Researchers identify major factor for stem cells pluripotency
Berlin – German researchers have found a major determinant of pluripotency in mouse cells. The findings are essential to understand how to regenerate cells for medical purposes and drug screening. In the EMBO Journal, the group headed by Daniel Besser from Berlin-Based Max-Debruck Center for Molecular Medicine, report that knock-out mice for the protein E-Cadherin were unable to become pluripotent and that mice that could not form the common pluripotency factor Oct 4 over-expressed E-Cadherin. In the light of the new results, stem cell researchers now have to rethink their protocols for reprogramming cells to pluripotent cells.