GermanyGermany

Alzheimer’s – clearing the plaques

01.10.2011

Rostock – German researchers say overexpression of one of the 49 transport proteins that shuttle substances over the blood-brain barrier could be the key to treating Alzheimer’s disease. In mice, the group headed by Jens Pahnke from Rostock University has provided the proof-of-concept for their hypothesis that the onset of AD may be linked to a decrease in activity of the ABCC1 transporter (J Clin Invest., doi: 10.1172/JCI57867). In the brains of ABCC1-deficient transgenic mice, the Ab protein that forms the characteristic Alzheimer plaques accumulated 12- to 14-fold within 150 days compared to mice with the functional transporter. “We believe that clearance of Ab from the brain is the true problem with Alzheimer’s disease,” Pahnke said,“thus we looked for a way to accelerate it.” In screening for potential ABCC1 activators, Pahnke et al. found a highly-effective candidate in an FDA-approved drug against vomiting (Tiethylperazin). After one month of administration, it led to a drop of 75% in the Ab found in the brains of the mice, and improved their Alzheimer’s symptoms. Pahnke believes that the concept that the disease is due to deficient Ab transport over the blood-brain barrier is consistent with the fact that such transport requires a lot of energy, which is provided by mitochondria. In the course of ageing, mitochondrial activity is reduced. He now wants to test the hypothesis in clinical trials with pharma partners.

GermanyGermany

07.03.2012

The first of February marked a milestone for Leverkusen-based Bio­frontera AG in more ways than one. It was the first day that Ameluz, the firm’s first approved product, could be sold in German pharmacies. It was also the date...

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07.03.2012

Darmstadt – German pharmaceutical and chemical company Merck KGaA has set a downbeat tone for 2012. CEO Karl-Ludwig Kley said the recently launched cost-cutting programme and tough economic conditions will weigh on profits this...

GermanyGermany

05.03.2012

Mainz/Leuna – Two biotech concepts were amongst the winners of the recent third round of the Excellence Cluster initiative, which is funded by the German Ministry for Research. In Mainz the champagne corks popped especially loud...

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05.03.2012

German Merck KGaA has closed a licencing agreement with US-based Threshold Pharmaceuticals Inc. The cooperation centres around the hypoxia­-activated drug TH-302, which is currently being studied in a global Phase III study....

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29.02.2012

Munich – Looking back with satisfaction and bent on a prize for good behaviour, German biopharmaceutical company Wilex AG reported yesterday on the fiscal year 2011 and outlined the shores in sight. The 2011 total revenue was...

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17.02.2012

Brussels – European cartilage researchers intensify their cooperation. The 'gristle network' comprises scientists from Belgium, France, Germany and Luxembourg. Its members plan to meet regularly to exchange views and information...

27.01.2012

Thousand Oaks/Munich - Bling bling for blinatumomab. It is a compliment for the European life sciences scene and sad news at the same time. Amgen Inc., the world's largest biotechnology company, agreed to buy Micromet Inc., an...

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20.01.2012

Martinsried - SHELTER is responsible for the fact that the stocks of 4SC behaved like a rodeo horse on Thursday. The shares rose in several stages up to 63%, only to settle at a mere 43% rise at the end of the day. SHELTER is a...

GermanyGermany

17.01.2012

Ludwigshafen – BASF Plant Science GmbH, the agrochemistry and biotech arm of the world-largest chemistry company, thinks that it has outstayed its welcome in Europe. Over the next two years, most of the green biotechnology...

GermanyGermany

10.01.2012

Munich - It is the accolade for Micromet. The German company, which is listed on the U.S. stock exchange, announced today that it has entered into a Cooperative Research and Development Agreement (CRADA) with the renowned US...

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