DenmarkDenmark

LEO Pharma’s PEP005 meets endpoint in Phase III trial

02.02.2010

Ballerup – Danish dermatology specialist LEO Pharma announced yesterday that its topical treatment PEP005 (ingenol mebutate) for actinic keratosis (AK) has met the primary endoint of of complete clearance of body AK lesions in a Phase III clinical trial. AK is a pre-cancerous skin condition that if left untreated, can lead to the development of skin cancer. According to the American Academy of Dermatology, 40 percent of cases of squamous cell carcinoma begin as AK. Approximately 250 patients were enrolled in the study, which evaluated the use of a 0.05% concentration of PEP005 Gel applied daily as monotherapy for two consecutive days to AK lesions on non-head locations. PEP005 Gel demonstrated a favorable safety profile, was well tolerated and had side effects consistent with those seen in Phase II studies, according to the company. LEO Pharma expects to file for regulatory approval of the treatment in the U.S. and Europe in 2011. The news follows the results of a head-to-head study that compared efficacies of the current treatment, standard Metvix, with German company Biofrontera’s photodynamic therapy plus BF-200 ALA (5-aminolevulinic acid in Biofrontera’s proprietary nanoemulsion BF-200). Results reported that BF-200 ALA, on average, erased all lesions in 78% of the patients, whereas Metvixonly reached a complete healing rate of only 64%, and the placebo group 17%. Biofrontera will file for registration this summer.




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DenmarkDenmark

07.03.2012

Bagsvaerd/Bangalore – Danish Novozymes A/S has begun a new collaboration with Indian Sea6 Energy. The companies will jointly develop enzymes to convert seaweed-based carbohydrates to sugar, which can then be fermented to produce...

DenmarkDenmark

06.03.2012

Prague/Turku/Copenhagen – Danish pharmaceutical company H. Lundbeck A/S yesterday unveiled clinical data on its potential blockbuster drug nalmefene at the 2012 European Congress of Psychiatry clinical in Prague. While Lundbeck...

DenmarkDenmark

05.03.2012

Copenhagen – With the in vitro proof of concept for an undisclosed antibody target, Genmab A/S has reached the second milestone in its collaboration with H. Lundbeck A/S. Genmab will now receive a €1m payment. Under the...

DenmarkDenmark

01.02.2012

Copenhagen/Bangalore – Biofuels need reliable sources of biomass. Novozymes now looks to the ocean to secure biomass. The Danish enzyme specialist announced an exploratory research agreement with Sea6 Energy from India. The...

DenmarkDenmark

02.01.2012

Copenhagen – Hellsinn Healthcare has successfully completed a phase Ib trial in Europe with Zealand Pharma’s GLP-2 (glucagone-like peptide 2) peptide antagonist Elsiglutide (ZP1846). The completion of the study, which was...

DenmarkDenmark

23.12.2011

Copenhagen - An alliance of giants will take a thorough look into biofuels for the maritime sector. The leading enzyme producer Novozymes will team up with parts of the Danish shipping industry, including the world’s largest...

DenmarkDenmark

17.12.2011

Copenhagen/Paris – Danish biopharma­ceuticals company Zealand Pharma A/S has received some positive news. Ever since French partner Sanofi Aventis submitted a marketing authorisation application for Lyxumia (lixisenatide) in...

DenmarkDenmark

07.11.2011

Copenhagen/Paris - The cooperation between Danish biopharmaceutical company Zealand Pharma and French drugmaker Sanofi has borne its first fruit. Sanofi has submitted a marketing authorisation application for Lyxumia...

DenmarkDenmark

01.10.2011

Copenhagen/Ingelheim – Danish HTS expert Nuevolution A/S has signed a license agreement with drugmaker Boeh­ringer Ingelheim (BI). The German pharma company will use Nuevolution’s proprietary Chemetics drug discovery technology...

DenmarkDenmark

25.08.2011

Bagsværd - Novo Nordisk is investing around €134m in a new corporate centre in the Copenhagen suburb Bagsværd. The new office premises will concentrate the top management and 1,100 administrative employees which are currently...

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