Clinical Trial

Synthetic mistletoe protein meets endpoint in stopping malignant melanoma

19.08.2011

Hamburg-based Cytavis Pharma GmbH’s heterologously expressed mistletoe protein Aviscuminum (CY-503) has met the primary endpoint of achieving progression-free survival (PFS) of at least 3 months in 31 patients with inoperable malignant melanoma after failure of prior therapy. The company said the results from the interventional Phase II study also point to efficacy of the twice-weekly, sub­cutaneously administered heterodimeric protein, which targets the CD75 receptor on cancer cells and kills them with a cyto­toxic protein at nanogram doses. One-year survival improved by 45% compared to dacarbazine treatment (30%), with median overall survival of 11 months (Dacarbazine: 6-8 months). The firm, which bought the drug patent from the insolvency mass of Germany’s Viscum AG, is running an efficacy study with more than 200 participants in chemo­therapy-refractory metastatic colorectal carcinoma (NCT 00932724).

Politics / Law

23.03.2012

Brussels/Strasbourg – Health claims are set to be drastically limited in the EU. On Wednesday 21 March the Environment Committee of the European Parliament confirmed a proposal of the European Commission to prohibit 1,600 health...

Politics / Law

15.03.2012

Parma/Stockholm – Foodborne bacteria such as Salmonella and Campylobacter are becoming more and more resistant to antimicrobial drugs, according to a joint report published by the European food watchdog EFSA and the European...

BioFunding

09.03.2012

In mid-February, scientists and entrepreneurs from nine EU countries met at the Center for Genomic Regulation (CRG) in Barcelona to launch the 4DCellFate project. Positioned within the FP7 Programme, the consortium will receive...

BioFunding

09.03.2012

Brussels – The EU’s Innovative Medicines Initiative (IMI) will establish the European Lead Factory, an EU-wide public-private partnership aiming to facilitate drug discovery efforts. The Lead Factory will comprise a...

Editorial

07.03.2012

T    he societal and economic challenges facing Europe and the world are complex and interconnected. The Bioeconomy Strategy and Action Plan “Innovating for Sustainable Growth: a Bioeconomy for Europe”, which was adopted by the...

Tech Review

07.03.2012

Intellectual Property (IP) is without question one of the most vital aspects of any bio­tech venture, a key and undisputed factor for success. However, most bio­tech companies are still incapable of unlocking the value of their...

Clinical Trial

07.03.2012

Schlieren – Swiss Cytos Biotechnology Ltd. has been authorised to restructure a convertible bond by Canton of Zurich authorities. The company does not have enough cash to pay it back. Negotiations with bond holders failed in a...

Clinical Trial

06.03.2012

Munich – German 4SC AG jumped 39% to €2.05/share after oncology drug candidate resminostat met the primary endpoint of at least a 20% progression-free survival rate in a Phase II trial to treat patients with hepatocellular...

Editorial

06.03.2012

The start of 2012 witnessed the tides turning in favour of small and mid-cap names in the European Life Sciences sector. Major global biotechnology indices like the NBI, BTK, and BIOTK are up over 15% year to date. The pace of...

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