New target inhibits wound healing
London – Researchers from Queen Mary’s School of Medicine and Dentistry in London have found a new target that seems to inhibit wound healing (JCI, 5. Feb. 2008). According to Dr. Kairbaan Hodivala-Dilke, inhibition of Smad7 may be a useful approach to treating cutaneous wounds. In knockout mice deficient in the regulatory protein alpha-3-beta-1 that showed an impaired reepithelialisation of wounds, the researchers found increased Smad7 activity and decreased TGF-beta mediated signaling. Blocking Smad7 activity in these mice restored reepithelial programme to levels found in normal mice. The results indicate that alpha-3-beta-1 mediates wound healing indirectly through Smad7 inhibition.