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Impact of antibiotic resistance is lower than expected

13.10.2011

Bilthoven – The current impact of hospital acquired infections with multi-resistant bugs is lower than suggested by startling news articles. According to a study of Dutch researchers, bloodstream infections caused by multi-resistant S. aureus (MRSA) and third-generation cephalosporin-resistant E. coli contributed an excess of 255,683 and 120,065 extra bed-days respectively. This translated to an estimated extra cost of €62.0 million, according to BURDEN (Burden of resistance and disease in European nations), the first prospective clinical investigation into the societal burden of hospital acquired infections from 31 European countries.
In PLoS Medicine (doi:10.1371/journal.pmed.1001104), Marlieke de Kraker, Peter Davey and Hajo Grundmann from the Dutch Centre for Infectious Disease Control report about excess mortality, excess hospital stay, and hospital expenditure calculated from data of the European Antibiotic Resistance Surveillance System (EARSS). Data from 1293 hospitals in 31 countries revealed that an estimated 5,503 excess deaths were associated with bloodstream infections caused by MRSA and 2,712 excess deaths from bloodstream infections caused by third-generation cephalosporin-resistant E. coli.
By looking at trends in their analyses de Kraker et al. estimate that 97,000 resistant bloodstream infections and 17,000 associated deaths could occur in 2015, with associated increases in hospital stay and costs. They state that 'Forecasts about changes in the coming years are disturbing; despite anticipated gains in the control of MRSA, the persistently increasing number of infections caused by third-generation cephalosporin-resistant Gram-negative pathogens is likely to outweigh this achievement soon.

Politics / Law

23.03.2012

Brussels/Strasbourg – Health claims are set to be drastically limited in the EU. On Wednesday 21 March the Environment Committee of the European Parliament confirmed a proposal of the European Commission to prohibit 1,600 health...

Politics / Law

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Parma/Stockholm – Foodborne bacteria such as Salmonella and Campylobacter are becoming more and more resistant to antimicrobial drugs, according to a joint report published by the European food watchdog EFSA and the European...

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In mid-February, scientists and entrepreneurs from nine EU countries met at the Center for Genomic Regulation (CRG) in Barcelona to launch the 4DCellFate project. Positioned within the FP7 Programme, the consortium will receive...

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Schlieren – Swiss Cytos Biotechnology Ltd. has been authorised to restructure a convertible bond by Canton of Zurich authorities. The company does not have enough cash to pay it back. Negotiations with bond holders failed in a...

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No liability assumed, Date: 23.04.2014

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