FranceFrance

Nicox glaucoma drug meets endpoints in Phase IIb study

14.03.2012

Sophia Antipolis/ Madison – French NicOx S.A. and the global eye health specialist Bausch & Lomb have announced positive top-line results from their phase 2b dose finding study with BOL-303259-X, a nitric oxide-donating version of Pfizer’s prostaglandin F2-alpha analogue latanoprost, in 400 patients with open-angle glaucoma or ocular hypertension. As shown in two previous Phase II trials conducted during NiCox’s partnership with Pfizer, which ran from 2004-2009, BOL-303259-X (previously NCX 116, PF-3187207) was superior to Pfizer’s lipophilic prostaglandin F2-alpha formulation latanoprost (Xalatan®). In 2 of 4 dose regimes, the NO-donating drug lowered intraocular pressure (IOP) better than Xalatan. On top of that, the responder rate was 68.7% for the most efficacious dose of BOL-303259-X, compared to 47.5% for Xalatan®. The most frequent side effect was reddening of the eyes (hyperemia). The results triggered a US-$10m milestone from Bausch & Lomb to its French partner. The US eye specialist announced it will initiate a global phase 3 development program for the eye drops. The firms believe that NO improves the IOP lowering effect of prostaglandin F2-alpha. In two Phase II trials completed in 2008, the drug was reported to be at least 20% more effective than Xalatan®, according to Pfizer, which re-licensed all development and commercialisation rights to NiCox in August 2009 after having refocused its drug development priorities.

FranceFrance

28.03.2012

Minneapolis/Banzancourt – Bioamber Inc. is one step closer to the environmental summit. The company's goal is to establish sustainable, "green" chemistry on an industrial scale. The French/US enterprise has now scaled up its...

FranceFrance

13.03.2012

Paris/Barcelona – French pharma company Sanofi strengthens its ties with the Spanish research institution CGR (Center for Genomic Regulation) in Barcelona. CGR stated on 12 March that the two partners agreed upon three years of...

FranceFrance

06.03.2012

Lyon – The sale of 1.6 million shares brought in €25.3m for French Adocia SAS during its IPO on the Euronext Paris. The price of €15.88 values the diabetes specialist at €96.1m at the upper end of the bookbuilding range. Late...

FranceFrance

05.03.2012

Pointing to a new study on Syngenta’s GM maize Bt11, France’s Environment Ministry has asked the European Commission to suspend authorisation for the use of the MON810 maize sold by US agri­biotech giant Monsanto as well. The...

FranceFrance

27.02.2012

Cambridge - Genzyme will shut the doors at its Cambridge R&D site by the end of the year, with up to 60 employees expected to lose their jobs. The move is part of an ongoing global restructuring of R&D by Sanofi, who purchased...

FranceFrance

07.02.2012

Lille – Shares of the French diabetes specialist Genfit S.A. almost doubled when the company published results of its Phase II study with the PPAR alpha and delta modulator GFT505. The compound has met the co-primary and...

FranceFrance

06.02.2012

Shares of the French diabetes specialist almost doubled when the companypublished results of its Phase II study with the PPAR alpha and deltamodulator GFT505. The compound has met the co-primary and secondaryendpoints while...

FranceFrance

02.02.2012

Bagneux - DBV Technologies is planning an IPO on Euronext Paris. The French pharmaceutical group specialising in the treatment of allergies was founded in 2002. DBV's proprietary technology Viaskin is used to administer an...

FranceFrance

12.01.2012

Berlin/Paris – Sanofi Pasteur has licensed a yeast strain from German Organobalance to produce vaccines. With the deal, the vaccines division of the French drugmaker will gain exclusive access to a modified strain of...

FranceFrance

05.01.2012

Stockholm/Suresnes - Swedish BioInvent International AB and French Laboratoires Servier are working together on an oncology target. Under the terms of the agreement, Servier will engage BioInvent to screen its proprietary library...

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