UKUK

$300m deal to fight a rare disease

27.02.2012

London/Montreal - Angiochem will collaborate with British pharma trust GlaxoSmithKline (GSK) plc on treatments for lysosomal storage diseases (LSD). London-based GSK will pay $300m, including up to $31.5m in upfront cash and research funding. The cooperation comes as a small surprise, as it was only earlier this month when GSK announced, after a major re-adjustment of R&D budgets and structures, that it wanted to stick to its in-house R&D. Angiochem's field of expertise is the creation of therapeutics which can pass the blood-brain barrier (BBB). The collaboration agreement explicitly lists EPiC-enzymes as the means of choice to penetrate the BBB and to restore enzyme function in the central nervous system. LSDs are rare genetic diseases. Currently about 50 different forms are known. However, which LSD is covered by the deal has not been disclosed. If the approach turns out to be successful, the liaison might be expanded to include additional LSD targets. Angiochem would then be eligible to receive royalties on sales of EPiC- enzymes that arise from the collaboration. Jean-Paul Castaigne, president and CEO of Angiochem, emphasises the clinical goal: “Our collaboration with GSK reflects our belief in the need to effectively address neurological symptoms of lysosomal storage diseases." However, it is also anticipated that an effective EPiC-enzyme drugs will appeal to the peripheral symptoms of LSDs, too. Over a year ago, Angiochem teamed up with notorious Geron Corporation from Menlo Park (USA) in a similar deal to work on two oncology product categories (taxanes and telomerase inhibitors) crossing the BBB.

UKUK

19.08.2011

Brussels – While worldwide stock exchanges took a beating in late July and early August, European biotech stocks plunged even more. Stocks of majors like Roche, Novartis and GSK lost more than 10% in the first week of the month,...

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09.08.2011

London - Patents on biomarkers are necessary to encourage innovation and investment in the UK DNA diagnostics market. This is the conclusion of a report from the UK Human Genetics Commission. The paper "Intellectual Property and...

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The British analytics specialist LGC Ltd. will buy its peer, KBioscience, for an undisclosed sum. The acquisition of KBioscience brings LGC expertise in genotyping services, chemistry and complements its genomic services...

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