IrelandIreland

Elan finds biomarker to monitor Alzheimer’s plaques

02.03.2010

Dublin – The Elan Corporation has established a novel biomarker, 11C-PiB PET, that can detect whether Alzheimer drug candidates can reduce pathogenic beta-amyloid plaques in the brains of patients. With the new marker, Elan demonstrated in a phase II study on 28 patients that J&J’s/Janssen Cilag’s anti-beta-amyloid mAB bapineuzumab reduced cortical fibrillar amyloid-ß load in vivo after 78 weeks of treatment (Lancet Neurology) compared with both baseline and placebo. The technology used in the study could “play a major role in Alzheimer’s research and future clinical trial designs,” said Dr. Menghis Bairu, Elan’s chief medical officer. J&J had acquired Elan’s Alzheimer’s Immunotherapy Program (AIP) in 2008, which includes bapineuzumab IV and sub-cutaneous formulations, ACC-001 and backup compounds. Under the terms of the agreement Elan had received a 49.9% equity interest in Janssen Alzheimer Immunotherapy, Johnson & Johnson’s subsidiary that runs the programme.

IrelandIreland

20.03.2012

While on a trip to strengthen economic ties between Ireland and California, Ireland's minister for jobs, enterprise and innovation, Richard Bruton, revealed on 15 March that two Irish government organisations have provided...

IrelandIreland

16.03.2012

Dublin – Irish drugmaker Shire plc has agreed to pay US-$100m in upfront for Ferrokin Biosciences Inc., a San Francisco-based specialist for iron chelation therapies. US-$225m could be added if certain milestones are achieved....

IrelandIreland

07.03.2012

Abbott Laboratories is to spend a85m and expand its pharmaceutical manu­facturing facility in Sligo (Ireland), saying that would help the company to ensure its supply of compounds in bio­pharmaceutical areas like virology and...

IrelandIreland

24.01.2012

Weston/Dublin - The focus for Tysabri, the MS drug jointly developed by Irish Elan and US-Biogen, has become a little more accurate. The US Food and Drug Administration (FDA) stated that the occurrence of antibodies against the...

IrelandIreland

13.12.2011

Dublin/Cambridge – The University of Cambridge and Irish drugmaker Elan Pharmaceutical Inc. have joined forces in the battle against Alzheimer’s Disease. Together, the two will create the Cambridge-Elan Centre for Research...

IrelandIreland

07.12.2011

Uppsala/Craigavon - Irish Almac trusts a Swedish platform to develop new cancer drug candidates. As Uppsala-based Beactica announced on Tuesday, its Sprint-technology will be used to identify fragment hits against a number of...

IrelandIreland

05.12.2011

Dublin /New York – Irish Tibotec Pharmaceutical Ltd and Bristol-Myers Squibb (BMS) have entered into a clinical collaboration for the treatment of chronic hepatitis C infections with a combination of BMS’ NS5A replication complex...

IrelandIreland

01.10.2011

Athlone – Biopharma group Alkermes has established its new Irish corporate base following its merger with Elan Drug Tech­nologies. The a712m (US$960m) deal agreed back in May – which saw Alkermes acquire Elan’s Athlone-based drug...

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http://www.european-biotechnology-news.com/news/messages-archive/archive-ireland/article/elan-finds-biomarker-to-monitor-alzheimers-plaques.html

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