Europeans: more disease SNPs
Helsinki – An international research team under Prof. Rasmus Nielsen from Copenhagen University has discovered that Europeans carry significantly more deleterious mutations in their genomes than Africans. The results are based on the first systematic comparision of genetic variation in roughly 10,000 human genes in 35 volunteers. From 39,440 autosomal SNPs identified by PCR-based exon resequencing and evaluated with the Polypen algorithm (which predicts if an SNP might disrupt protein function with 85% confidence), about 50%had a changed amino acid sequence (Nature 451, 994-997). According to the analyses, Europeans have 26% more homozygous damaging SNPs than Africans. On average, every European carries around 1,000 damaging SNPs in the genome.