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The fifteen-minute genome

07.03.2012

Nanopore sequencer Oxford Nanopore Technologies, a UK firm that promises its third-generation technology could theoretically sequence a human genome in 15 minutes, impressed scientists with the first public presentation of its data on 17 February at the “Advances in Genome Biology and Technology” meeting in Marco Island, Florida (US). The firm’s “Strand sequencing” technology identifies bases in real time by measuring electrical conductivity as a DNA strand is fed through a biological nanopore. The Grid­ION system comprises scalable nodes that contain array chips for multi-nano­pore sequencing of single strands, allowing the user to choose a run time between minutes and days. The initial version, which will be available this year, is designed for real-time sequencing by 2,000 nanopores at once to deliver tens of giga­bits of data per 24 hours. Oxford said that an 8,000-nanopore GridION configuration, which the company asserts could perform whole genome sequencing in 15 minutes, will be available in early 2013. Oxford Nanopore said that GridION will be sold at a price-per-base “as competitive as other leading systems at launch.” The company also said that MinION, a miniature version of the platform, will be available this year. Nano­pore sequencing has the potential to achieve read lengths of up to 10,000 bases, ten times more than the best current platforms. Additionally, the technology promises more cost-effectiveness than current sequencing methods which all are dependent on costly fluorescence cameras and labels. A second application dubbed “Exonuclease sequencing”, which includes enzymatic DNA cleavage, has been partnered with US firm Illumina Inc.

UKUK

02.04.2012

London - The not-for-profit UK Biobank, the most comprehensive health study in Britain, is now accessible to researchers from industry and academia. The resource, which contains some 1,000 pieces of health and lifestyle...

UKUK

21.03.2012

London – The British Wellcome Trust announced on 20 March that it will launch a £200m business to invest directly in healthcare and life sciences companies. The business, up to now running under its working title Project Sigma,...

UKUK

06.03.2012

GlaxoSmithKline (GSK) is further strengthening its activity in the area of rare diseases. The London-based pharma giant has signed an early-stage deal to develop and commercialise treatments for lysosomal storage disorders...

UKUK

27.02.2012

London/Montreal - Angiochem will collaborate with British pharma trust GlaxoSmithKline (GSK) plc on treatments for lysosomal storage diseases (LSD). London-based GSK will pay $300m, including up to $31.5m in upfront cash and...

UKUK

08.02.2012

London - GlaxoSmithKline re-adjusts its €3.7bn R&D budget. Following a review, three of 38 R&D units will be cut and four new ones installed, the UK drug company said in a statement on 7 Februray. Furthermore, six of the...

UKUK

03.02.2012

London - AstraZeneca tries to shed some weight, anticipating a tough year ahead. 7,300 jobs will be gone soon, the Anglo-Swedish drug company said in a statement. Research and development operations will be cancelled in...

UKUK

16.01.2012

Newhouse – An example of Schumpeter's dictum of creative destruction can be witnessed in Scotland. A former research site of US-pharma company Merck will be reborn as a biotech science park. BioCity Scotland Ltd, a joint venture...

UKUK

22.12.2011

London - Nothing is well if the end is not well. For Astra Zeneca the end of 2011 isn't well at all. A new anti-ovarian cancer drug and a planned antidepressant have underperformed in tests. As a result, AstraZeneca will take a...

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