UKUK

$300m deal to fight a rare disease

27.02.2012

London/Montreal - Angiochem will collaborate with British pharma trust GlaxoSmithKline (GSK) plc on treatments for lysosomal storage diseases (LSD). London-based GSK will pay $300m, including up to $31.5m in upfront cash and research funding. The cooperation comes as a small surprise, as it was only earlier this month when GSK announced, after a major re-adjustment of R&D budgets and structures, that it wanted to stick to its in-house R&D. Angiochem's field of expertise is the creation of therapeutics which can pass the blood-brain barrier (BBB). The collaboration agreement explicitly lists EPiC-enzymes as the means of choice to penetrate the BBB and to restore enzyme function in the central nervous system. LSDs are rare genetic diseases. Currently about 50 different forms are known. However, which LSD is covered by the deal has not been disclosed. If the approach turns out to be successful, the liaison might be expanded to include additional LSD targets. Angiochem would then be eligible to receive royalties on sales of EPiC- enzymes that arise from the collaboration. Jean-Paul Castaigne, president and CEO of Angiochem, emphasises the clinical goal: “Our collaboration with GSK reflects our belief in the need to effectively address neurological symptoms of lysosomal storage diseases." However, it is also anticipated that an effective EPiC-enzyme drugs will appeal to the peripheral symptoms of LSDs, too. Over a year ago, Angiochem teamed up with notorious Geron Corporation from Menlo Park (USA) in a similar deal to work on two oncology product categories (taxanes and telomerase inhibitors) crossing the BBB.

UKUK

17.12.2011

Surrey – The UK government is investing an additional £80m (€93.5m) to fund continued development of the Institute for Animal Health (IAH) at Pirbright, an institute of the Biotechnology and Biological Sciences Research Council...

UKUK

15.12.2011

Rijeka/London – Allergies like asthma or psoriasis might arise from environmental toxins, suggest researchers from Rijeka University (Croatia) and King’s College (London). In mice, they identified a special population of T cells...

UKUK

13.12.2011

London – Interesting times ahead in the European cancer treatment market. A report states that in the UK alone, diagnosis and treatment costs are likely to increase by 62%, from £9.4 billion in 2010 to £15.3 billion by 2021. The...

UKUK

12.12.2011

York - Tissue Regenix Group plc plans to raise €29m through the sale of 181.8 million shares. The regenerative medical device company is held within the IP Group portfolio and a spin-out company from the University of Leeds. The...

UKUK

11.12.2011

London – Cancer Research UK has begun recruiting patients in the first phase of its Stratified Medicine Programme, which is aimed at finding cancer biomarkers and establishing a genetic testing service in the UK. The charity’s...

UKUK

06.12.2011

London – British Prime Minister David Cameron is trying to come to the rescue of Britain’s embattled biopharmaceutical industry. He has earmarked €210m to support a “biomedical catalyst fund” to back early-stage academic and...

UKUK

06.12.2011

London - David Cameron plans to come to the rescue of Britain's embattled biopharmaceutical industry. The conservative prime minister has earmarked £180m (€210 million) to support a "biomedical catalyst fund" to back ...

UKUK

25.11.2011

Cancer Research UK has started recruiting patients in the first phase of its Stratified Medicine Program, which is seeking to find cancer biomarkers and establish a genetic testing service in the U.K. The charity's multi-million...

UKUK

24.11.2011

London – The European Medicines Agency has recalled all batches of the cancer drugs Busilvex, Velcade and Vidaza manufactured at Boehringer Ingelheim’s Ben Venue Laboratories facility in Bedford, Ohio, from the European market....

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