New allergy genes
London – Genotyping results from 1,600 patients who suffer from coeliac disease (gluten allergy) point to seven new risk loci for the condition. Six of these harbour genes implicated in the immune response (CCR3, IL12A, IL18RAP, RGS1, SH2B3 and TAGAP). The researchers under Prof. David van Heel from the London School of Medicine and Dentistry were also able to link six genomic regions to both type 1 diabetes and coeliac disease: HLA-DQ, IL2-IL21, CCR3 and SH2B3 (Nature Genetics, 2 March). “So far our findings explain nearly half of the heritability of coeliac disease – now studies with many more samples from individuals with coeliac disease are needed to identify the precise causal genetic variants from each region, and to understand how these influence biological processes” commented van Heel.