ROR1 expression not a unique marker for CLL
Budapest – New results from researchers at the Department of Pathology and Experimental Cancer Research in Budapest suggest that expression of the receptor tyrosine kinase-like orphan receptor 1 (ROR1) on the surface of chronic lymphoid leukaemia (CLL) cells can not be used as a surrogate marker for CCL diagnosis (Hematol Oncol. 2010, July 1). Indeed, the pathologists found ROR1 overexpressed at the cell surface of lymphoma cells with leukaemic blood count in different types of non-Hodgkin lymphomas (NHL) compared to control peripheral mononuclear cells. But ROR1 expression was not limited to CLL cases, suggesting a general role for ROR1 in lymphoma genesis or maintenance.