Poison Receptor Identified
Ljubljana - Scientists at the Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Ljubljana, have identified an intracellular membrane receptor for a snake venom secretory phospholipase A (sPLA). The Slovenian scientists detected a 25 kDa protein which binds the neurotoxin with very high affinity in porcine cerebral cortex.
The integral membrane protein R25 is the first sPLA receptor known to date that localizes to intracellular membranes - most likely in mitochondria, which are known to be targets for sPLA neurotoxins in the nerve endings and are potentially implicated in the process of beta-neurotoxicity. The results might be useful in other medical applications, the scientists claimed.