SwitzerlandSwitzerland

Novartis secures share in US6.8bn market for hepatitis C inhibitors

22.02.2012

Basel/Watertown – Swiss Novartis AG has bought a global exclusive licence from Enanta Pharmaceutical Inc. to commercialise drug candidates that help fight off the hepatitis C virus (HCV), which affects 170 million people worldwide. Under the terms of the agreement, Enanta will advance its lead candidate NS5A into clinical development. The firm, which has already gotten IND approval for its HCV replication blocker, will receive an upfront payment of US$34m and milestones that could sum up to US$406m in case of full commercialisation as well as double-digit royalties on global sales. Its picomolar NS5A blocker is a follower to Bristol MyersSquibb’s Phase I first-in-class molecule BMS790052, which seems to address a patient group that is complementary to that of the current standard of care Peg-interferon plus ribavirin. According to experts, NS5A blockers cannot completely replace standard treatment because they are not able to fully eradicate the virus resulting in rapid development of drug resistance. However, they seem to have the potential to broaden the patient group that can benefit from a combination therapy of NS5A blockers plus Peg-interferon and ribavirin. The current standard of care clears most infections with HCV genotype 2 and 3 but succeeds in less than 50% of the patients with genotype 1. According to analyses from Research & Markets the HCV market is to grow annually by about 10% and will reach US$8.6bn in sales in 2016.

SwitzerlandSwitzerland

10.11.2011

Alschwil - Actelion Ltd. gets a badly needed injection of fresh capital. Under the guidance of the two biggest Swiss banks, UBS and Credit Suisse, the Swiss biopharmaceutical company takes up €171 million agreeing to pay a 4,875%...

SwitzerlandSwitzerland

18.10.2011

Basel/San Diego –Swiss drug company Roche has announced it is buying biotech-company Anadys Pharmaceuticals for US$230 million. Under the terms of the merger agreement, Roche will commence an all cash tender offer for all...

Germany, SwitzerlandSwitzerland

12.10.2011

The Swiss technology transfer organisation Unitectra is the winner of the European Biotechnica Award 2011. The specialist for technology transfer received the award from hands of Lower Saxony's Minister for Economy Jörg Bode. The...

SwitzerlandSwitzerland

01.10.2011

Liestal – Swiss Santhera AG has announced strict savings measures. Out of a total of 21 employees, almost every second is now slated to be sacked. The biotech firm is closing its department of preclinical development and scaling...

SwitzerlandSwitzerland

01.10.2011

Schlieren – Swiss biotechnology company Cytos AG has finally devised a plan to help its lead candidate into Phase II, but to achieve it, the cash-strapped company is having to slash its workforce by a whopping 85%. To ensure the...

SwitzerlandSwitzerland

01.10.2011

Geneva – Swiss biotech Addex Pharmaceuticals AG has regained all rights to its metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulator (PAM) programme from Merck&Co, (known as MSD outside the United States and...

SwitzerlandSwitzerland

01.10.2011

Hamburg – When the compound EVT302 failed proof-of-concept testing in the spring of 2009, investors began backing away from Evotec AG shares. Now the selective MAO-B inhibitor is back, and has powered a leap in the company’s...

SwitzerlandSwitzerland

15.09.2011

Zurich – The FDA has posted a manufacturing warning to Lonza following an inspection of the firm's microbial production site for Eisai’s cancer drug Ontak in Hopkinton. However, analysts at Vontobel said that the impact of the...

SwitzerlandSwitzerland

30.08.2011

Schlieren - Swiss biotechnology company Cytos has devised a plan to get its lead candidate into Phase II. To achieve this, the cash strapped company will slash its workforce, as previously announced, by 85%. To ensure the...

SwitzerlandSwitzerland

22.08.2011

Liestal – Swiss Santhera Pharmaceuticals and researchers from Newcastle University have published the results from a pivotal clinical trial demonstrating that the firm’s synthetic coenzyme Q10 derivative idebenone significantly...

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