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The fifteen-minute genome

07.03.2012

Nanopore sequencer Oxford Nanopore Technologies, a UK firm that promises its third-generation technology could theoretically sequence a human genome in 15 minutes, impressed scientists with the first public presentation of its data on 17 February at the “Advances in Genome Biology and Technology” meeting in Marco Island, Florida (US). The firm’s “Strand sequencing” technology identifies bases in real time by measuring electrical conductivity as a DNA strand is fed through a biological nanopore. The Grid­ION system comprises scalable nodes that contain array chips for multi-nano­pore sequencing of single strands, allowing the user to choose a run time between minutes and days. The initial version, which will be available this year, is designed for real-time sequencing by 2,000 nanopores at once to deliver tens of giga­bits of data per 24 hours. Oxford said that an 8,000-nanopore GridION configuration, which the company asserts could perform whole genome sequencing in 15 minutes, will be available in early 2013. Oxford Nanopore said that GridION will be sold at a price-per-base “as competitive as other leading systems at launch.” The company also said that MinION, a miniature version of the platform, will be available this year. Nano­pore sequencing has the potential to achieve read lengths of up to 10,000 bases, ten times more than the best current platforms. Additionally, the technology promises more cost-effectiveness than current sequencing methods which all are dependent on costly fluorescence cameras and labels. A second application dubbed “Exonuclease sequencing”, which includes enzymatic DNA cleavage, has been partnered with US firm Illumina Inc.

UKUK

14.11.2011

London – GlaxoSmithKline goes west. The British pharmaceutical company launched the $50-million GSK Canada Life Sciences Innovation Fund that will invest in “early-stage breakthrough research” in health care life science in...

UKUK

04.10.2011

Heidelberg/Cambridge/London– A team of researchers from GlaxoSmithKline, the biotech company Cellzome and from Universities Cambridge, Ulm and Amsterdam have found a promising treatment for mixed lineage (MLL-fusion) leukaemia...

UKUK

01.10.2011

Amersham – GE Healthcare intends to remain a major force in cancer therapy. Based in London, the health business of the US technology giant announced it will be reserving €730m of its total R&D budget over the next five years for...

UKUK

01.10.2011

Wolverhampton – One of the challenges for manufacturers of probiotic foods is getting large enough numbers of the bacteria into the intestines; most perish under the strongly acidic conditions in the stomach. Scientists from the...

UKUK

01.10.2011

Washington – British Shire plc gained more than 10% in late August on the London Stock Exchange after the US FDA approved Firazyr (icatibant) for acute attacks of hereditary angioedema. The compound was developed by Berlin-based...

UKUK

26.09.2011

London – The first clinical trial using human embryonic stem cells will be carried out at the Moorfields Eye hospital in London. Doctors will inject retinal cells into the eyes of 12 patients with Stargardt‘s macular dystrophy, a...

UKUK

20.09.2011

Amersham – GE Healthcare intends to stay a major force in cancer. The health business of the US-technological company, which is based in London, announced to reserve €730m of its total R&D budget over the next five years for...

UKUK

29.08.2011

Cambridge - A new biotech spin off from the University of Cambridge launched with €6.8m venture capital. Newco Mission Therapeutics Ltd. plans to develop cancer drugs targeting enzymes in ubiquitin pathways that control cellular...

UKUK

23.08.2011

London - GlaxoSmithKline has invested about €1.5m to take a 25.4 percent stake in Autifony Therapeutics, a British biotechnology company spun out of GSK to research treatments for tinnitus and hearing loss. Autifony’s other...

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