SwitzerlandSwitzerland

A new prostate cancer blood test

08.02.2011

Zurich – Researchers headed by Wilhelm Krek from ETH Zurich have presented a new strategy for biomarker-based diagnosis of prostate cancer. The researchers said their two-step approach is generally suitable for discovery of serum biomarker signatures corresponding to cancer-causing mutations and subsequent verification (Proc. Natl. Acad Sci USA, doi/10.1073/pnas.1013699108. Comparing wild-type and Pten-null mice’s serum proteins by quantitative proteomics, Krek et al. identified 775 N-linked glycoprotein serum biomarkers. Pten is a prostate cancer biomarker and one of the tumour-suppressors most commonly inactivated in human cancers. From this subproteome, they identified relevant proteins leading to PTEN inactivation in humans. By comparison of the relevant biomarkers with serum proteins occurring in 143 patients with prostate cancer or benign prostatic hyperplasia, they identified 39 ortholog human proteins. Bioinformatic prioritisation of the potential signatures led to a 4-protein diagnostic signature that showed 79% specificity and 85% sensitivity in distinguishing patients with prostate cancer and benign prostatic hyperplasia. The researchers say the signature is suitable for staging of prostate cancer in combination with other diagnostic tests and could prevent current PSA-based over-diagnosis of prostate cancer patients.

SwitzerlandSwitzerland

22.08.2011

Liestal – Swiss Santhera Pharmaceuticals and researchers from Newcastle University have published the results from a pivotal clinical trial demonstrating that the firm’s synthetic coenzyme Q10 derivative idebenone significantly...

SwitzerlandSwitzerland

18.08.2011

Basel – Swiss pharma and diagnostics major Roche AG has agreed to buy privately-held Heidelberg-based mtm laboratories AG, a specialist for kits detecting pre-stages of cervical cancer, for up to EUR190m. Under the terms of the...

SwitzerlandSwitzerland

16.08.2011

Reinach – Evolva SA has got its hands on up to €30m of fresh capital. The Swiss specialist for synthetic biology announced that it has entered into a Standby Equity Distribution Agreement (SEDA) with YA Global Master SPV Ltd. (YA...

SwitzerlandSwitzerland

15.08.2011

Basel/Waltham - Expecting to be bought by Novartis, U.S. biopharmaceutical firm Proteon Therapeutics Inc. has delivered a new $15.2 million financing. The Swiss pharmaceutical company Novartis obtained exclusive option to acquire...

SwitzerlandSwitzerland

03.08.2011

Zurich - Most of the European men share the DNA of the well known Egyptian pharaoh, Tutankhamun, also called the boy King Tut. According to geneticists at Zurich-based genealogy firm iGENEA, up to 70 percent of British men and...

SwitzerlandSwitzerland

13.07.2011

A big financier of biotech deals could be back on track soon. Novartis is interested in further acquisitions, CEO Joe Jimenez said in an interview published by the "Aargauer Zeitung", a Switzerland- based newspaper.The drugmaker...

SwitzerlandSwitzerland

11.06.2011

Basel – Swiss crop group Syngenta plans to construct a new biotech research facility adjacent to its existing research campus at the Research Triangle Park in North Carolina (US). The US$71m investment is scheduled to begin in...

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