SwitzerlandSwitzerland

A new prostate cancer blood test

08.02.2011

Zurich – Researchers headed by Wilhelm Krek from ETH Zurich have presented a new strategy for biomarker-based diagnosis of prostate cancer. The researchers said their two-step approach is generally suitable for discovery of serum biomarker signatures corresponding to cancer-causing mutations and subsequent verification (Proc. Natl. Acad Sci USA, doi/10.1073/pnas.1013699108. Comparing wild-type and Pten-null mice’s serum proteins by quantitative proteomics, Krek et al. identified 775 N-linked glycoprotein serum biomarkers. Pten is a prostate cancer biomarker and one of the tumour-suppressors most commonly inactivated in human cancers. From this subproteome, they identified relevant proteins leading to PTEN inactivation in humans. By comparison of the relevant biomarkers with serum proteins occurring in 143 patients with prostate cancer or benign prostatic hyperplasia, they identified 39 ortholog human proteins. Bioinformatic prioritisation of the potential signatures led to a 4-protein diagnostic signature that showed 79% specificity and 85% sensitivity in distinguishing patients with prostate cancer and benign prostatic hyperplasia. The researchers say the signature is suitable for staging of prostate cancer in combination with other diagnostic tests and could prevent current PSA-based over-diagnosis of prostate cancer patients.

SwitzerlandSwitzerland

30.03.2012

Basel/Hinxton (UK) – Two European teams have created huge repositories of cancer genomics data that help predict drug response. Swiss Novartis and the Boston-based Broad Institute have combined data obtained from large-scale...

SwitzerlandSwitzerland

27.03.2012

London/Lausanne – The global private equity firm Celtic Therapeutic L.L.L.P. believes in the power of antibody-drug conjugates (ADCs). It is investing $50m in a new Switzerland-based company called ADC Therapeutics Sarl which...

SwitzerlandSwitzerland

26.03.2012

Basel/Vienna - Following promising results from a Phase III study, Roche has submitted a regulatory application to EMA for subcutaneous Herceptin (trastuzumab) to treat HER2-positive breast cancer. Roche said subcutaneous...

SwitzerlandSwitzerland

09.03.2012

After the US Food & Drug Administration forced Swiss generics giant Sandoz AG to update its production facilities in Quebec, there are now fears that supplies of some medicines could grow tight in Canada. The regulatory authority...

SwitzerlandSwitzerland

08.03.2012

The hepatitis C space has seen a string of large deals in the last weeks that include a US$11bn buyout of Pharmasset by Gilead. Now Novartis is also trying to get in the game with the purchase of a global exclusive licence from...

SwitzerlandSwitzerland

06.03.2012

Allschwil – Swiss Actelion Ltd. has strengthened its commercial offerings by securing rights in certain countries to Auxilium’s biotech drug Xiaflex for treating tissue buildup under the skin. The US pharma is to receive US$10m...

SwitzerlandSwitzerland

06.03.2012

Zug – Life Sciences specialist HBM partners has raised €90m in the first close of its HBM BioCapital II fund, which will invest in revenue-generating companies in the pharmaceuticals, medical device and diagnostics sectors....

SwitzerlandSwitzerland

05.03.2012

Stans – Mondobiotech, a drug discovery company in troubled waters, could soon be under Italian ownership: The Swiss biotech announced it has entered into exclusive negotiations with Milan-based provider of pharmaceutical and...

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