SwitzerlandSwitzerland

Diabetes: microRNAs regulate insulin sensitivity

10.06.2011

Zurich – Overexpression of two microRNAs trigger development of insulin resistance, a hallmark of type II diabetes which affects about 20% of the elderly (aged 55-74) in the western world. In Nature, a research team headed by Markus Stoffel from ETH Zurich and Regulus, a joint venture of Alymnan and Isis Therapeutics, reported yesterday that overexpression of the intronic microRNAs miR103 and mi107 made the insulin receptors on fat and liver cells of obese mice insensitive to the peptide hormone signal and raised blood glucose levels. The effect seems to be mediated by Caveolin-1, which regulates insulin signalling through receptor stabilisation. Targeting of antisense drugs – so called antagomirs – specifically against miR103 and mi107 reversed the effect and restored glucose sensitivity and increased glucose uptake both in mice as well as in human cell cultures. The effect was more pronounced in adipose cells than in liver cells because they contain more Caveolin-1. According to Stoffel, a scientific advisor of Regulus, however it is a long way from the current preclinical stage to establishment of an effective treatment. Insulin resistance develops before type 2 diabetes is established. Insensitivity against insulin on fat and muscle cells blocks glucose uptake into the cells and triggers dissimilation of intracellular triglycerides. At the same time it disturbs regulation of blood glucose levels by liver cells that normally regulate glucose homeostasis by the rate of glucose storage and glycogen dissimilation.

SwitzerlandSwitzerland

30.03.2012

Basel/Hinxton (UK) – Two European teams have created huge repositories of cancer genomics data that help predict drug response. Swiss Novartis and the Boston-based Broad Institute have combined data obtained from large-scale...

SwitzerlandSwitzerland

27.03.2012

London/Lausanne – The global private equity firm Celtic Therapeutic L.L.L.P. believes in the power of antibody-drug conjugates (ADCs). It is investing $50m in a new Switzerland-based company called ADC Therapeutics Sarl which...

SwitzerlandSwitzerland

26.03.2012

Basel/Vienna - Following promising results from a Phase III study, Roche has submitted a regulatory application to EMA for subcutaneous Herceptin (trastuzumab) to treat HER2-positive breast cancer. Roche said subcutaneous...

SwitzerlandSwitzerland

09.03.2012

After the US Food & Drug Administration forced Swiss generics giant Sandoz AG to update its production facilities in Quebec, there are now fears that supplies of some medicines could grow tight in Canada. The regulatory authority...

SwitzerlandSwitzerland

08.03.2012

The hepatitis C space has seen a string of large deals in the last weeks that include a US$11bn buyout of Pharmasset by Gilead. Now Novartis is also trying to get in the game with the purchase of a global exclusive licence from...

SwitzerlandSwitzerland

06.03.2012

Allschwil – Swiss Actelion Ltd. has strengthened its commercial offerings by securing rights in certain countries to Auxilium’s biotech drug Xiaflex for treating tissue buildup under the skin. The US pharma is to receive US$10m...

SwitzerlandSwitzerland

06.03.2012

Zug – Life Sciences specialist HBM partners has raised €90m in the first close of its HBM BioCapital II fund, which will invest in revenue-generating companies in the pharmaceuticals, medical device and diagnostics sectors....

SwitzerlandSwitzerland

05.03.2012

Stans – Mondobiotech, a drug discovery company in troubled waters, could soon be under Italian ownership: The Swiss biotech announced it has entered into exclusive negotiations with Milan-based provider of pharmaceutical and...

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