Gene Controls Drug Response
Vienna - Minute alterations in the genes which encode multidrug resistance proteins (MDR) in the human brain determine the success of anti-epilepsy drugs. This is the outcome of a study with 630 patients to be presented by Austrian researchers at the 6th International Meeting on Epi-leptology in May at Vienna. Some 80% of people showing a bad response to epilepsy drugs showed a homozygotous 3-bp change in comparison to the genes of people with a „normal“ drug response. The researchers go ahead to establish a gene test on their findings for prediction of drug response.