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Researchers heal prostate cancer with novel cancer immune therapy

20.06.2011

Leeds –UK researchers have cured mice xenografted with human prostate tumours with a new immune therapy approach. Until now, immune therapy approaches have been highly unsuccessful as each tumour has specific proteins and identifying the right antigens has been a huge challenge. However, researchers headed by Alan Melcher from University of Leeds and US researchers from Mayo Clinic in Rochester have solved this problem by expressing a virally expressed epitope library (VEEL) from normal human prostate. In mice, the researchers detected no autoimmunity. Furthermore, tumours that escaped immune selection adopted a new phenotype and could be treated with a second-line therapy. Most importantly, the DNA library which was expressed in the highly immunogenic vesicular stomatitis virus (VSV), made the immune system 'self-select' the cancer antigens to which to respond and did not react against other healthy parts of the body. Also, the process of self-selection was triggered when the vaccine was injected into the bloodstream, an approach to vaccination that is far more practical than injecting directly into tumours. According to the researchers, use of the cDNA library led to presentation of a broad repertoire of undefined tumour-associated antigens, which reduced emergence of treatment-resistant variants and will permit rational, combined-modality approaches in the clinic.

UKUK

02.04.2012

London - The not-for-profit UK Biobank, the most comprehensive health study in Britain, is now accessible to researchers from industry and academia. The resource, which contains some 1,000 pieces of health and lifestyle...

UKUK

21.03.2012

London – The British Wellcome Trust announced on 20 March that it will launch a £200m business to invest directly in healthcare and life sciences companies. The business, up to now running under its working title Project Sigma,...

UKUK

07.03.2012

Nanopore sequencer Oxford Nanopore Technologies, a UK firm that promises its third-generation technology could theoretically sequence a human genome in 15 minutes, impressed scientists with the first public presentation of its...

UKUK

06.03.2012

GlaxoSmithKline (GSK) is further strengthening its activity in the area of rare diseases. The London-based pharma giant has signed an early-stage deal to develop and commercialise treatments for lysosomal storage disorders...

UKUK

27.02.2012

London/Montreal - Angiochem will collaborate with British pharma trust GlaxoSmithKline (GSK) plc on treatments for lysosomal storage diseases (LSD). London-based GSK will pay $300m, including up to $31.5m in upfront cash and...

UKUK

08.02.2012

London - GlaxoSmithKline re-adjusts its €3.7bn R&D budget. Following a review, three of 38 R&D units will be cut and four new ones installed, the UK drug company said in a statement on 7 Februray. Furthermore, six of the...

UKUK

03.02.2012

London - AstraZeneca tries to shed some weight, anticipating a tough year ahead. 7,300 jobs will be gone soon, the Anglo-Swedish drug company said in a statement. Research and development operations will be cancelled in...

UKUK

16.01.2012

Newhouse – An example of Schumpeter's dictum of creative destruction can be witnessed in Scotland. A former research site of US-pharma company Merck will be reborn as a biotech science park. BioCity Scotland Ltd, a joint venture...

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