Researchers identify novel psoriasis target
Dresden/Munich/Bethesda – German and US researchers from NIH and the universities Munich and Dresden have developed the first mouse model ever that exactly mimics human key symptoms of psoriasis. The mice developed the same inflamed itchy patches as human skin does after it was exposed to environmental triggers such as sun burn, bacterial or viral infections, and also scrapes or wounds. Using the model, the group headed by Dr. Ronald Wolf showed that over-expression of the S100 gene, which encodes a calcium-binding protein, induced key features of the common immunological skin disorder. It reproduced severe skin inflammation and elevated T cell levels and proinflammatory cytokines due to over activation of the RAGE receptor protein. The researchers conclude that modulation the S100-RAGE relationship might be a suitable new therapeutic target for psoriasis.