ItalyItaly

MolMed and GSK fight bubble boy

01.08.2011

Milan/London – Italy’s MolMed SpA has signed a deal with UK-based pharmaceutical giant GlaxoSmithKline to develop a production process for a gene therapy against the rare ‘bubble boy disease’. Over the next two years, GSK will pay the Italian biotech up to EUR5.5m to work on the candidate against ADA-SCID (Adenosine Deaminase Deficiency – Severe Combined Immune Deficiency). The life-threatening disease affects approximately 350 children worldwide. ADA-SCID is caused by a mutation in a single gene that prevents the body from producing the ADA enzyme. In the treatment, which GSK acquired from San Raffaele Telethon Institute in October 2010, the faulty gene is repaired in stem cells derived from the patient’s bone marrow. Previous studies suggest the treatment is able to restore long-term immune function and protect children with ADA-SCID against severe infections. The job is very welcome at MolMed. The Milan-based biotech is still hemor­rhaging money. In the first half of 2011, the firm’s EUR1.3m in revenues were dwarfed by its EUR11.8m in operating costs – and outlay won’t drop anytime soon. In late July, MolMed announced the enrolment of the first patient in a randomised Phase II trial of its investigational anticancer drug NGR-hTNF for the treatment of platinum-resistant/refractory ovarian cancer.

ItalyItaly

07.03.2012

Toscana Biomarkers S.r.l has entered the market for biomarkers with its first diagnostic kit. In late January, the company from Siena signed a licence agreement with DIESSE Ricerche S.r.l, based in Genoa. DIESSE will produce and...

ItalyItaly

07.03.2012

Italian researchers have reprogrammed neonatal cardiomyocytes into iPSCs that can re-differentiate toward CMs more efficiently than either cardiac fibroblast-derived iPS cells or even ES cells. (Cell Death Differ.,...

ItalyItaly

09.01.2012

Rome – A cold virus isolated from chimpanzees might work as an vector for human vaccines. Adenoviruses are principally suitable as vectors for vaccines for their ability to induce strong immune responses. But as most humans have...

ItalyItaly

16.12.2011

Milan/Turku – Italian drug developer Newron SpA has had a roller-coaster ride in the last few months. First Merck Serono decided to drop its stake in the company’s Parkinson’s Disease candidate salfinamide, and returned the...

ItalyItaly

15.12.2011

Genoa/Irvine – Researchers from the universities at Genoa and Irvine (US) have patented a new compound that blocks removal of the endo­cannabinoid painkiller anandamide from the synaptic space by a selective transport system....

ItalyItaly

01.10.2011

Parma/Baranzate – Chiesi Farmaceutici Spa has said it will lengthen its long-term collaboration with NiKem Research, which is focused on developing treatments within the respiratory therapeutic area. The two drug developers have...

ItalyItaly

01.10.2011

Milan/Turku – Biotie Therapies ASA’s announcement that it had signed an agreement to acquire Newron Pharma­ceuticals S.p.A. for €45m is both good and bad news for the Italian biotechnology sector. While Italy is losing one of its...

ItalyItaly

19.08.2011

Como – Shares in Gentium SpA lost about a third of their value on Thursday after The Italian biopharmaceutical company withdrew a marketing application for its drug Defibrotide being used against complications related to stem...

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