UKUK

Consortium finds chronic liver cirrhosis clues

14.03.2011

Cambridge (UK) – British researchers have discovered 12 new genetic markers involved in the development the chronic autoimmune liver disease biliary cirrhosis, which leads to irritation and swelling of the bile ducts and often ends up in transplant surgery for patients (Nature Genetics). The team from the Wellcome Trust Case Control Consortium systematically compared genetic data from 2500 patients and 7500 healthy volunteers and found 22 regions of the genome that differed significantly, 12 or them previously not known. Five of these are involved in the NF-кB pathway, according to study author George Mells. "For clinicians involved in the management of primary biliary cirrhosis, this study is exciting because it provides new and meaningful insight into the biological origins of this condition," said Mells. The results underpin a growing body of evidence that suggests there are many genetic risk factors that are shared between autoimmune diseases. Of the 22 regions identified in this study of primary biliary cirrhosis, 12 have previously been associated with other autoimmune disorders such as type-1 diabetes, multiple sclerosis and psoriasis. Determining how these shared pathways interact with those that, at this moment in time, appear to be unique to primary biliary cirrhosis is likely to lead to therapeutic progress.

UKUK

22.12.2011

London - Nothing is well if the end is not well. For Astra Zeneca the end of 2011 isn't well at all. A new anti-ovarian cancer drug and a planned antidepressant have underperformed in tests. As a result, AstraZeneca will take a...

UKUK

17.12.2011

Surrey – The UK government is investing an additional £80m (€93.5m) to fund continued development of the Institute for Animal Health (IAH) at Pirbright, an institute of the Biotechnology and Biological Sciences Research Council...

UKUK

15.12.2011

Rijeka/London – Allergies like asthma or psoriasis might arise from environmental toxins, suggest researchers from Rijeka University (Croatia) and King’s College (London). In mice, they identified a special population of T cells...

UKUK

13.12.2011

London – Interesting times ahead in the European cancer treatment market. A report states that in the UK alone, diagnosis and treatment costs are likely to increase by 62%, from £9.4 billion in 2010 to £15.3 billion by 2021. The...

UKUK

12.12.2011

York - Tissue Regenix Group plc plans to raise €29m through the sale of 181.8 million shares. The regenerative medical device company is held within the IP Group portfolio and a spin-out company from the University of Leeds. The...

UKUK

11.12.2011

London – Cancer Research UK has begun recruiting patients in the first phase of its Stratified Medicine Programme, which is aimed at finding cancer biomarkers and establishing a genetic testing service in the UK. The charity’s...

UKUK

06.12.2011

London – British Prime Minister David Cameron is trying to come to the rescue of Britain’s embattled biopharmaceutical industry. He has earmarked €210m to support a “biomedical catalyst fund” to back early-stage academic and...

UKUK

06.12.2011

London - David Cameron plans to come to the rescue of Britain's embattled biopharmaceutical industry. The conservative prime minister has earmarked £180m (€210 million) to support a "biomedical catalyst fund" to back ...

UKUK

25.11.2011

Cancer Research UK has started recruiting patients in the first phase of its Stratified Medicine Program, which is seeking to find cancer biomarkers and establish a genetic testing service in the U.K. The charity's multi-million...

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http://www.european-biotechnology-news.com/nc/news/messages-archive/archive-uk/browse/1/article/consortium-finds-chronic-liver-cirrhosis-clues.html

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