UKUK

Consortium finds chronic liver cirrhosis clues

14.03.2011

Cambridge (UK) – British researchers have discovered 12 new genetic markers involved in the development the chronic autoimmune liver disease biliary cirrhosis, which leads to irritation and swelling of the bile ducts and often ends up in transplant surgery for patients (Nature Genetics). The team from the Wellcome Trust Case Control Consortium systematically compared genetic data from 2500 patients and 7500 healthy volunteers and found 22 regions of the genome that differed significantly, 12 or them previously not known. Five of these are involved in the NF-кB pathway, according to study author George Mells. "For clinicians involved in the management of primary biliary cirrhosis, this study is exciting because it provides new and meaningful insight into the biological origins of this condition," said Mells. The results underpin a growing body of evidence that suggests there are many genetic risk factors that are shared between autoimmune diseases. Of the 22 regions identified in this study of primary biliary cirrhosis, 12 have previously been associated with other autoimmune disorders such as type-1 diabetes, multiple sclerosis and psoriasis. Determining how these shared pathways interact with those that, at this moment in time, appear to be unique to primary biliary cirrhosis is likely to lead to therapeutic progress.

UKUK

02.04.2012

London - The not-for-profit UK Biobank, the most comprehensive health study in Britain, is now accessible to researchers from industry and academia. The resource, which contains some 1,000 pieces of health and lifestyle...

UKUK

21.03.2012

London – The British Wellcome Trust announced on 20 March that it will launch a £200m business to invest directly in healthcare and life sciences companies. The business, up to now running under its working title Project Sigma,...

UKUK

07.03.2012

Nanopore sequencer Oxford Nanopore Technologies, a UK firm that promises its third-generation technology could theoretically sequence a human genome in 15 minutes, impressed scientists with the first public presentation of its...

UKUK

06.03.2012

GlaxoSmithKline (GSK) is further strengthening its activity in the area of rare diseases. The London-based pharma giant has signed an early-stage deal to develop and commercialise treatments for lysosomal storage disorders...

UKUK

27.02.2012

London/Montreal - Angiochem will collaborate with British pharma trust GlaxoSmithKline (GSK) plc on treatments for lysosomal storage diseases (LSD). London-based GSK will pay $300m, including up to $31.5m in upfront cash and...

UKUK

08.02.2012

London - GlaxoSmithKline re-adjusts its €3.7bn R&D budget. Following a review, three of 38 R&D units will be cut and four new ones installed, the UK drug company said in a statement on 7 Februray. Furthermore, six of the...

UKUK

03.02.2012

London - AstraZeneca tries to shed some weight, anticipating a tough year ahead. 7,300 jobs will be gone soon, the Anglo-Swedish drug company said in a statement. Research and development operations will be cancelled in...

UKUK

16.01.2012

Newhouse – An example of Schumpeter's dictum of creative destruction can be witnessed in Scotland. A former research site of US-pharma company Merck will be reborn as a biotech science park. BioCity Scotland Ltd, a joint venture...

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http://www.european-biotechnology-news.com/news/messages-archive/archive-uk/article/consortium-finds-chronic-liver-cirrhosis-clues.html

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