability to target any gene product. They act inside the cells to influence protein production by targeting RNA. Here, they can be brought to either prevent the production of proteins causing disease or increase production of proteins that are deficient due to disease, or target toxic RNAs that are unable to generate proteins. “Antisense-based therapies are rapidly gaining momentum in the clinic and becoming an important component of our early stage pipeline,” commented Mene Pangalos, Executive Vice President, Innovative Medicines & Early Development at AstraZeneca.


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http://www.european-biotechnology-news.com/news/news/2015-03/astrazeneca-and-isis-in-antisense-deal.html

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No liability assumed, Date: 04.08.2015