GermanyGermany

New predictive test to improve cancer survival

04.05.2009

Berlin – Survival rates from colorectal cancer (CRC) differ dramatically according to the stage of the tumor at diagnosis, with survival rates of 90% for patients with stage I disease but only 49% for those with stage III cancer. German researchers now have presented clinical validation data for a revolutionary early biomarker, which allows to recognize if subjects with colorectal carcinoma (CRC) are at high risk to develop fatal metastases or not. „Our correct prediction on whether a subject with colon cancer will develop distant metastases over a period of 10 years, was correct for 78 % of subjects with stage I to III CRC, which expressed MACC1 mRNA at a low level“, lead investigator Ulrike Stein (Max-Delbruck-Center, Berlin) told EuroBiotechNews at the BioTOP Agenda meeting in Berlin. Stein, who has patented MACC1 in 2003 and is awaiting approval this year, is in talks with several companies after initial findings were published in Nature Medicine (doi 10.1038/nm.1889). „Our goal is to develop a quantitative PCR test that predicts the risk of cancer recurrence based on expression of the biomarker MACC1. In Berlin, the group invited the industry to participate in the commercialisation of the findings.
Further data show that patients, who expressed low levels of MACC1, showed 5-year survival rates of 80%, but only 15% for subjects with high MACC1 level. Expression of the MACC1 protein induced cell migration by more than 5-fold, invasion and colony formation by factor
Preclincal analyses of the MACC1 protein, which carries motifs characteristic for tyrosine kinases, and CHiP analyses suggest that MACC1 is a transcriptional regulator of MET, the gene encoding the receptor for the hepatocate growth factor (HGF), which is a target for several cancer drug candidates. Whether the biomarker is also an attractive drug target has to be demonstrated in clinical trials.





GermanyGermany

07.03.2012

The first of February marked a milestone for Leverkusen-based Bio­frontera AG in more ways than one. It was the first day that Ameluz, the firm’s first approved product, could be sold in German pharmacies. It was also the date...

GermanyGermany

07.03.2012

Darmstadt – German pharmaceutical and chemical company Merck KGaA has set a downbeat tone for 2012. CEO Karl-Ludwig Kley said the recently launched cost-cutting programme and tough economic conditions will weigh on profits this...

GermanyGermany

05.03.2012

Mainz/Leuna – Two biotech concepts were amongst the winners of the recent third round of the Excellence Cluster initiative, which is funded by the German Ministry for Research. In Mainz the champagne corks popped especially loud...

GermanyGermany

05.03.2012

German Merck KGaA has closed a licencing agreement with US-based Threshold Pharmaceuticals Inc. The cooperation centres around the hypoxia­-activated drug TH-302, which is currently being studied in a global Phase III study....

GermanyGermany

29.02.2012

Munich – Looking back with satisfaction and bent on a prize for good behaviour, German biopharmaceutical company Wilex AG reported yesterday on the fiscal year 2011 and outlined the shores in sight. The 2011 total revenue was...

GermanyGermany

17.02.2012

Brussels – European cartilage researchers intensify their cooperation. The 'gristle network' comprises scientists from Belgium, France, Germany and Luxembourg. Its members plan to meet regularly to exchange views and information...

27.01.2012

Thousand Oaks/Munich - Bling bling for blinatumomab. It is a compliment for the European life sciences scene and sad news at the same time. Amgen Inc., the world's largest biotechnology company, agreed to buy Micromet Inc., an...

GermanyGermany

20.01.2012

Martinsried - SHELTER is responsible for the fact that the stocks of 4SC behaved like a rodeo horse on Thursday. The shares rose in several stages up to 63%, only to settle at a mere 43% rise at the end of the day. SHELTER is a...

GermanyGermany

17.01.2012

Ludwigshafen – BASF Plant Science GmbH, the agrochemistry and biotech arm of the world-largest chemistry company, thinks that it has outstayed its welcome in Europe. Over the next two years, most of the green biotechnology...

GermanyGermany

10.01.2012

Munich - It is the accolade for Micromet. The German company, which is listed on the U.S. stock exchange, announced today that it has entered into a Cooperative Research and Development Agreement (CRADA) with the renowned US...

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