SwedenSweden

The (biosynthetic) gift of sight

15.09.2010

Linköping – In the first clinical study of its kind, Swedish researchers have proven that biosynthetic corneas can offer a real alternative to rare human replacement corneas. In a process developed by Per Fagerholm and May Griffith from the University of Linköping, the biosynthetic corneas restored eyesight in 6 out of 10 patients in the 24 month follow-up, and had improved vision in all of the volunteers participating in the Phase I study. “Pre-implantation, the patients could only read the first row of letters on our chart,” said Fagerholm. “After implantation, they could read the second line. And with contact lenses, they could recognize the letters in the third line. That’s good enough to get a driving license in Sweden.” Although made from human collagen, the corneas did not lead to transplant rejection, as donor corneas do. “Normally when human donor corneas are implanted, drugs – including immunosuppressants – are given for 6-12 months to ward off infections,” said Griffith. “Using biosynthetic corneas, we phased out steroids after seven weeks, after the post-operative inflammation had receded.” While visual improvement was less than that of patients who received donor corneas, nerves regenerated in 90% of the patients – much better than with allogenic implants.
Fagerholm believes that his collagen corneas offer an alternative for replacement corneas because they induce regeneration. “With special microscopes, we saw that the patient’s cells enter the collagen matrix,” he explained. “Unlike with donor corneas, the new cornea that grew on our biosynthetic scaffold is therefore completely made from the patient’s own cells.” Lagerholm sees huge potential for his technique. Worldwide, 1.5 million people with corneal damage or disease go blind annually because they can’t find a suitable donor cornea.

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12.03.2012

Gothenburg – Researchers at the Sahlgrenska Academy have discovered a previously unknown mechanism which helps intestinal bacteria to affect the formation of blood vessels. In a study of mice, the team led by Fredrik Bäckhed...

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08.03.2012

Swiss Nestlé S.A. has extended its collaboration agreement with BioGaia AB. The world’s largest nutrition company is paying up to €50.8m for a perpetual licence to use BioGaia’s patented Lacto­bacillus reuteri in infant nutrition...

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08.03.2012

Stockholm – Swedish drug delivery specialist Orexo AB has announced the intention to cut its headcount by 30% in order to reduce the company's burn rate. The personnel reduction by 35 people is expected to lower the costs by a...

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07.03.2012

After a long period of negotiations, Sweden’s Orexo AB and Belgium’s Janssen Pharmaceutica have terminated their joint research programmes. “Unfortunately, we lack the funds to continue on our own to develop the OX-CLI and OX-ESI...

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06.03.2012

Uppsala/Moscow – Vaccine adjuvant specialist Isconova AB is set to begin receiving royalties and product revenues from Russian partner VetBioChem. The veterinary medicine company has launched two new rabies vaccines for dogs and...

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23.02.2012

Stockholm - Probiotics can help prevent diseases, Swedish researchers have found out. The results are in sharp contrast with all health claim judgements involving probiotics published by the EU's food watchdog EFSA up to now. The...

SwedenSweden

16.02.2012

Huddinge – Full stop for one of Sweden's most promising biotech companies. Karo Bio has terminated the trial of its late-stage cholesterol drug eprotirome and won't proceed with its plans to spin off its preclinical operations....

SwedenSweden

19.12.2011

Helsingborg/Exton – Swedish drug developer DuoCort Pharma AB has been purchased by US-based biopharmaceuticals maker ViroPharma Inc. ViroPharma paid around €25m up front, but DuoCort’s former owners could end up receiving €97m...

SwedenSweden

15.12.2011

Stockholm/Cologne – Researchers at the Swedish Karolinska Institute and the University of Cologne have identified a new protein-based defense mechanism against cancer (Struct. & Molec. Biology, doi: 10.1038/10.1038/nsmb.2188)....

SwedenSweden

15.12.2011

Craigavon/Uppsala – Irish Almac Discovery, a member of the Almac Group, will begin cooperating with Uppsala-based Beactica AB to develop new cancer drug candidates. In late November, the companies announced that Beactica’s Sprint...

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