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Reovirus-therapy triggers cancer self destruction

21.02.2011

Leeds/Calgary – Oncolytic reoviruses not only kill cancer cells directly but also force them to secrete cytokines that recruit cancer killing cells from the innate and adaptive immune system. According to researchers from Leeds University (UK) and the Canadian biotech firm Oncolytics Biotech, which is conducting several Phase II study with its reovirus-based cancer treatment Reolysin, this opens up the potential of cancer treatment by "bystander" immune-mediated therapy even in the absence of live virus. Published in Molecular Cancer, researchers showed that growth media from reovirus-infected melanoma cells contained pro-inflammatory cytokins such as IL-8 and Interferon beta (INF-beta), which recruited and activated white blood cells, specifically Natural Killer (NK) cells, dendritic cells (DC) and anti melanoma cytotoxic T cells (CTL) which killed off the tumour. The effect was dependent on inactivation of the protein PKR, which protects non-cancer cells from reovirus infection, and the presence of NF-kappaB. The study shows that reovirus therapy can be effective even though reovirus is cleared shortly after infection, through immune system induction of a tumour-specific immune response that initiates apoptosis of tumour cells.

UKUK

02.04.2012

London - The not-for-profit UK Biobank, the most comprehensive health study in Britain, is now accessible to researchers from industry and academia. The resource, which contains some 1,000 pieces of health and lifestyle...

UKUK

21.03.2012

London – The British Wellcome Trust announced on 20 March that it will launch a £200m business to invest directly in healthcare and life sciences companies. The business, up to now running under its working title Project Sigma,...

UKUK

07.03.2012

Nanopore sequencer Oxford Nanopore Technologies, a UK firm that promises its third-generation technology could theoretically sequence a human genome in 15 minutes, impressed scientists with the first public presentation of its...

UKUK

06.03.2012

GlaxoSmithKline (GSK) is further strengthening its activity in the area of rare diseases. The London-based pharma giant has signed an early-stage deal to develop and commercialise treatments for lysosomal storage disorders...

UKUK

27.02.2012

London/Montreal - Angiochem will collaborate with British pharma trust GlaxoSmithKline (GSK) plc on treatments for lysosomal storage diseases (LSD). London-based GSK will pay $300m, including up to $31.5m in upfront cash and...

UKUK

08.02.2012

London - GlaxoSmithKline re-adjusts its €3.7bn R&D budget. Following a review, three of 38 R&D units will be cut and four new ones installed, the UK drug company said in a statement on 7 Februray. Furthermore, six of the...

UKUK

03.02.2012

London - AstraZeneca tries to shed some weight, anticipating a tough year ahead. 7,300 jobs will be gone soon, the Anglo-Swedish drug company said in a statement. Research and development operations will be cancelled in...

UKUK

16.01.2012

Newhouse – An example of Schumpeter's dictum of creative destruction can be witnessed in Scotland. A former research site of US-pharma company Merck will be reborn as a biotech science park. BioCity Scotland Ltd, a joint venture...

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