UKUK

How Burkholderia pseudomallei Causes Melioidosis

09.10.2004

Hinxton - British researchers of The Wellcome Trust Sanger Institute have elucidated why the bacterium Burkholderia pseudomallei causes a disease (melioidosis) which symptoms mimic so much other diseases. Julian Parkhill and his team found that the two chromosomes of B. pseudomallei carry highly segregated genes. Whilst one covers most of the genes that are essential for cell growth, general metabolism and the survival of the organism, the other contains a lot of acquired genes that promote adaptation and survival in different environments. The team says 16 genetic islands represen-ting 6% of the genome are behind this variability. The islands may have origin-ally been acquired from viruses, trans-posons, and other genetic jumpers. They encode proteins that make it easy to exchange genetic material and cause human disease. B. pseudomallei variants can quickly and easily shuffle and exchange these traits, which may be the major factor in the bacteria's ability to survive in soil and cause multifaceted disease in humans. The bug's genetic plasticity makes melioidoisis difficult to treat clinically and to prevent with a vaccine, the team says.

UKUK

23.08.2011

London - GlaxoSmithKline has invested about €1.5m to take a 25.4 percent stake in Autifony Therapeutics, a British biotechnology company spun out of GSK to research treatments for tinnitus and hearing loss. Autifony’s other...

UKUK

19.08.2011

Brussels – While worldwide stock exchanges took a beating in late July and early August, European biotech stocks plunged even more. Stocks of majors like Roche, Novartis and GSK lost more than 10% in the first week of the month,...

Austria, UKUK

17.08.2011

London/Pasching –GE Healthcare vamps up its biopharmaceutical capabilities. The U.K. based unit of the U.S. technology giant General Electric, announced that it has reached an agreement to acquire the Austrian PAA Laboratories....

UKUK

16.08.2011

London – The International Multiple Sclerosis Genetics Consortium, led by the Universities of Cambridge and Oxford and funded by the Wellcome Trust, has identified 29 new genetic variations linked to multiple sclerosis (MS). The...

UKUK

16.08.2011

London – A consortium led by British gene medicince company Ark Therapeutics Group plc has received a EUR5.3m grant from the European Commission’s 7th Framework Programme to fund research to combine Ark’s technology covering...

UKUK

09.08.2011

London - Patents on biomarkers are necessary to encourage innovation and investment in the UK DNA diagnostics market. This is the conclusion of a report from the UK Human Genetics Commission. The paper "Intellectual Property and...

UKUK

15.07.2011

London/Rockville - GlaxoSmithKline and its American partner Human Genome Sciences, Inc. announced today that the European Commission has granted marketing authorisation for belimumab (Benlysta) as an add-on therapy in adult...

UKUK

07.07.2011

The British analytics specialist LGC Ltd. will buy its peer, KBioscience, for an undisclosed sum. The acquisition of KBioscience brings LGC expertise in genotyping services, chemistry and complements its genomic services...

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