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Researchers heal prostate cancer with novel cancer immune therapy

20.06.2011

Leeds –UK researchers have cured mice xenografted with human prostate tumours with a new immune therapy approach. Until now, immune therapy approaches have been highly unsuccessful as each tumour has specific proteins and identifying the right antigens has been a huge challenge. However, researchers headed by Alan Melcher from University of Leeds and US researchers from Mayo Clinic in Rochester have solved this problem by expressing a virally expressed epitope library (VEEL) from normal human prostate. In mice, the researchers detected no autoimmunity. Furthermore, tumours that escaped immune selection adopted a new phenotype and could be treated with a second-line therapy. Most importantly, the DNA library which was expressed in the highly immunogenic vesicular stomatitis virus (VSV), made the immune system 'self-select' the cancer antigens to which to respond and did not react against other healthy parts of the body. Also, the process of self-selection was triggered when the vaccine was injected into the bloodstream, an approach to vaccination that is far more practical than injecting directly into tumours. According to the researchers, use of the cDNA library led to presentation of a broad repertoire of undefined tumour-associated antigens, which reduced emergence of treatment-resistant variants and will permit rational, combined-modality approaches in the clinic.

Politics / Law

23.03.2012

Brussels/Strasbourg – Health claims are set to be drastically limited in the EU. On Wednesday 21 March the Environment Committee of the European Parliament confirmed a proposal of the European Commission to prohibit 1,600 health...

Politics / Law

15.03.2012

Parma/Stockholm – Foodborne bacteria such as Salmonella and Campylobacter are becoming more and more resistant to antimicrobial drugs, according to a joint report published by the European food watchdog EFSA and the European...

BioFunding

09.03.2012

In mid-February, scientists and entrepreneurs from nine EU countries met at the Center for Genomic Regulation (CRG) in Barcelona to launch the 4DCellFate project. Positioned within the FP7 Programme, the consortium will receive...

BioFunding

09.03.2012

Brussels – The EU’s Innovative Medicines Initiative (IMI) will establish the European Lead Factory, an EU-wide public-private partnership aiming to facilitate drug discovery efforts. The Lead Factory will comprise a...

Editorial

07.03.2012

T    he societal and economic challenges facing Europe and the world are complex and interconnected. The Bioeconomy Strategy and Action Plan “Innovating for Sustainable Growth: a Bioeconomy for Europe”, which was adopted by the...

Tech Review

07.03.2012

Intellectual Property (IP) is without question one of the most vital aspects of any bio­tech venture, a key and undisputed factor for success. However, most bio­tech companies are still incapable of unlocking the value of their...

Clinical Trial

07.03.2012

Schlieren – Swiss Cytos Biotechnology Ltd. has been authorised to restructure a convertible bond by Canton of Zurich authorities. The company does not have enough cash to pay it back. Negotiations with bond holders failed in a...

Clinical Trial

06.03.2012

Munich – German 4SC AG jumped 39% to €2.05/share after oncology drug candidate resminostat met the primary endpoint of at least a 20% progression-free survival rate in a Phase II trial to treat patients with hepatocellular...

Editorial

06.03.2012

The start of 2012 witnessed the tides turning in favour of small and mid-cap names in the European Life Sciences sector. Major global biotechnology indices like the NBI, BTK, and BIOTK are up over 15% year to date. The pace of...

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No liability assumed, Date: 16.09.2014


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